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- W2803214374 abstract "Dyslipidemia is a major risk factor for cardiovascular disease (CVD), which is the leading cause of morbidity and mortality in type 2 diabetes (T2DM). Statins have played a crucial role in its management, but residual risk remains since many patients cannot achieve their desired low-density lipoprotein cholesterol (LDL-C) level and up to 20% of patients are statin-intolerant, experiencing adverse events perceived to be caused by statins, most commonly muscle symptoms. Recently, great advances have been made in nonstatin treatment with ezetimibe, a cholesterol absorption inhibitor, and proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies (mAbs), all showing a proven benefit with an excellent safety profile in cardiovascular outcome trials. This review summarizes the key aspects and the evolving role of these agents in the management of dyslipidemia in patients with T2DM, along with a brief introduction of novel drugs currently in development." @default.
- W2803214374 created "2018-06-01" @default.
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- W2803214374 date "2018-05-24" @default.
- W2803214374 modified "2023-09-27" @default.
- W2803214374 title "Management of Dyslipidemia in Type 2 Diabetes: Recent Advances in Nonstatin Treatment" @default.
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- W2803214374 doi "https://doi.org/10.3390/diseases6020044" @default.
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