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- W2803146731 abstract "A series of analogues of potent antiviral perylene nucleoside dUY11 with methylthiomethyl (MTM), azidomethyl (AZM) and HO-C1-4-alkyl-1,2,3-triazol-1,4-diyl groups at 3'-O-position as well as the two products of copper-free alkyne-azide cycloaddition of the AZM derivative were prepared and evaluated against tick-borne encephalitis virus (TBEV). Four compounds (4, 6, 8a, 8b) showed EC50 ≤ 10 nM, thus appearing the most potent TBEV inhibitors to date. Moreover, these nucleosides have higher lipophilicity (clogP) and increased solubility in aq. DMSO vs. parent compound dUY11." @default.
- W2803146731 created "2018-06-01" @default.
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- W2803146731 date "2018-07-01" @default.
- W2803146731 modified "2023-09-23" @default.
- W2803146731 title "3′-O-Substituted 5-(perylen-3-ylethynyl)-2′-deoxyuridines as tick-borne encephalitis virus reproduction inhibitors" @default.
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- W2803146731 doi "https://doi.org/10.1016/j.ejmech.2018.05.040" @default.
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