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• W2803019683 endingPage "686" @default.
• W2803019683 startingPage "686" @default.
• W2803019683 abstract "Osteoarthritis (OA) has become one of the most common disabilities among elders, especially in females. Obesity and mechanical injuries caused by OA are attributed to joint loading, cartilage disintegration, and bone loss, as well as inflammation. Pharmacological and non-pharmacological treatments can be used for OA. Fucoidan possesses several bioactivities such as antitumor, antiviral, anticoagulation, anti-obesity, and immunomodulation. This study aims to investigate the effect of fucoidan in surgery-induced OA on rats with diet-induced obesity. OA was induced by an anterior cruciate ligament transection and a partial medial meniscectomy (ACLT + MMx). The male SD rats were fed with a high-fat diet (HFD) for 4 weeks to induce obesity before causing ACLT + MMx to induce OA. The OA rats were administered with intragastric water or fucoidan in three different concentrations (32 mg/kg, 64 mg/kg, and 320 mg/kg) after the surgeries for 40 days with an HFD. We observed that the swelling in the knee joint was alleviated and the hind paw weight distribution was rectified after feeding them with fucoidan and that there was no significant effect on the weight gain and feed intake. Fucoidan administration indicated no significant variation on the high-density lipoprotein (HDL)-Cholesterol level, but it did indicate reduced plasma triglycerides and low-density lipoprotein (LDL)-Cholesterol levels. In addition, the weight-bearing tests showed an improvement in the fucoidan-treated group. Our results suggested that fucoidan may improve meniscal/ligamentous injury and obesity-induced OA." @default.
• W2803019683 created "2018-05-17" @default.
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• W2803019683 creator A5071950861 @default.
• W2803019683 creator A5083678462 @default.
• W2803019683 date "2018-05-28" @default.
• W2803019683 modified "2023-10-11" @default.
• W2803019683 title "Effect of Fucoidan on Anterior Cruciate Ligament Transection and Medial Meniscectomy Induced Osteoarthritis in High-Fat Diet-Induced Obese Rats" @default.
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• W2803019683 doi "https://doi.org/10.3390/nu10060686" @default.
• W2803019683 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6024650" @default.
• W2803019683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29843440" @default.
• W2803019683 hasPublicationYear "2018" @default.
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