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- W2803194041 abstract "Infectious diseases are a significant health concern worldwide. Biologically, they are driven by interactions between the pathogen and host cells. Therefore, understanding the principles of host-pathogen protein-protein interactions (PHIs) is necessary to obtain a deeper understanding of the mechanisms of infections and infectious diseases. The rapid proliferation of omics technologies has facilitated a systematic mapping of transcriptomes and proteomes of both the pathogen and the host; they therefore, have also permitted a deeper understanding of the interactions of pathogens with their host. In this review, we survey different approaches and methods, particularly from a systems biology perspective to characterise and analyse PHIs and how PHI networks have been used to study the complex host-pathogen interplay during an infection. Various studies on the analysis of PHI networks, many of them involving viruses, have shown that pathogens preferentially interact with central and highly connected proteins in the host interactome. A deeper understanding of PHIs, therefore, will also lead to more insights into how to block them and therefore, has potential applications in seeking out new drug targets for anti-viral therapies." @default.
- W2803194041 created "2018-06-01" @default.
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- W2803194041 date "2019-01-01" @default.
- W2803194041 modified "2023-10-14" @default.
- W2803194041 title "Network-Based Analysis of Host-Pathogen Interactions" @default.
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- W2803194041 doi "https://doi.org/10.1016/b978-0-12-809633-8.20170-2" @default.
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