FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803073527> ?p ?o ?g. }

• W2803073527 endingPage "234" @default.
• W2803073527 startingPage "225" @default.
• W2803073527 abstract "Inspired by the natural extracellular matrix, the organic-inorganic composite nanofibers are promising scaffolds for bone tissue engineering. Chitosan-based nanofibers are widely used as bone tissue engineering scaffolds with good biocompatibility but pungent solvents are frequently used for its processing. Carboxymethyl chitosan (CMCS), a water-soluble derivative of chitosan, has better biodegradability and bioactivity which allows CMCS to chelate Ca2+ and induce the deposition of apatite. Moreover, with water as solvent, CMCS nanofibers avoid the acidic salt removal comparing to electrospun-chitosan. In this study, we successfully prepared uniform CMCS nanofibers with the aid of polyethylene oxide (PEO) and obtained the optimized conditions with a voltage of 25 kV and PEO of molecular weight 1000 kDa. We further prepared hydroxyapatite (HA) coated electrospun CMCS nanofibers by biomimetic mineralization using 5 times simulated body fluid. The promotion of osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) in vitro was evaluated on the nanofibers scaffolds. Cell experiments revealed that CMCS-HA composite nanofibers increased the ALP activity. The gene expression level of Runx2 and ALP were about 1.6 and 4.3 folds at the 7 days, and 5.1 and 10 folds at the 14 days on CMCS-HA nanofibrous membranes than that on CMCS alone samples. The level of OCN increased by 24 and 1.5 times on the CMCS-HA scaffolds than CMCS scaffolds at the 14 and 21 days. In vivo new bone formation by nanofiber scaffolds was investigated in a critical-size rat calvarial bone defect model. Micro-CT results showed that the whole defect was covered by new bone after CMCS-HA filling the defect for 12 weeks. The results of H&E staining and Masson’s trichrome staining on histological sections further confirmed that composite nanofibers promoted new bone formation and maturation." @default.
• W2803073527 created "2018-05-17" @default.
• W2803073527 creator A5016587077 @default.
• W2803073527 creator A5024348367 @default.
• W2803073527 creator A5063629567 @default.
• W2803073527 creator A5065852263 @default.
• W2803073527 creator A5084221383 @default.
• W2803073527 date "2018-09-01" @default.
• W2803073527 modified "2023-10-18" @default.
• W2803073527 title "Biomimetic mineralization of carboxymethyl chitosan nanofibers with improved osteogenic activity in vitro and in vivo" @default.
• W2803073527 cites W1965518820 @default.
• W2803073527 cites W1965571950 @default.
• W2803073527 cites W1968020993 @default.
• W2803073527 cites W1969902985 @default.
• W2803073527 cites W1978460527 @default.
• W2803073527 cites W1980326094 @default.
• W2803073527 cites W1982635857 @default.
• W2803073527 cites W1985370231 @default.
• W2803073527 cites W1988649732 @default.
• W2803073527 cites W1995276955 @default.
• W2803073527 cites W1999409223 @default.
• W2803073527 cites W2005052201 @default.
• W2803073527 cites W2029259783 @default.
• W2803073527 cites W2034388383 @default.
• W2803073527 cites W2056104115 @default.
• W2803073527 cites W2057046337 @default.
• W2803073527 cites W2064030241 @default.
• W2803073527 cites W2074683360 @default.
• W2803073527 cites W2087966138 @default.
• W2803073527 cites W2090502184 @default.
• W2803073527 cites W2092281736 @default.
• W2803073527 cites W2119942076 @default.
• W2803073527 cites W2139349063 @default.
• W2803073527 cites W2160035134 @default.
• W2803073527 cites W226515561 @default.
• W2803073527 cites W2274315024 @default.
• W2803073527 cites W2288364049 @default.
• W2803073527 cites W2316401659 @default.
• W2803073527 cites W2317972479 @default.
• W2803073527 cites W2325005906 @default.
• W2803073527 cites W2400608037 @default.
• W2803073527 cites W2516169683 @default.
• W2803073527 cites W2558338587 @default.
• W2803073527 cites W2730052808 @default.
• W2803073527 doi "https://doi.org/10.1016/j.carbpol.2018.04.090" @default.
• W2803073527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29804972" @default.
• W2803073527 hasPublicationYear "2018" @default.
• W2803073527 type Work @default.
• W2803073527 sameAs 2803073527 @default.
• W2803073527 citedByCount "82" @default.
• W2803073527 countsByYear W28030735272018 @default.
• W2803073527 countsByYear W28030735272019 @default.
• W2803073527 countsByYear W28030735272020 @default.
• W2803073527 countsByYear W28030735272021 @default.
• W2803073527 countsByYear W28030735272022 @default.
• W2803073527 countsByYear W28030735272023 @default.
• W2803073527 crossrefType "journal-article" @default.
• W2803073527 hasAuthorship W2803073527A5016587077 @default.
• W2803073527 hasAuthorship W2803073527A5024348367 @default.
• W2803073527 hasAuthorship W2803073527A5063629567 @default.
• W2803073527 hasAuthorship W2803073527A5065852263 @default.
• W2803073527 hasAuthorship W2803073527A5084221383 @default.
• W2803073527 hasConcept C127413603 @default.
• W2803073527 hasConcept C136229726 @default.
• W2803073527 hasConcept C150903083 @default.
• W2803073527 hasConcept C171250308 @default.
• W2803073527 hasConcept C178790620 @default.
• W2803073527 hasConcept C185592680 @default.
• W2803073527 hasConcept C192562407 @default.
• W2803073527 hasConcept C207001950 @default.
• W2803073527 hasConcept C2777230088 @default.
• W2803073527 hasConcept C2779732960 @default.
• W2803073527 hasConcept C42360764 @default.
• W2803073527 hasConcept C49892992 @default.
• W2803073527 hasConcept C55493867 @default.
• W2803073527 hasConcept C71924100 @default.
• W2803073527 hasConcept C86803240 @default.
• W2803073527 hasConcept C91129048 @default.
• W2803073527 hasConceptScore W2803073527C127413603 @default.
• W2803073527 hasConceptScore W2803073527C136229726 @default.
• W2803073527 hasConceptScore W2803073527C150903083 @default.
• W2803073527 hasConceptScore W2803073527C171250308 @default.
• W2803073527 hasConceptScore W2803073527C178790620 @default.
• W2803073527 hasConceptScore W2803073527C185592680 @default.
• W2803073527 hasConceptScore W2803073527C192562407 @default.
• W2803073527 hasConceptScore W2803073527C207001950 @default.
• W2803073527 hasConceptScore W2803073527C2777230088 @default.
• W2803073527 hasConceptScore W2803073527C2779732960 @default.
• W2803073527 hasConceptScore W2803073527C42360764 @default.
• W2803073527 hasConceptScore W2803073527C49892992 @default.
• W2803073527 hasConceptScore W2803073527C55493867 @default.
• W2803073527 hasConceptScore W2803073527C71924100 @default.
• W2803073527 hasConceptScore W2803073527C86803240 @default.
• W2803073527 hasConceptScore W2803073527C91129048 @default.
• W2803073527 hasFunder F4320321001 @default.
• W2803073527 hasLocation W28030735271 @default.
• W2803073527 hasLocation W28030735272 @default.
• W2803073527 hasOpenAccess W2803073527 @default.

• next