FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803235607> ?p ?o ?g. }

• W2803235607 endingPage "675" @default.
• W2803235607 startingPage "668" @default.
• W2803235607 abstract "Secretion of very low density lipoprotein (VLDL) by the liver is an important physiological process; however, the rate of VLDL secretion is determined by its transport from the endoplasmic reticulum (ER) to the Golgi. This transport event is facilitated by a specialized ER-derived vesicle, the VLDL transport vesicle (VTV). We have reported earlier a detailed VTV proteome, which revealed that reticulon 3 (RTN3) is uniquely present in the VTV. Our immunoblotting and electron microscopic data demonstrate that RTN3 is enriched in the VTV; however, other ER-derived vesicles do not contain RTN3. Co-immunoprecipitation data coupled with confocal microscopic analyses strongly suggest that RTN3 interacts with VLDL core protein, apoB100, at the ER level. Our data show that either blocking of RTN3 using specific antibodies or RTN3 knockdown resulted in significant reduction in VTV biogenesis from hepatic ER membranes. Additionally, VLDL secretion from hepatocytes was significantly decreased when RTN3 was silenced by RTN3 siRNA. We conclude that RTN3 regulates VLDL secretion by controlling VTV-mediated ER-to-Golgi transport of nascent VLDL." @default.
• W2803235607 created "2018-06-01" @default.
• W2803235607 creator A5001436896 @default.
• W2803235607 creator A5043056750 @default.
• W2803235607 creator A5079914177 @default.
• W2803235607 date "2018-07-01" @default.
• W2803235607 modified "2023-09-30" @default.
• W2803235607 title "Reticulon 3 regulates very low density lipoprotein secretion by controlling very low density lipoprotein transport vesicle biogenesis" @default.
• W2803235607 cites W1498848540 @default.
• W2803235607 cites W1612371477 @default.
• W2803235607 cites W1646890589 @default.
• W2803235607 cites W1974375799 @default.
• W2803235607 cites W1979560290 @default.
• W2803235607 cites W1990731739 @default.
• W2803235607 cites W1991501163 @default.
• W2803235607 cites W2008834179 @default.
• W2803235607 cites W2011523747 @default.
• W2803235607 cites W2011567565 @default.
• W2803235607 cites W2029152767 @default.
• W2803235607 cites W2047261885 @default.
• W2803235607 cites W2048262458 @default.
• W2803235607 cites W2050842751 @default.
• W2803235607 cites W2061829977 @default.
• W2803235607 cites W2068111737 @default.
• W2803235607 cites W2070787805 @default.
• W2803235607 cites W2071547802 @default.
• W2803235607 cites W2080508595 @default.
• W2803235607 cites W2081249929 @default.
• W2803235607 cites W2096326095 @default.
• W2803235607 cites W2097089354 @default.
• W2803235607 cites W2097330469 @default.
• W2803235607 cites W2122433263 @default.
• W2803235607 cites W2126359017 @default.
• W2803235607 cites W2130085010 @default.
• W2803235607 cites W2141225101 @default.
• W2803235607 cites W2151276108 @default.
• W2803235607 cites W2151400756 @default.
• W2803235607 cites W2153624331 @default.
• W2803235607 cites W2155611012 @default.
• W2803235607 cites W2161573536 @default.
• W2803235607 cites W2329147786 @default.
• W2803235607 cites W2414447301 @default.
• W2803235607 cites W2779640875 @default.
• W2803235607 doi "https://doi.org/10.1139/cjpp-2018-0077" @default.
• W2803235607 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6816505" @default.
• W2803235607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29756473" @default.
• W2803235607 hasPublicationYear "2018" @default.
• W2803235607 type Work @default.
• W2803235607 sameAs 2803235607 @default.
• W2803235607 citedByCount "9" @default.
• W2803235607 countsByYear W28032356072020 @default.
• W2803235607 countsByYear W28032356072021 @default.
• W2803235607 countsByYear W28032356072022 @default.
• W2803235607 countsByYear W28032356072023 @default.
• W2803235607 crossrefType "journal-article" @default.
• W2803235607 hasAuthorship W2803235607A5001436896 @default.
• W2803235607 hasAuthorship W2803235607A5043056750 @default.
• W2803235607 hasAuthorship W2803235607A5079914177 @default.
• W2803235607 hasBestOaLocation W28032356072 @default.
• W2803235607 hasConcept C104317684 @default.
• W2803235607 hasConcept C119062480 @default.
• W2803235607 hasConcept C130316041 @default.
• W2803235607 hasConcept C131934819 @default.
• W2803235607 hasConcept C158617107 @default.
• W2803235607 hasConcept C167019083 @default.
• W2803235607 hasConcept C185592680 @default.
• W2803235607 hasConcept C2778163477 @default.
• W2803235607 hasConcept C2780072125 @default.
• W2803235607 hasConcept C41625074 @default.
• W2803235607 hasConcept C49039625 @default.
• W2803235607 hasConcept C55493867 @default.
• W2803235607 hasConcept C57581600 @default.
• W2803235607 hasConcept C71829478 @default.
• W2803235607 hasConcept C8243546 @default.
• W2803235607 hasConcept C86803240 @default.
• W2803235607 hasConcept C95444343 @default.
• W2803235607 hasConceptScore W2803235607C104317684 @default.
• W2803235607 hasConceptScore W2803235607C119062480 @default.
• W2803235607 hasConceptScore W2803235607C130316041 @default.
• W2803235607 hasConceptScore W2803235607C131934819 @default.
• W2803235607 hasConceptScore W2803235607C158617107 @default.
• W2803235607 hasConceptScore W2803235607C167019083 @default.
• W2803235607 hasConceptScore W2803235607C185592680 @default.
• W2803235607 hasConceptScore W2803235607C2778163477 @default.
• W2803235607 hasConceptScore W2803235607C2780072125 @default.
• W2803235607 hasConceptScore W2803235607C41625074 @default.
• W2803235607 hasConceptScore W2803235607C49039625 @default.
• W2803235607 hasConceptScore W2803235607C55493867 @default.
• W2803235607 hasConceptScore W2803235607C57581600 @default.
• W2803235607 hasConceptScore W2803235607C71829478 @default.
• W2803235607 hasConceptScore W2803235607C8243546 @default.
• W2803235607 hasConceptScore W2803235607C86803240 @default.
• W2803235607 hasConceptScore W2803235607C95444343 @default.
• W2803235607 hasIssue "7" @default.
• W2803235607 hasLocation W28032356071 @default.
• W2803235607 hasLocation W28032356072 @default.
• W2803235607 hasLocation W28032356073 @default.
• W2803235607 hasLocation W28032356074 @default.

• next