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- W2803057438 abstract "Glial cell types were classified less than 100 years ago by del Rio-Hortega. For instance, he correctly surmised that microglia in pathologic central nervous system (CNS) were voracious monsters that helped clean the tissue. Although these historical predictions were remarkably accurate, innovative technologies have revealed novel molecular, cellular, and dynamic physiologic aspects of CNS glia. In this review, we integrate recent findings regarding the roles of glia and glial interactions in healthy and injured spinal cord. The three major glial cell types are considered in healthy CNS and after spinal cord injury (SCI). Astrocytes, which in the healthy CNS regulate neurotransmitter and neurovascular dynamics, respond to SCI by becoming reactive and forming a glial scar that limits pathology and plasticity. Microglia, which in the healthy CNS scan for infection/damage, respond to SCI by promoting axon growth and remyelination-but also with hyperactivation and cytotoxic effects. Oligodendrocytes and their precursors, which in healthy tissue speed axon conduction and support axonal function, respond to SCI by differentiating and producing myelin, but are susceptible to death. Thus, post-SCI responses of each glial cell can simultaneously stimulate and stifle repair. Interestingly, potential therapies could also target interactions between these cells. Astrocyte-microglia cross-talk creates a feed-forward loop, so shifting the response of either cell could amplify repair. Astrocytes, microglia, and oligodendrocytes/precursors also influence post-SCI cell survival, differentiation, and remyelination, as well as axon sparing. Therefore, optimizing post-SCI responses of glial cells-and interactions between these CNS cells-could benefit neuroprotection, axon plasticity, and functional recovery." @default.
- W2803057438 created "2018-05-17" @default.
- W2803057438 creator A5051353828 @default.
- W2803057438 creator A5075773354 @default.
- W2803057438 date "2018-05-04" @default.
- W2803057438 modified "2023-10-18" @default.
- W2803057438 title "Glial Cells Shape Pathology and Repair After Spinal Cord Injury" @default.
- W2803057438 cites W1137281815 @default.
- W2803057438 cites W1485498049 @default.
- W2803057438 cites W1509596990 @default.
- W2803057438 cites W1522823711 @default.
- W2803057438 cites W1523799993 @default.
- W2803057438 cites W1545421865 @default.
- W2803057438 cites W1552543129 @default.
- W2803057438 cites W1568207206 @default.
- W2803057438 cites W1594747697 @default.
- W2803057438 cites W1595293335 @default.
- W2803057438 cites W1595606162 @default.
- W2803057438 cites W1632883247 @default.
- W2803057438 cites W1635850624 @default.
- W2803057438 cites W1676877312 @default.
- W2803057438 cites W1689660630 @default.
- W2803057438 cites W1723871640 @default.
- W2803057438 cites W1802854491 @default.
- W2803057438 cites W1805879606 @default.
- W2803057438 cites W1822650859 @default.
- W2803057438 cites W1881056933 @default.
- W2803057438 cites W1889485241 @default.
- W2803057438 cites W1901712533 @default.
- W2803057438 cites W1907724378 @default.
- W2803057438 cites W1908112684 @default.
- W2803057438 cites W1921871464 @default.
- W2803057438 cites W1928938384 @default.
- W2803057438 cites W1948491557 @default.
- W2803057438 cites W1949462153 @default.
- W2803057438 cites W1963558935 @default.
- W2803057438 cites W1963683677 @default.
- W2803057438 cites W1965334747 @default.
- W2803057438 cites W1966125392 @default.
- W2803057438 cites W1966708171 @default.
- W2803057438 cites W1967017576 @default.
- W2803057438 cites W1967109943 @default.
- W2803057438 cites W1969305530 @default.
- W2803057438 cites W1969619562 @default.
- W2803057438 cites W1972553563 @default.
- W2803057438 cites W1973619847 @default.
- W2803057438 cites W1973848776 @default.
- W2803057438 cites W1975212239 @default.
- W2803057438 cites W1976152949 @default.
- W2803057438 cites W1976536982 @default.
- W2803057438 cites W1977213877 @default.
- W2803057438 cites W1979038308 @default.
- W2803057438 cites W1980162719 @default.
- W2803057438 cites W1980789245 @default.
- W2803057438 cites W1981030744 @default.
- W2803057438 cites W1981265720 @default.
- W2803057438 cites W1981621010 @default.
- W2803057438 cites W1982598770 @default.
- W2803057438 cites W1983283455 @default.
- W2803057438 cites W1985297297 @default.
- W2803057438 cites W1987030523 @default.
- W2803057438 cites W1989158501 @default.
- W2803057438 cites W1990815396 @default.
- W2803057438 cites W1990964778 @default.
- W2803057438 cites W1991466583 @default.
- W2803057438 cites W1994257911 @default.
- W2803057438 cites W1994581225 @default.
- W2803057438 cites W1994874065 @default.
- W2803057438 cites W1997721049 @default.
- W2803057438 cites W1999495459 @default.
- W2803057438 cites W2000485285 @default.
- W2803057438 cites W2002774469 @default.
- W2803057438 cites W2002869490 @default.
- W2803057438 cites W2002943068 @default.
- W2803057438 cites W2003133530 @default.
- W2803057438 cites W2003981301 @default.
- W2803057438 cites W2005378461 @default.
- W2803057438 cites W2005705586 @default.
- W2803057438 cites W2006184315 @default.
- W2803057438 cites W2006593236 @default.
- W2803057438 cites W2006960578 @default.
- W2803057438 cites W2007067483 @default.
- W2803057438 cites W2008615519 @default.
- W2803057438 cites W2009204676 @default.
- W2803057438 cites W2010882645 @default.
- W2803057438 cites W2011322035 @default.
- W2803057438 cites W2011353038 @default.
- W2803057438 cites W2011937563 @default.
- W2803057438 cites W2011943543 @default.
- W2803057438 cites W2012437957 @default.
- W2803057438 cites W2012442508 @default.
- W2803057438 cites W2012928251 @default.
- W2803057438 cites W2013997823 @default.
- W2803057438 cites W2014958031 @default.
- W2803057438 cites W2015412022 @default.
- W2803057438 cites W2017025515 @default.
- W2803057438 cites W2017847893 @default.
- W2803057438 cites W2019702139 @default.