FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803157002> ?p ?o ?g. }

• W2803157002 endingPage "103.e6" @default.
• W2803157002 startingPage "87" @default.
• W2803157002 abstract "Myeloid-derived suppressor cells (MDSCs) inhibit anti-tumor immunity. Aerobic glycolysis is a hallmark of cancer. However, the link between MDSCs and glycolysis is unknown in patients with triple-negative breast cancer (TNBC). Here, we detect abundant glycolytic activities in human TNBC. In two TNBC mouse models, 4T1 and Py8119, glycolysis restriction inhibits tumor granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) expression and reduces MDSCs. These are accompanied with enhanced T cell immunity, reduced tumor growth and metastasis, and prolonged mouse survival. Mechanistically, glycolysis restriction represses the expression of a specific CCAAT/enhancer-binding protein beta (CEBPB) isoform, liver-enriched activator protein (LAP), via the AMP-activated protein kinase (AMPK)-ULK1 and autophagy pathways, whereas LAP controls G-CSF and GM-CSF expression to support MDSC development. Glycolytic signatures that include lactate dehydrogenase A correlate with high MDSCs and low T cells, and are associated with poor human TNBC outcome. Collectively, tumor glycolysis orchestrates a molecular network of the AMPK-ULK1, autophagy, and CEBPB pathways to affect MDSCs and maintain tumor immunosuppression." @default.
• W2803157002 created "2018-06-01" @default.
• W2803157002 creator A5000432967 @default.
• W2803157002 creator A5001954272 @default.
• W2803157002 creator A5005093063 @default.
• W2803157002 creator A5006253019 @default.
• W2803157002 creator A5036533952 @default.
• W2803157002 creator A5037866135 @default.
• W2803157002 creator A5042612782 @default.
• W2803157002 creator A5046488682 @default.
• W2803157002 creator A5051927389 @default.
• W2803157002 creator A5059956218 @default.
• W2803157002 creator A5064841578 @default.
• W2803157002 creator A5067612393 @default.
• W2803157002 creator A5069778809 @default.
• W2803157002 creator A5075804518 @default.
• W2803157002 creator A5079375938 @default.
• W2803157002 creator A5086113297 @default.
• W2803157002 creator A5088147590 @default.
• W2803157002 creator A5091086026 @default.
• W2803157002 date "2018-07-01" @default.
• W2803157002 modified "2023-10-18" @default.
• W2803157002 title "Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer" @default.
• W2803157002 cites W1561349380 @default.
• W2803157002 cites W1706331960 @default.
• W2803157002 cites W1918384196 @default.
• W2803157002 cites W1970637701 @default.
• W2803157002 cites W1971392223 @default.
• W2803157002 cites W1980860344 @default.
• W2803157002 cites W1984484036 @default.
• W2803157002 cites W1987252739 @default.
• W2803157002 cites W1990061395 @default.
• W2803157002 cites W1990423632 @default.
• W2803157002 cites W1995224853 @default.
• W2803157002 cites W2005895632 @default.
• W2803157002 cites W2021284127 @default.
• W2803157002 cites W2026893794 @default.
• W2803157002 cites W2029582744 @default.
• W2803157002 cites W2033545273 @default.
• W2803157002 cites W2038009564 @default.
• W2803157002 cites W2053122486 @default.
• W2803157002 cites W2053353274 @default.
• W2803157002 cites W2058482682 @default.
• W2803157002 cites W2060672294 @default.
• W2803157002 cites W2070968699 @default.
• W2803157002 cites W2073794835 @default.
• W2803157002 cites W2076570319 @default.
• W2803157002 cites W2079580613 @default.
• W2803157002 cites W2079768195 @default.
• W2803157002 cites W2093773476 @default.
• W2803157002 cites W2096283457 @default.
• W2803157002 cites W2098124513 @default.
• W2803157002 cites W2100039832 @default.
• W2803157002 cites W2102776209 @default.
• W2803157002 cites W2105133921 @default.
• W2803157002 cites W2108086395 @default.
• W2803157002 cites W2110271242 @default.
• W2803157002 cites W2117692326 @default.
• W2803157002 cites W2126028507 @default.
• W2803157002 cites W2130410032 @default.
• W2803157002 cites W2139731402 @default.
• W2803157002 cites W2140612465 @default.
• W2803157002 cites W2146791037 @default.
• W2803157002 cites W2150678612 @default.
• W2803157002 cites W2157250162 @default.
• W2803157002 cites W2158706540 @default.
• W2803157002 cites W2159675211 @default.
• W2803157002 cites W2160551785 @default.
• W2803157002 cites W2163825883 @default.
• W2803157002 cites W2168200596 @default.
• W2803157002 cites W2169729679 @default.
• W2803157002 cites W2171249989 @default.
• W2803157002 cites W2202401513 @default.
• W2803157002 cites W2267844613 @default.
• W2803157002 cites W2292383635 @default.
• W2803157002 cites W2329768139 @default.
• W2803157002 cites W2342880373 @default.
• W2803157002 cites W2346098055 @default.
• W2803157002 cites W2399999257 @default.
• W2803157002 cites W2402636472 @default.
• W2803157002 cites W2510606169 @default.
• W2803157002 cites W2510836433 @default.
• W2803157002 cites W2519020116 @default.
• W2803157002 cites W2519107733 @default.
• W2803157002 cites W271842122 @default.
• W2803157002 cites W2742147437 @default.
• W2803157002 cites W2765354611 @default.
• W2803157002 cites W2769614741 @default.
• W2803157002 cites W2782998220 @default.
• W2803157002 doi "https://doi.org/10.1016/j.cmet.2018.04.022" @default.
• W2803157002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6238219" @default.
• W2803157002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29805099" @default.
• W2803157002 hasPublicationYear "2018" @default.
• W2803157002 type Work @default.
• W2803157002 sameAs 2803157002 @default.
• W2803157002 citedByCount "243" @default.
• W2803157002 countsByYear W28031570022018 @default.
• W2803157002 countsByYear W28031570022019 @default.

• next