Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803036306> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2803036306 endingPage "140.35" @default.
- W2803036306 startingPage "140.35" @default.
- W2803036306 abstract "Abstract The microbiota is known to influence local and systemic immune responses. To test whether the microbiota can modulate the strength of an alloresponse, we used a minor mismatched (H-Y) skin transplant mouse model in both germ-free (GF) and antibiotic-pre-treated (Abx) mice. Abx mice showed a marked reduction in bacterial diversity of their intestinal and skin flora. Skin allograft survival more than doubled in either GF or Abx mice compared to controls and colonization with a complex microbial community from conventional mice was sufficient to restore faster rejection kinetics in GF mice. Mechanistically, CFSE-labeled CD4+ anti-H-Y Marilyn T cells displayed a decrease in proliferation following in vivo adoptive transfer into Abx hosts as well as after in vitro culture with antigen presenting cells from Abx mice. Together, these data indicate decreased priming of allogeneic T cells when the diversity of resident bacterial communities is diminished. This effect is not due to a reduction in bacterial load but rather a loss of taxon-specific host-microbe interactions. This study illustrates the profound systemic effects of the microbial environment in transplant recipients and points to the microbiota as a potential therapeutic target for enhancing graft acceptance." @default.
- W2803036306 created "2018-05-17" @default.
- W2803036306 creator A5014363474 @default.
- W2803036306 creator A5018863416 @default.
- W2803036306 creator A5023053917 @default.
- W2803036306 creator A5023604639 @default.
- W2803036306 creator A5044987508 @default.
- W2803036306 creator A5048837291 @default.
- W2803036306 creator A5056037326 @default.
- W2803036306 creator A5085681006 @default.
- W2803036306 creator A5090706571 @default.
- W2803036306 date "2015-05-01" @default.
- W2803036306 modified "2023-10-16" @default.
- W2803036306 title "The microbiota accelerates skin graft rejection through enhanced T cell priming (TRAN1P.953)" @default.
- W2803036306 doi "https://doi.org/10.4049/jimmunol.194.supp.140.35" @default.
- W2803036306 hasPublicationYear "2015" @default.
- W2803036306 type Work @default.
- W2803036306 sameAs 2803036306 @default.
- W2803036306 citedByCount "0" @default.
- W2803036306 crossrefType "journal-article" @default.
- W2803036306 hasAuthorship W2803036306A5014363474 @default.
- W2803036306 hasAuthorship W2803036306A5018863416 @default.
- W2803036306 hasAuthorship W2803036306A5023053917 @default.
- W2803036306 hasAuthorship W2803036306A5023604639 @default.
- W2803036306 hasAuthorship W2803036306A5044987508 @default.
- W2803036306 hasAuthorship W2803036306A5048837291 @default.
- W2803036306 hasAuthorship W2803036306A5056037326 @default.
- W2803036306 hasAuthorship W2803036306A5085681006 @default.
- W2803036306 hasAuthorship W2803036306A5090706571 @default.
- W2803036306 hasConcept C105795698 @default.
- W2803036306 hasConcept C144027150 @default.
- W2803036306 hasConcept C150903083 @default.
- W2803036306 hasConcept C203014093 @default.
- W2803036306 hasConcept C207001950 @default.
- W2803036306 hasConcept C2776090121 @default.
- W2803036306 hasConcept C2776096895 @default.
- W2803036306 hasConcept C33923547 @default.
- W2803036306 hasConcept C60962613 @default.
- W2803036306 hasConcept C81444415 @default.
- W2803036306 hasConcept C86803240 @default.
- W2803036306 hasConcept C8891405 @default.
- W2803036306 hasConcept C89423630 @default.
- W2803036306 hasConcept C90375314 @default.
- W2803036306 hasConceptScore W2803036306C105795698 @default.
- W2803036306 hasConceptScore W2803036306C144027150 @default.
- W2803036306 hasConceptScore W2803036306C150903083 @default.
- W2803036306 hasConceptScore W2803036306C203014093 @default.
- W2803036306 hasConceptScore W2803036306C207001950 @default.
- W2803036306 hasConceptScore W2803036306C2776090121 @default.
- W2803036306 hasConceptScore W2803036306C2776096895 @default.
- W2803036306 hasConceptScore W2803036306C33923547 @default.
- W2803036306 hasConceptScore W2803036306C60962613 @default.
- W2803036306 hasConceptScore W2803036306C81444415 @default.
- W2803036306 hasConceptScore W2803036306C86803240 @default.
- W2803036306 hasConceptScore W2803036306C8891405 @default.
- W2803036306 hasConceptScore W2803036306C89423630 @default.
- W2803036306 hasConceptScore W2803036306C90375314 @default.
- W2803036306 hasIssue "1_Supplement" @default.
- W2803036306 hasLocation W28030363061 @default.
- W2803036306 hasOpenAccess W2803036306 @default.
- W2803036306 hasPrimaryLocation W28030363061 @default.
- W2803036306 hasRelatedWork W1268706690 @default.
- W2803036306 hasRelatedWork W1488028176 @default.
- W2803036306 hasRelatedWork W1930328534 @default.
- W2803036306 hasRelatedWork W1968047100 @default.
- W2803036306 hasRelatedWork W1988241479 @default.
- W2803036306 hasRelatedWork W1994657650 @default.
- W2803036306 hasRelatedWork W2005953772 @default.
- W2803036306 hasRelatedWork W2314327359 @default.
- W2803036306 hasRelatedWork W2410272951 @default.
- W2803036306 hasRelatedWork W2803036306 @default.
- W2803036306 hasVolume "194" @default.
- W2803036306 isParatext "false" @default.
- W2803036306 isRetracted "false" @default.
- W2803036306 magId "2803036306" @default.
- W2803036306 workType "article" @default.