Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803118097> ?p ?o ?g. }
- W2803118097 endingPage "1379" @default.
- W2803118097 startingPage "1369" @default.
- W2803118097 abstract "Histone deacetylases are promising therapeutic targets in hematological malignancies. In the work herein, we investigated the effect of chidamide, a new subtype-selective histone deacetylase inhibitor that was independently produced in China, on multiple myeloma and its associated bone diseases using different models. The cytotoxicity of chidamide toward myeloma is due to its induction of cell apoptosis and cell cycle arrest by increasing the levels of caspase family proteins p21 and p27, among others. Furthermore, chidamide exhibited significant cytotoxicity against myeloma cells co-cultured with bone mesenchymal stromal cells and chidamide-pretreated osteoclasts. Importantly, chidamide suppressed osteoclast differentiation and resorption in vitro by dephosphorylating p-ERK, p-p38, p-AKT and p-JNK and inhibiting the expression of Cathepsin K, NFATc1 and c-fos. Finally, chidamide not only prevented tumor-associated bone loss in a disseminated murine model by partially decreasing the tumor burden but also prevented rapid receptor activator of nuclear factor κ-β ligand (RANKL)-induced bone loss in a non-tumor-bearing mouse model. Based on our results, chidamide exerted dual anti-myeloma and bone-protective effects in vitro and in vivo. These findings strongly support the potential clinical use of this drug as a treatment for multiple myeloma in the near future." @default.
- W2803118097 created "2018-06-01" @default.
- W2803118097 creator A5015789291 @default.
- W2803118097 creator A5024244700 @default.
- W2803118097 creator A5030354203 @default.
- W2803118097 creator A5030921116 @default.
- W2803118097 creator A5036246435 @default.
- W2803118097 creator A5039489060 @default.
- W2803118097 creator A5048379858 @default.
- W2803118097 creator A5049692788 @default.
- W2803118097 creator A5069504531 @default.
- W2803118097 creator A5076516025 @default.
- W2803118097 creator A5079526895 @default.
- W2803118097 creator A5084566787 @default.
- W2803118097 creator A5089639451 @default.
- W2803118097 creator A5089986341 @default.
- W2803118097 creator A5090013547 @default.
- W2803118097 date "2018-05-17" @default.
- W2803118097 modified "2023-10-15" @default.
- W2803118097 title "Therapeutic effects of the novel subtype-selective histone deacetylase inhibitor chidamide on myeloma-associated bone disease" @default.
- W2803118097 cites W1968138746 @default.
- W2803118097 cites W1970347037 @default.
- W2803118097 cites W1977328011 @default.
- W2803118097 cites W1979657270 @default.
- W2803118097 cites W1982994807 @default.
- W2803118097 cites W1984534824 @default.
- W2803118097 cites W1988622995 @default.
- W2803118097 cites W1997686829 @default.
- W2803118097 cites W2004288940 @default.
- W2803118097 cites W2011500865 @default.
- W2803118097 cites W2012631080 @default.
- W2803118097 cites W2042876746 @default.
- W2803118097 cites W2054681435 @default.
- W2803118097 cites W2102912734 @default.
- W2803118097 cites W2113056756 @default.
- W2803118097 cites W2148893408 @default.
- W2803118097 cites W2151785974 @default.
- W2803118097 cites W2152181022 @default.
- W2803118097 cites W2155561150 @default.
- W2803118097 cites W2169482785 @default.
- W2803118097 cites W2214176334 @default.
- W2803118097 cites W2298092878 @default.
- W2803118097 cites W2314703289 @default.
- W2803118097 cites W2479187350 @default.
- W2803118097 cites W2480614402 @default.
- W2803118097 cites W2513206021 @default.
- W2803118097 cites W2513456796 @default.
- W2803118097 cites W2551626322 @default.
- W2803118097 cites W2559273903 @default.
- W2803118097 cites W2577527422 @default.
- W2803118097 cites W2601168549 @default.
- W2803118097 cites W2613870926 @default.
- W2803118097 cites W2759655414 @default.
- W2803118097 cites W4211037848 @default.
- W2803118097 doi "https://doi.org/10.3324/haematol.2017.181172" @default.
- W2803118097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6068041" @default.
- W2803118097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29773595" @default.
- W2803118097 hasPublicationYear "2018" @default.
- W2803118097 type Work @default.
- W2803118097 sameAs 2803118097 @default.
- W2803118097 citedByCount "19" @default.
- W2803118097 countsByYear W28031180972018 @default.
- W2803118097 countsByYear W28031180972019 @default.
- W2803118097 countsByYear W28031180972020 @default.
- W2803118097 countsByYear W28031180972021 @default.
- W2803118097 countsByYear W28031180972022 @default.
- W2803118097 countsByYear W28031180972023 @default.
- W2803118097 crossrefType "journal-article" @default.
- W2803118097 hasAuthorship W2803118097A5015789291 @default.
- W2803118097 hasAuthorship W2803118097A5024244700 @default.
- W2803118097 hasAuthorship W2803118097A5030354203 @default.
- W2803118097 hasAuthorship W2803118097A5030921116 @default.
- W2803118097 hasAuthorship W2803118097A5036246435 @default.
- W2803118097 hasAuthorship W2803118097A5039489060 @default.
- W2803118097 hasAuthorship W2803118097A5048379858 @default.
- W2803118097 hasAuthorship W2803118097A5049692788 @default.
- W2803118097 hasAuthorship W2803118097A5069504531 @default.
- W2803118097 hasAuthorship W2803118097A5076516025 @default.
- W2803118097 hasAuthorship W2803118097A5079526895 @default.
- W2803118097 hasAuthorship W2803118097A5084566787 @default.
- W2803118097 hasAuthorship W2803118097A5089639451 @default.
- W2803118097 hasAuthorship W2803118097A5089986341 @default.
- W2803118097 hasAuthorship W2803118097A5090013547 @default.
- W2803118097 hasBestOaLocation W28031180971 @default.
- W2803118097 hasConcept C101990758 @default.
- W2803118097 hasConcept C104317684 @default.
- W2803118097 hasConcept C134018914 @default.
- W2803118097 hasConcept C170493617 @default.
- W2803118097 hasConcept C185592680 @default.
- W2803118097 hasConcept C202751555 @default.
- W2803118097 hasConcept C203014093 @default.
- W2803118097 hasConcept C2776033226 @default.
- W2803118097 hasConcept C2776202225 @default.
- W2803118097 hasConcept C2776364478 @default.
- W2803118097 hasConcept C2778305200 @default.
- W2803118097 hasConcept C2779428903 @default.
- W2803118097 hasConcept C502942594 @default.
- W2803118097 hasConcept C55493867 @default.