FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803080977> ?p ?o ?g. }

• W2803080977 abstract "Background Schizophrenia is currently considered a neurodevelopmental disorder of connectivity. Still few studies have investigated how brain networks develop in children and adolescents who are at risk for developing psychosis. 22q11.2 Deletion Syndrome (22q11DS) offers a unique opportunity to investigate the pathogenesis of schizophrenia from a neurodevelopmental perspective. Structural covariance (SC) is a powerful approach to explore morphometric relations between brain regions that can furthermore detect biomarkers of psychosis, both in 22q11DS and in the general population. Methods Here we implement a state-of-the-art sliding-window approach to characterize maturation of SC network architecture in a large longitudinal cohort of patients with 22q11DS (110 with 221 visits) and healthy controls (117 with 211 visits). We furthermore propose a new clustering-based approach to group regions according to trajectories of structural connectivity maturation. We correlate measures of SC with development of working memory, a core executive function that is highly affected in both idiopathic psychosis and 22q11DS. Finally, in 22q11DS we explore correlations between SC dysconnectivity and severity of internalizing psychopathology. Results In HCs network architecture underwent a quadratic developmental trajectory maturing up to mid-adolescence. Late-childhood maturation was particularly evident for fronto-parietal cortices, while Default-Mode-Network-related regions showed a more protracted linear development. Working memory performance was positively correlated with network segregation and fronto-parietal connectivity. In 22q11DS, we demonstrate aberrant maturation of SC with disturbed architecture selectively emerging during adolescence and correlating more severe internalizing psychopathology. Patients also presented a lack of typical network development during late-childhood, that was particularly prominent for frontal connectivity. Conclusions Our results suggest that SC maturation may underlie critical cognitive development occurring during late-childhood in healthy controls. Aberrant trajectories of SC maturation may reflect core developmental features of 22q11DS, including disturbed cognitive maturation during childhood and predisposition to internalizing psychopathology and psychosis during adolescence." @default.
• W2803080977 created "2018-05-17" @default.
• W2803080977 creator A5003693672 @default.
• W2803080977 creator A5005881806 @default.
• W2803080977 creator A5011793084 @default.
• W2803080977 creator A5031829911 @default.
• W2803080977 creator A5043034817 @default.
• W2803080977 creator A5054075796 @default.
• W2803080977 creator A5054672338 @default.
• W2803080977 creator A5077913776 @default.
• W2803080977 date "2018-05-18" @default.
• W2803080977 modified "2023-10-14" @default.
• W2803080977 title "Development of Structural Covariance From Childhood to Adolescence: A Longitudinal Study in 22q11.2DS" @default.
• W2803080977 cites W1593120211 @default.
• W2803080977 cites W1735215514 @default.
• W2803080977 cites W1868808864 @default.
• W2803080977 cites W1949681809 @default.
• W2803080977 cites W1968442381 @default.
• W2803080977 cites W1972245323 @default.
• W2803080977 cites W1972412818 @default.
• W2803080977 cites W1974262619 @default.
• W2803080977 cites W1974365824 @default.
• W2803080977 cites W1975282631 @default.
• W2803080977 cites W1983660707 @default.
• W2803080977 cites W1983906797 @default.
• W2803080977 cites W1986644233 @default.
• W2803080977 cites W1987971958 @default.
• W2803080977 cites W1990257603 @default.
• W2803080977 cites W1994239403 @default.
• W2803080977 cites W1994341528 @default.
• W2803080977 cites W1995362640 @default.
• W2803080977 cites W1997403846 @default.
• W2803080977 cites W1997950587 @default.
• W2803080977 cites W1999653836 @default.
• W2803080977 cites W2004469093 @default.
• W2803080977 cites W2005933475 @default.
• W2803080977 cites W2007581301 @default.
• W2803080977 cites W2009650955 @default.
• W2803080977 cites W2011689423 @default.
• W2803080977 cites W2019504975 @default.
• W2803080977 cites W2021895097 @default.
• W2803080977 cites W2025011978 @default.
• W2803080977 cites W2025396411 @default.
• W2803080977 cites W2028881331 @default.
• W2803080977 cites W2030985472 @default.
• W2803080977 cites W2035319691 @default.
• W2803080977 cites W2035599443 @default.
• W2803080977 cites W2035755684 @default.
• W2803080977 cites W2036528467 @default.
• W2803080977 cites W2036785860 @default.
• W2803080977 cites W2037284285 @default.
• W2803080977 cites W2037535091 @default.
• W2803080977 cites W2037761280 @default.
• W2803080977 cites W2045831576 @default.
• W2803080977 cites W2047959911 @default.
• W2803080977 cites W2049130783 @default.
• W2803080977 cites W2049523667 @default.
• W2803080977 cites W2054236226 @default.
• W2803080977 cites W2056083465 @default.
• W2803080977 cites W2061155628 @default.
• W2803080977 cites W2063617559 @default.
• W2803080977 cites W2067257024 @default.
• W2803080977 cites W2072799373 @default.
• W2803080977 cites W2076805502 @default.
• W2803080977 cites W2079041835 @default.
• W2803080977 cites W2082547118 @default.
• W2803080977 cites W2083051698 @default.
• W2803080977 cites W2085066803 @default.
• W2803080977 cites W2095651675 @default.
• W2803080977 cites W2097893532 @default.
• W2803080977 cites W2098391962 @default.
• W2803080977 cites W2099857613 @default.
• W2803080977 cites W2100249822 @default.
• W2803080977 cites W2104613239 @default.
• W2803080977 cites W2105549490 @default.
• W2803080977 cites W2105629360 @default.
• W2803080977 cites W2109181684 @default.
• W2803080977 cites W2110208125 @default.
• W2803080977 cites W2113111292 @default.
• W2803080977 cites W2113359311 @default.
• W2803080977 cites W2113383257 @default.
• W2803080977 cites W2116561060 @default.
• W2803080977 cites W2116658855 @default.
• W2803080977 cites W2121999938 @default.
• W2803080977 cites W2127946463 @default.
• W2803080977 cites W2128912989 @default.
• W2803080977 cites W2133644056 @default.
• W2803080977 cites W2134212997 @default.
• W2803080977 cites W2137367342 @default.
• W2803080977 cites W2139158372 @default.
• W2803080977 cites W2142900310 @default.
• W2803080977 cites W2146264275 @default.
• W2803080977 cites W2146693559 @default.
• W2803080977 cites W2147316388 @default.
• W2803080977 cites W2147546041 @default.
• W2803080977 cites W2148873802 @default.
• W2803080977 cites W2150746895 @default.
• W2803080977 cites W2153234270 @default.
• W2803080977 cites W2154241112 @default.
• W2803080977 cites W2156691676 @default.

• next