FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803006587> ?p ?o ?g. }

• W2803006587 endingPage "137" @default.
• W2803006587 startingPage "123" @default.
• W2803006587 abstract "Cognitive function declines substantially with age in both humans and animal models. In humans, this decline is associated with decreases in independence and quality of life. Although the methodology for analysis of cognitive function in human models is relatively well established, similar analyses in animal models have many technical issues (e.g., unintended experimenter bias, motivational issues, stress, and testing during the light phase of the light dark cycle) that limit interpretation of the results. These caveats, and others, potentially bias the interpretation of studies in rodents and prevent the application of current tests of learning and memory as part of an overall healthspan assessment in rodent models of aging. The goal of this study was to establish the methodology to assess cognitive function in aging animals that addresses many of these concerns. Here, we use a food reward-based discrimination procedure with minimal stress in C57Bl/6J male mice at 6, 21, and 27 months of age, followed by a reversal task to assess behavioral flexibility. Importantly, the procedures minimize issues related to between-experimenter confounds and are conducted during both the dark and light phases of the light dark cycle in a home-cage setting. During cognitive testing, we were able to assess multiple measures of spontaneous movement and diurnal activity in young and aged mice including, distance moved, velocity, and acceleration over a 90-h period. Both initial discrimination and reversal learning significantly decreased with age and, similar to rats and humans, not all old mice demonstrated impairments in learning with age. These results permitted classification of animals based on their cognitive status. Analysis of movement parameters indicated decreases in distance moved as well as velocity and acceleration with increasing age. Based on these data, we developed preliminary models indicating, as in humans, a close relationship exists between age-related movement parameters and cognitive ability. Our results provide a reliable method for assessing cognitive performance with minimal stress and simultaneously provide key information on movement and diurnal activity. These methods represent a novel approach to developing non-invasive healthspan measures in rodent models that allow standardization across laboratories." @default.
• W2803006587 created "2018-05-17" @default.
• W2803006587 creator A5012616185 @default.
• W2803006587 creator A5018627313 @default.
• W2803006587 creator A5020830848 @default.
• W2803006587 creator A5021282382 @default.
• W2803006587 creator A5036504629 @default.
• W2803006587 creator A5037987844 @default.
• W2803006587 creator A5043632388 @default.
• W2803006587 creator A5048117873 @default.
• W2803006587 creator A5061020688 @default.
• W2803006587 creator A5062339426 @default.
• W2803006587 creator A5068947959 @default.
• W2803006587 creator A5084924216 @default.
• W2803006587 date "2018-04-01" @default.
• W2803006587 modified "2023-10-18" @default.
• W2803006587 title "Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice" @default.
• W2803006587 cites W1960796618 @default.
• W2803006587 cites W1970836662 @default.
• W2803006587 cites W1975532215 @default.
• W2803006587 cites W1982497009 @default.
• W2803006587 cites W1995047146 @default.
• W2803006587 cites W2008376603 @default.
• W2803006587 cites W2045305761 @default.
• W2803006587 cites W2046635997 @default.
• W2803006587 cites W2057956870 @default.
• W2803006587 cites W2069519394 @default.
• W2803006587 cites W2078425802 @default.
• W2803006587 cites W2078659766 @default.
• W2803006587 cites W2079933139 @default.
• W2803006587 cites W2080086352 @default.
• W2803006587 cites W2085569253 @default.
• W2803006587 cites W2086888830 @default.
• W2803006587 cites W2099742817 @default.
• W2803006587 cites W2099770557 @default.
• W2803006587 cites W2109975763 @default.
• W2803006587 cites W2115515636 @default.
• W2803006587 cites W2117619240 @default.
• W2803006587 cites W2128807350 @default.
• W2803006587 cites W2136493937 @default.
• W2803006587 cites W2138521217 @default.
• W2803006587 cites W2139970306 @default.
• W2803006587 cites W2141890688 @default.
• W2803006587 cites W2145913238 @default.
• W2803006587 cites W2153302582 @default.
• W2803006587 cites W2160643135 @default.
• W2803006587 cites W2164059021 @default.
• W2803006587 cites W2164361361 @default.
• W2803006587 cites W2171776652 @default.
• W2803006587 cites W2210634983 @default.
• W2803006587 cites W2298673178 @default.
• W2803006587 cites W2344471236 @default.
• W2803006587 cites W2403613983 @default.
• W2803006587 cites W2415692047 @default.
• W2803006587 cites W2576174750 @default.
• W2803006587 cites W2604494792 @default.
• W2803006587 cites W2607028609 @default.
• W2803006587 cites W2616343103 @default.
• W2803006587 cites W2729156329 @default.
• W2803006587 cites W2745342799 @default.
• W2803006587 cites W2746304257 @default.
• W2803006587 cites W2770936858 @default.
• W2803006587 cites W2782079306 @default.
• W2803006587 cites W2782629391 @default.
• W2803006587 cites W2791406808 @default.
• W2803006587 cites W2792132707 @default.
• W2803006587 cites W4984562 @default.
• W2803006587 cites W637241509 @default.
• W2803006587 cites W849239701 @default.
• W2803006587 doi "https://doi.org/10.1007/s11357-018-0019-x" @default.
• W2803006587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5964055" @default.
• W2803006587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29687240" @default.
• W2803006587 hasPublicationYear "2018" @default.
• W2803006587 type Work @default.
• W2803006587 sameAs 2803006587 @default.
• W2803006587 citedByCount "27" @default.
• W2803006587 countsByYear W28030065872019 @default.
• W2803006587 countsByYear W28030065872020 @default.
• W2803006587 countsByYear W28030065872021 @default.
• W2803006587 countsByYear W28030065872022 @default.
• W2803006587 countsByYear W28030065872023 @default.
• W2803006587 crossrefType "journal-article" @default.
• W2803006587 hasAuthorship W2803006587A5012616185 @default.
• W2803006587 hasAuthorship W2803006587A5018627313 @default.
• W2803006587 hasAuthorship W2803006587A5020830848 @default.
• W2803006587 hasAuthorship W2803006587A5021282382 @default.
• W2803006587 hasAuthorship W2803006587A5036504629 @default.
• W2803006587 hasAuthorship W2803006587A5037987844 @default.
• W2803006587 hasAuthorship W2803006587A5043632388 @default.
• W2803006587 hasAuthorship W2803006587A5048117873 @default.
• W2803006587 hasAuthorship W2803006587A5061020688 @default.
• W2803006587 hasAuthorship W2803006587A5062339426 @default.
• W2803006587 hasAuthorship W2803006587A5068947959 @default.
• W2803006587 hasAuthorship W2803006587A5084924216 @default.
• W2803006587 hasBestOaLocation W28030065872 @default.
• W2803006587 hasConcept C105795698 @default.
• W2803006587 hasConcept C121446783 @default.
• W2803006587 hasConcept C138496976 @default.

• next