FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803124416> ?p ?o ?g. }

• W2803124416 endingPage "1243" @default.
• W2803124416 startingPage "1234" @default.
• W2803124416 abstract "The second extracellular loops (ECL2s) of G-protein-coupled receptors (GPCRs) are often involved in GPCR functions, and their structures have important implications in drug discovery. However, structure prediction of ECL2 is difficult because of its long length and the structural diversity among different GPCRs. In this study, a new ECL2 conformational sampling method involving both template-based and ab initio sampling was developed. Inspired by the observation of similar ECL2 structures of closely related GPCRs, a template-based sampling method employing loop structure templates selected from the structure database was developed. A new metric for evaluating similarity of the target loop to templates was introduced for template selection. An ab initio loop sampling method was also developed to treat cases without highly similar templates. The ab initio method is based on the previously developed fragment assembly and loop closure method. A new sampling component that takes advantage of secondary structure prediction was added. In addition, a conserved disulfide bridge restraining ECL2 conformation was predicted and analytically incorporated into sampling, reducing the effective dimension of the conformational search space. The sampling method was combined with an existing energy function for comparison with previously reported loop structure prediction methods, and the benchmark test demonstrated outstanding performance." @default.
• W2803124416 created "2018-06-01" @default.
• W2803124416 creator A5003116915 @default.
• W2803124416 creator A5011280743 @default.
• W2803124416 creator A5044437309 @default.
• W2803124416 creator A5081678768 @default.
• W2803124416 date "2018-05-22" @default.
• W2803124416 modified "2023-10-17" @default.
• W2803124416 title "GalaxyGPCRloop: Template-Based and <i>Ab Initio</i> Structure Sampling of the Extracellular Loops of G-Protein-Coupled Receptors" @default.
• W2803124416 cites W1682431075 @default.
• W2803124416 cites W1904592173 @default.
• W2803124416 cites W1960000138 @default.
• W2803124416 cites W1971480498 @default.
• W2803124416 cites W1979686694 @default.
• W2803124416 cites W1980374511 @default.
• W2803124416 cites W1981385111 @default.
• W2803124416 cites W1988996356 @default.
• W2803124416 cites W1995726105 @default.
• W2803124416 cites W1998586260 @default.
• W2803124416 cites W1998835042 @default.
• W2803124416 cites W2001130582 @default.
• W2803124416 cites W2002992883 @default.
• W2803124416 cites W2008505479 @default.
• W2803124416 cites W2009774585 @default.
• W2803124416 cites W2011223793 @default.
• W2803124416 cites W2011658408 @default.
• W2803124416 cites W2013785414 @default.
• W2803124416 cites W2015403140 @default.
• W2803124416 cites W2025605951 @default.
• W2803124416 cites W2027408247 @default.
• W2803124416 cites W2042170152 @default.
• W2803124416 cites W2042797284 @default.
• W2803124416 cites W2044145005 @default.
• W2803124416 cites W2048302799 @default.
• W2803124416 cites W2051106500 @default.
• W2803124416 cites W2051434435 @default.
• W2803124416 cites W2070557084 @default.
• W2803124416 cites W2072479057 @default.
• W2803124416 cites W2072708496 @default.
• W2803124416 cites W2106619251 @default.
• W2803124416 cites W2109402847 @default.
• W2803124416 cites W2113875031 @default.
• W2803124416 cites W2129153475 @default.
• W2803124416 cites W2134059200 @default.
• W2803124416 cites W2135689740 @default.
• W2803124416 cites W2137466953 @default.
• W2803124416 cites W2137604324 @default.
• W2803124416 cites W2139475477 @default.
• W2803124416 cites W2140831051 @default.
• W2803124416 cites W2143210482 @default.
• W2803124416 cites W2144362290 @default.
• W2803124416 cites W2151784842 @default.
• W2803124416 cites W2153187042 @default.
• W2803124416 cites W2159128192 @default.
• W2803124416 cites W2159155807 @default.
• W2803124416 cites W2171138378 @default.
• W2803124416 cites W2313815907 @default.
• W2803124416 cites W2342650696 @default.
• W2803124416 cites W2359290780 @default.
• W2803124416 cites W2529629629 @default.
• W2803124416 cites W2552024303 @default.
• W2803124416 cites W2558217333 @default.
• W2803124416 cites W2734771523 @default.
• W2803124416 cites W2744963957 @default.
• W2803124416 cites W2765153686 @default.
• W2803124416 cites W2341291930 @default.
• W2803124416 doi "https://doi.org/10.1021/acs.jcim.8b00148" @default.
• W2803124416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29786430" @default.
• W2803124416 hasPublicationYear "2018" @default.
• W2803124416 type Work @default.
• W2803124416 sameAs 2803124416 @default.
• W2803124416 citedByCount "9" @default.
• W2803124416 countsByYear W28031244162019 @default.
• W2803124416 countsByYear W28031244162021 @default.
• W2803124416 countsByYear W28031244162022 @default.
• W2803124416 countsByYear W28031244162023 @default.
• W2803124416 crossrefType "journal-article" @default.
• W2803124416 hasAuthorship W2803124416A5003116915 @default.
• W2803124416 hasAuthorship W2803124416A5011280743 @default.
• W2803124416 hasAuthorship W2803124416A5044437309 @default.
• W2803124416 hasAuthorship W2803124416A5081678768 @default.
• W2803124416 hasConcept C106131492 @default.
• W2803124416 hasConcept C13280743 @default.
• W2803124416 hasConcept C135285700 @default.
• W2803124416 hasConcept C139489369 @default.
• W2803124416 hasConcept C140779682 @default.
• W2803124416 hasConcept C154945302 @default.
• W2803124416 hasConcept C162324750 @default.
• W2803124416 hasConcept C170493617 @default.
• W2803124416 hasConcept C176217482 @default.
• W2803124416 hasConcept C178790620 @default.
• W2803124416 hasConcept C185592680 @default.
• W2803124416 hasConcept C185798385 @default.
• W2803124416 hasConcept C186060115 @default.
• W2803124416 hasConcept C199360897 @default.
• W2803124416 hasConcept C205649164 @default.
• W2803124416 hasConcept C21547014 @default.
• W2803124416 hasConcept C2781442258 @default.

• next