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• W2803220003 abstract "Summary Background The prevalence of sesame food allergy ( SFA ) has increased over recent years, with the potential of anaphylactic reactions upon exposure. Oral food challenge ( OFC ) remains the diagnostic standard, yet its implementation may be risky. Commercial skin prick tests ( SPT ) have a low sensitivity. Investigation of alternate diagnostic methods is warranted. Objective To evaluate the utility of SPT and the basophil activation test ( BAT ) for SFA diagnosis. Methods Eighty‐two patients with suspected SFA completed an open OFC to sesame or reported a recent confirmed reaction. Patients were administered skin prick tests ( SPT ) with commercial sesame seed extract ( CSSE ) and a high protein concentration sesame extract ( HPSE ) (100 mg/mL protein). Whole blood from 80 patients was stimulated with sesame seed extract (40‐10 000 ng/mL protein) for BAT ), assessing CD 63 and CD 203c as activation markers. Results Sixty patients (73%) had IgE‐mediated reactions to sesame, and 22 (27%) did not react. Receiver operating characteristic ( ROC ) curve analysis demonstrated an area under the curve ( AUC ) of 0.87 for HPSE ‐ SPT and 0.66 for CSSE ‐ SPT . At 1000 ng/mL of sesame protein, induction of CD 63 and CD 203c was weakly but significantly associated with OFC eliciting dose by rank (Spearman's rho = −.42 ( P < .01) and −.35 ( P < .05) for CD 63 and CD 203c, respectively). By ROC analysis, the AUC was 0.86 for CD 63 and was 0.81 for CD 203c sesame‐induced basophil expression. Using HPSE ‐ SPT as a first test to definitively diagnose (n = 24) or rule‐out (n = 5) SFA and BAT as a second test to diagnose the remainder results in the correct classification of 73 of 80 (91%) patients, leaving one false negative and 4 false positive patients. Two BAT non‐responders remain unclassified by this algorithm. Conclusions & Clinical Relevance While prospective cohort validation is necessary, joint utilization of BAT and SPT with HPSE extract may obviate the need for OFC in most SFA patients." @default.
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• W2803220003 date "2018-06-13" @default.
• W2803220003 modified "2023-10-10" @default.
• W2803220003 title "Evaluation of the basophil activation test and skin prick testing for the diagnosis of sesame food allergy" @default.
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• W2803220003 doi "https://doi.org/10.1111/cea.13174" @default.
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