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• W2803157802 abstract "Ten novel artemisinin derivatives containing fluorine atoms were synthesized and their structures were confirmed by 1H NMR, 13C NMR and HRMS technologies in this study. The in vitro cytotoxicity against U87MG, SH-SY5Y, MCF-7, MDA-MB-231, A549 and A375 cancer cell lines was evaluated by MTT assay. Compound 9j was the most potent anti-proliferative agent against the human breast cancer MCF-7 cells (IC50 = 2.1 μM). The mechanism of action of compound 9j was further investigated by analysis of cell apoptosis and cell cycle. Compound 9j induced cell apoptosis and arrested cell cycle at G1 phase in MCF-7 cells. Our promising findings indicated that the compound 9j could stand as potential lead compound for further investigation." @default.
• W2803157802 created "2018-06-01" @default.
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• W2803157802 date "2018-07-01" @default.
• W2803157802 modified "2023-10-16" @default.
• W2803157802 title "Design, synthesis and biological evaluation of artemisinin derivatives containing fluorine atoms as anticancer agents" @default.
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• W2803157802 doi "https://doi.org/10.1016/j.bmcl.2018.05.035" @default.
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