Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803209009> ?p ?o ?g. }
- W2803209009 endingPage "337" @default.
- W2803209009 startingPage "329" @default.
- W2803209009 abstract "Albumin is used as a plasma expander in critically ill patients and for several other clinical applications mainly via intravenous infusion. Oral administration of albumin can improve patient compliance although limited oral bioavailability of proteins is still a major challenge. Although nanomaterials have been extensively utilized for improving oral delivery of proteins, albumin has been utilized only as either a model drug or as a carrier for drug delivery. In the current study, for the first time, chitosan nanoparticles have been developed and extensively optimized to improve oral bioavailability of albumin as a therapeutic protein. Several characterizations have been performed for the albumin-loaded nanoparticles (e.g. drug encapsulation efficiency, DSC, FTIR, particle size, zeta potential, morphology, release kinetics, and enzymatic stability). Nanosized spherical particles were prepared and demonstrated high stability over three months either in a powdered form or as suspensions. Sustained release of albumin over time and high enzymatic stability as compared to the free albumin were observed. In vivo, higher serum concentrations of albumin in normal rabbits and cirrhotic rats were attained following oral and intraperitoneal administrations of the albumin-loaded nanoparticles as compared to the free albumin. The nanoparticles developed in the current study might provide efficient nanovehicles for oral administration of therapeutic albumin." @default.
- W2803209009 created "2018-06-01" @default.
- W2803209009 creator A5014496433 @default.
- W2803209009 creator A5024509565 @default.
- W2803209009 creator A5049836899 @default.
- W2803209009 creator A5050587560 @default.
- W2803209009 creator A5055706474 @default.
- W2803209009 creator A5090718553 @default.
- W2803209009 date "2018-06-18" @default.
- W2803209009 modified "2023-09-26" @default.
- W2803209009 title "Development and<i>in vivo</i>evaluation of chitosan nanoparticles for the oral delivery of albumin" @default.
- W2803209009 cites W1518165507 @default.
- W2803209009 cites W1922526566 @default.
- W2803209009 cites W1995785958 @default.
- W2803209009 cites W1997145995 @default.
- W2803209009 cites W2001402205 @default.
- W2803209009 cites W2009249933 @default.
- W2803209009 cites W2009344459 @default.
- W2803209009 cites W2010106434 @default.
- W2803209009 cites W2017303617 @default.
- W2803209009 cites W2019745301 @default.
- W2803209009 cites W2026887211 @default.
- W2803209009 cites W2054164797 @default.
- W2803209009 cites W2072341995 @default.
- W2803209009 cites W2073411471 @default.
- W2803209009 cites W2136150034 @default.
- W2803209009 cites W2138541522 @default.
- W2803209009 cites W2143620889 @default.
- W2803209009 cites W2165988110 @default.
- W2803209009 cites W2326369829 @default.
- W2803209009 cites W2423229203 @default.
- W2803209009 cites W2472538305 @default.
- W2803209009 cites W2507303353 @default.
- W2803209009 cites W2564428140 @default.
- W2803209009 cites W2581368247 @default.
- W2803209009 cites W2582357273 @default.
- W2803209009 cites W2590900400 @default.
- W2803209009 cites W2601524597 @default.
- W2803209009 cites W2604012906 @default.
- W2803209009 cites W2618385844 @default.
- W2803209009 cites W2735137966 @default.
- W2803209009 cites W2747351387 @default.
- W2803209009 cites W2769848125 @default.
- W2803209009 cites W399403874 @default.
- W2803209009 doi "https://doi.org/10.1080/10837450.2018.1479867" @default.
- W2803209009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29781756" @default.
- W2803209009 hasPublicationYear "2018" @default.
- W2803209009 type Work @default.
- W2803209009 sameAs 2803209009 @default.
- W2803209009 citedByCount "16" @default.
- W2803209009 countsByYear W28032090092018 @default.
- W2803209009 countsByYear W28032090092019 @default.
- W2803209009 countsByYear W28032090092020 @default.
- W2803209009 countsByYear W28032090092021 @default.
- W2803209009 countsByYear W28032090092022 @default.
- W2803209009 countsByYear W28032090092023 @default.
- W2803209009 crossrefType "journal-article" @default.
- W2803209009 hasAuthorship W2803209009A5014496433 @default.
- W2803209009 hasAuthorship W2803209009A5024509565 @default.
- W2803209009 hasAuthorship W2803209009A5049836899 @default.
- W2803209009 hasAuthorship W2803209009A5050587560 @default.
- W2803209009 hasAuthorship W2803209009A5055706474 @default.
- W2803209009 hasAuthorship W2803209009A5090718553 @default.
- W2803209009 hasConcept C112705442 @default.
- W2803209009 hasConcept C13245373 @default.
- W2803209009 hasConcept C150903083 @default.
- W2803209009 hasConcept C155672457 @default.
- W2803209009 hasConcept C165616093 @default.
- W2803209009 hasConcept C171250308 @default.
- W2803209009 hasConcept C178790620 @default.
- W2803209009 hasConcept C181389837 @default.
- W2803209009 hasConcept C185592680 @default.
- W2803209009 hasConcept C192562407 @default.
- W2803209009 hasConcept C207001950 @default.
- W2803209009 hasConcept C2776125364 @default.
- W2803209009 hasConcept C2777056448 @default.
- W2803209009 hasConcept C2779732960 @default.
- W2803209009 hasConcept C2779820397 @default.
- W2803209009 hasConcept C43617362 @default.
- W2803209009 hasConcept C55493867 @default.
- W2803209009 hasConcept C71924100 @default.
- W2803209009 hasConcept C86181022 @default.
- W2803209009 hasConcept C86803240 @default.
- W2803209009 hasConcept C98274493 @default.
- W2803209009 hasConceptScore W2803209009C112705442 @default.
- W2803209009 hasConceptScore W2803209009C13245373 @default.
- W2803209009 hasConceptScore W2803209009C150903083 @default.
- W2803209009 hasConceptScore W2803209009C155672457 @default.
- W2803209009 hasConceptScore W2803209009C165616093 @default.
- W2803209009 hasConceptScore W2803209009C171250308 @default.
- W2803209009 hasConceptScore W2803209009C178790620 @default.
- W2803209009 hasConceptScore W2803209009C181389837 @default.
- W2803209009 hasConceptScore W2803209009C185592680 @default.
- W2803209009 hasConceptScore W2803209009C192562407 @default.
- W2803209009 hasConceptScore W2803209009C207001950 @default.
- W2803209009 hasConceptScore W2803209009C2776125364 @default.
- W2803209009 hasConceptScore W2803209009C2777056448 @default.
- W2803209009 hasConceptScore W2803209009C2779732960 @default.