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• W2803170955 endingPage "2022" @default.
• W2803170955 startingPage "2016" @default.
• W2803170955 abstract "Abstract Objective Complaints about cognitive dysfunction (CD) reportedly persist in approximately one third of breast cancer patients, but the nature of CD and possible risk factors are unknown. Methods A cross‐sectional, multicenter study was set up at 9 German oncological rehabilitation centers. Objective cognitive performance was assessed by the NeuroCog FX test, a short computerized screening (duration <30 minutes) which assesses working memory, alertness, verbal/figural memory, and language/executive. Patients' test performance was correlated with treatment factors (chemo‐, radiotherapy), subjective performance (FEDA), depression (PHQ‐9), quality of life (EORTC QLQ‐30), and clinical characteristics. Results From February 2013 to December 2014, a clinically homogenous sample of 476 patients was recruited (early tumor stage [T0‐T2]: 93%; node‐negative: 67%; chemotherapy: 61%; radiotherapy: 84%). NeuroCog FX could be administered in 439 patients (92%; median age: 50 [24‐62] years). Patients showed decreased performance in attentional‐executive functions (but not verbal/figural memory) and a 3‐fold rate of CD in terms of below average performance in at least 1 cognitive domain (42%). Approximately 40% of the patients also reported subjective cognitive impairment (FEDA). No therapy‐specific effect on test performance was obtained in the NeuroCog FX test. Conclusions Breast cancer survivors showed objective attentional‐executive and subjective cognitive impairments. No therapy‐specific adverse side effect on objective cognitive performance was found. Depression strongly contributed to objective and subjective cognitive complaints and reduced quality of life." @default.
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• W2803170955 date "2018-06-01" @default.
• W2803170955 modified "2023-10-01" @default.
• W2803170955 title "NeuroCog FX study: A multicenter cohort study on cognitive dysfunction in patients with early breast cancer" @default.
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• W2803170955 doi "https://doi.org/10.1002/pon.4763" @default.
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