FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803202025> ?p ?o ?g. }

• W2803202025 endingPage "936" @default.
• W2803202025 startingPage "927" @default.
• W2803202025 abstract "Marek’s disease virus (MDV) is a herpesvirus that induces lymphoma and a variety of non-neoplastic syndromes in chickens. Furthermore, very virulent plus (vv+) MDVs induce a form of immunosuppression (late-MDV-IS) that might involve both neoplastic and non-neoplastic mechanisms. The objective of this study was to evaluate whether the attenuation of MDV-induced tumours and late-MDV-IS occurs simultaneously or can be dissociated. The immunosuppressive ability of three viruses derived from vv+ MDV strain 686 (wild-type 686, the somewhat attenuated molecular clone 686-BAC, and the nononcogenic molecular clone lacking the two copies of the oncogene meq 686-BACΔMEQ) was evaluated. Late-MDV-IS was evaluated indirectly by assessing the negative effect of MDV strains on the protection conferred by infectious laryngotracheitis (ILT) vaccines. Our results showed that the ability to induce late-MDV-IS was attenuated before the ability to induce tumours. Strain 686 induced both tumours and late-MDV-IS, 686-BAC induced tumours but did not induce late-MDV-IS and 686-BACΔMEQ did not induce either tumours or late-MDV-IS. Further comparison of strains 686 and 686-BAC revealed that strain 686 reduced the humoral immune responses to ILTV (1132 vs 2167) more severely, showed higher levels of meq transcripts (2.1E+09 vs 4.98E+8) and higher expression of MDV microRNAs (mdv1-miR-M4-5p and mdv1-miR-M2-3p) in the spleen, and further reduced the percentage of CD45+-MHC-I+splenocytes (13 vs32 %) compared to molecular clone 686-BAC. This study suggests that the immunosuppressive ability of MDV might follow a continuous spectrum and only the most virulent MDVs can overcome a certain threshold level and induce clinical MDV-IS in the ILT model." @default.
• W2803202025 created "2018-06-01" @default.
• W2803202025 creator A5027675928 @default.
• W2803202025 creator A5045295351 @default.
• W2803202025 creator A5047098034 @default.
• W2803202025 creator A5058138260 @default.
• W2803202025 creator A5066637007 @default.
• W2803202025 date "2018-07-01" @default.
• W2803202025 modified "2023-09-27" @default.
• W2803202025 title "Differential attenuation of Marek’s disease virus-induced tumours and late-Marek’s disease virus-induced immunosuppression" @default.
• W2803202025 cites W1968250589 @default.
• W2803202025 cites W1976657558 @default.
• W2803202025 cites W200090059 @default.
• W2803202025 cites W2005441956 @default.
• W2803202025 cites W2019805663 @default.
• W2803202025 cites W2031841357 @default.
• W2803202025 cites W2033437630 @default.
• W2803202025 cites W2043104356 @default.
• W2803202025 cites W2046602976 @default.
• W2803202025 cites W2046930347 @default.
• W2803202025 cites W2048994713 @default.
• W2803202025 cites W2070429838 @default.
• W2803202025 cites W2075931546 @default.
• W2803202025 cites W2078829347 @default.
• W2803202025 cites W2090536334 @default.
• W2803202025 cites W2092853593 @default.
• W2803202025 cites W2093873830 @default.
• W2803202025 cites W2100085836 @default.
• W2803202025 cites W2102336622 @default.
• W2803202025 cites W2107676046 @default.
• W2803202025 cites W2108217091 @default.
• W2803202025 cites W2110059232 @default.
• W2803202025 cites W2121982304 @default.
• W2803202025 cites W2127692618 @default.
• W2803202025 cites W2129756449 @default.
• W2803202025 cites W2153987059 @default.
• W2803202025 cites W2159684712 @default.
• W2803202025 cites W2165660663 @default.
• W2803202025 cites W2167492489 @default.
• W2803202025 cites W2171312954 @default.
• W2803202025 cites W2221763099 @default.
• W2803202025 cites W2316926937 @default.
• W2803202025 cites W2397784010 @default.
• W2803202025 cites W2469291289 @default.
• W2803202025 cites W2579513749 @default.
• W2803202025 cites W2583213397 @default.
• W2803202025 cites W4302607050 @default.
• W2803202025 doi "https://doi.org/10.1099/jgv.0.001076" @default.
• W2803202025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29767614" @default.
• W2803202025 hasPublicationYear "2018" @default.
• W2803202025 type Work @default.
• W2803202025 sameAs 2803202025 @default.
• W2803202025 citedByCount "6" @default.
• W2803202025 countsByYear W28032020252019 @default.
• W2803202025 countsByYear W28032020252021 @default.
• W2803202025 countsByYear W28032020252022 @default.
• W2803202025 crossrefType "journal-article" @default.
• W2803202025 hasAuthorship W2803202025A5027675928 @default.
• W2803202025 hasAuthorship W2803202025A5045295351 @default.
• W2803202025 hasAuthorship W2803202025A5047098034 @default.
• W2803202025 hasAuthorship W2803202025A5058138260 @default.
• W2803202025 hasAuthorship W2803202025A5066637007 @default.
• W2803202025 hasBestOaLocation W28032020251 @default.
• W2803202025 hasConcept C104317684 @default.
• W2803202025 hasConcept C159047783 @default.
• W2803202025 hasConcept C203014093 @default.
• W2803202025 hasConcept C2522874641 @default.
• W2803202025 hasConcept C2777852405 @default.
• W2803202025 hasConcept C2780252810 @default.
• W2803202025 hasConcept C54355233 @default.
• W2803202025 hasConcept C60987743 @default.
• W2803202025 hasConcept C81089528 @default.
• W2803202025 hasConcept C86803240 @default.
• W2803202025 hasConcept C8891405 @default.
• W2803202025 hasConcept C89423630 @default.
• W2803202025 hasConceptScore W2803202025C104317684 @default.
• W2803202025 hasConceptScore W2803202025C159047783 @default.
• W2803202025 hasConceptScore W2803202025C203014093 @default.
• W2803202025 hasConceptScore W2803202025C2522874641 @default.
• W2803202025 hasConceptScore W2803202025C2777852405 @default.
• W2803202025 hasConceptScore W2803202025C2780252810 @default.
• W2803202025 hasConceptScore W2803202025C54355233 @default.
• W2803202025 hasConceptScore W2803202025C60987743 @default.
• W2803202025 hasConceptScore W2803202025C81089528 @default.
• W2803202025 hasConceptScore W2803202025C86803240 @default.
• W2803202025 hasConceptScore W2803202025C8891405 @default.
• W2803202025 hasConceptScore W2803202025C89423630 @default.
• W2803202025 hasIssue "7" @default.
• W2803202025 hasLocation W28032020251 @default.
• W2803202025 hasLocation W28032020252 @default.
• W2803202025 hasLocation W28032020253 @default.
• W2803202025 hasOpenAccess W2803202025 @default.
• W2803202025 hasPrimaryLocation W28032020251 @default.
• W2803202025 hasRelatedWork W1986354549 @default.
• W2803202025 hasRelatedWork W2049127623 @default.
• W2803202025 hasRelatedWork W2061872883 @default.
• W2803202025 hasRelatedWork W2062437448 @default.
• W2803202025 hasRelatedWork W2097046100 @default.

• next