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- W2803017118 abstract "Abstract Parkinson's disease is the most common neurodegenerative movement disorder. It arises as a result of neuronal cell death in specific brain regions, notably the substantia nigra pars compacta, and is characterized by the accumulation of α‐synuclein in these brain regions. Current pharmacological therapies alleviate the motor symptoms of the disease and are particularly effective in the early stages of the disease. Ongoing drug development efforts focus on disease‐modifying strategies that aim to halt or slow disease progression. In this review, we explore a number of emerging disease‐modifying strategies with a focus on direct and indirect targeting of α‐synuclein dysfunction. We summarize newer classes of small molecules and biological agents intended to attenuate protein aggregation or to target enzymes that may increase the degradation of the pathogenic forms of α‐synuclein. Finally, we discuss emerging strategies that are demonstrating the potential for disease modification at the preclinical stage." @default.
- W2803017118 created "2018-05-17" @default.
- W2803017118 creator A5033165479 @default.
- W2803017118 creator A5077133037 @default.
- W2803017118 creator A5091243638 @default.
- W2803017118 date "2018-06-03" @default.
- W2803017118 modified "2023-10-06" @default.
- W2803017118 title "Emerging disease-modifying strategies targeting α-synuclein for the treatment of Parkinson's disease" @default.
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- W2803017118 doi "https://doi.org/10.1111/bph.14345" @default.
- W2803017118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6031880" @default.
- W2803017118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29722028" @default.
- W2803017118 hasPublicationYear "2018" @default.
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