Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803071366> ?p ?o ?g. }
- W2803071366 endingPage "252" @default.
- W2803071366 startingPage "252" @default.
- W2803071366 abstract "Monozygotic (MZ) twins are typically indistinguishable via forensic DNA profiling. Recently, we demonstrated that epigenetic differentiation of MZ twins is feasible; however, proportions of twin differentially methylated CpG sites (tDMSs) identified in reference-type blood DNA were not replicated in trace-type blood DNA. Here we investigated buccal swabs as typical forensic reference material, and saliva and cigarette butts as commonly encountered forensic trace materials. As an analog to a forensic case, we analyzed one MZ twin pair. Epigenome-wide microarray analysis in reference-type buccal DNA revealed 25 candidate tDMSs with >0.5 twin-to-twin differences. MethyLight quantitative PCR (qPCR) of 22 selected tDMSs in trace-type DNA revealed in saliva DNA that six tDMSs (27.3%) had >0.1 twin-to-twin differences, seven (31.8%) had smaller (<0.1) but robustly detected differences, whereas for nine (40.9%) the differences were in the opposite direction relative to the microarray data; for cigarette butt DNA, results were 50%, 22.7%, and 27.3%, respectively. The discrepancies between reference-type and trace-type DNA outcomes can be explained by cell composition differences, method-to-method variation, and other technical reasons including bisulfite conversion inefficiency. Our study highlights the importance of the DNA source and that careful characterization of biological and technical effects is needed before epigenetic MZ twin differentiation is applicable in forensic casework." @default.
- W2803071366 created "2018-05-17" @default.
- W2803071366 creator A5016280245 @default.
- W2803071366 creator A5018467489 @default.
- W2803071366 creator A5045174307 @default.
- W2803071366 creator A5046702819 @default.
- W2803071366 creator A5054937522 @default.
- W2803071366 creator A5076106859 @default.
- W2803071366 date "2018-05-14" @default.
- W2803071366 modified "2023-09-26" @default.
- W2803071366 title "Investigating the Epigenetic Discrimination of Identical Twins Using Buccal Swabs, Saliva, and Cigarette Butts in the Forensic Setting" @default.
- W2803071366 cites W1784215938 @default.
- W2803071366 cites W1970018638 @default.
- W2803071366 cites W1972431664 @default.
- W2803071366 cites W1977286905 @default.
- W2803071366 cites W1991003437 @default.
- W2803071366 cites W1993542395 @default.
- W2803071366 cites W1999377691 @default.
- W2803071366 cites W2001705484 @default.
- W2803071366 cites W2003398735 @default.
- W2803071366 cites W2021035703 @default.
- W2803071366 cites W2021480557 @default.
- W2803071366 cites W2022152889 @default.
- W2803071366 cites W2024560618 @default.
- W2803071366 cites W2025936795 @default.
- W2803071366 cites W2031035920 @default.
- W2803071366 cites W2031724786 @default.
- W2803071366 cites W2031857387 @default.
- W2803071366 cites W2050112556 @default.
- W2803071366 cites W2051711587 @default.
- W2803071366 cites W2063787315 @default.
- W2803071366 cites W2068853666 @default.
- W2803071366 cites W2084336300 @default.
- W2803071366 cites W2088173470 @default.
- W2803071366 cites W2097743364 @default.
- W2803071366 cites W2101870168 @default.
- W2803071366 cites W2103990329 @default.
- W2803071366 cites W2118094114 @default.
- W2803071366 cites W2127192982 @default.
- W2803071366 cites W2127829299 @default.
- W2803071366 cites W2129915465 @default.
- W2803071366 cites W2134555277 @default.
- W2803071366 cites W2137815533 @default.
- W2803071366 cites W2142817649 @default.
- W2803071366 cites W2144322571 @default.
- W2803071366 cites W2147571480 @default.
- W2803071366 cites W2153250619 @default.
- W2803071366 cites W2158384762 @default.
- W2803071366 cites W2162290916 @default.
- W2803071366 cites W2169556367 @default.
- W2803071366 cites W2170634666 @default.
- W2803071366 cites W2180887073 @default.
- W2803071366 cites W2274593450 @default.
- W2803071366 cites W2329888282 @default.
- W2803071366 cites W2334107927 @default.
- W2803071366 cites W2340182364 @default.
- W2803071366 cites W2422261048 @default.
- W2803071366 cites W2427374097 @default.
- W2803071366 cites W2469748284 @default.
- W2803071366 cites W2514263954 @default.
- W2803071366 cites W2592216350 @default.
- W2803071366 cites W2625290825 @default.
- W2803071366 cites W2748135787 @default.
- W2803071366 cites W290456283 @default.
- W2803071366 doi "https://doi.org/10.3390/genes9050252" @default.
- W2803071366 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5977192" @default.
- W2803071366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29758014" @default.
- W2803071366 hasPublicationYear "2018" @default.
- W2803071366 type Work @default.
- W2803071366 sameAs 2803071366 @default.
- W2803071366 citedByCount "15" @default.
- W2803071366 countsByYear W28030713662018 @default.
- W2803071366 countsByYear W28030713662019 @default.
- W2803071366 countsByYear W28030713662020 @default.
- W2803071366 countsByYear W28030713662021 @default.
- W2803071366 countsByYear W28030713662022 @default.
- W2803071366 countsByYear W28030713662023 @default.
- W2803071366 crossrefType "journal-article" @default.
- W2803071366 hasAuthorship W2803071366A5016280245 @default.
- W2803071366 hasAuthorship W2803071366A5018467489 @default.
- W2803071366 hasAuthorship W2803071366A5045174307 @default.
- W2803071366 hasAuthorship W2803071366A5046702819 @default.
- W2803071366 hasAuthorship W2803071366A5054937522 @default.
- W2803071366 hasAuthorship W2803071366A5076106859 @default.
- W2803071366 hasBestOaLocation W28030713661 @default.
- W2803071366 hasConcept C104317684 @default.
- W2803071366 hasConcept C150194340 @default.
- W2803071366 hasConcept C161890455 @default.
- W2803071366 hasConcept C167871757 @default.
- W2803071366 hasConcept C169594400 @default.
- W2803071366 hasConcept C190727270 @default.
- W2803071366 hasConcept C41091548 @default.
- W2803071366 hasConcept C504460877 @default.
- W2803071366 hasConcept C54355233 @default.
- W2803071366 hasConcept C552990157 @default.
- W2803071366 hasConcept C55493867 @default.
- W2803071366 hasConcept C70721500 @default.
- W2803071366 hasConcept C79386861 @default.