FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803250545> ?p ?o ?g. }

• W2803250545 endingPage "1691" @default.
• W2803250545 startingPage "1686" @default.
• W2803250545 abstract "Elevated expression of the c-Met receptor plays a crucial role in cancers. In non-small cell lung cancer (NSCLC), aberrant activation of the c-Met signaling pathway contributes to tumorigenesis and cancer progression and may mediate acquired resistance to epidermal growth factor receptor-targeted therapy. c-Met is therefore emerging as a promising therapeutic target for NSCLC, and methods for noninvasive in vivo assessment of c-Met expression would improve NSCLC treatment and diagnosis. Methods: We developed a new c-Met-binding peptide (cMBP) radiotracer, 99mTc-hydrazine nicotinamide (HYNIC)-cMBP, for SPECT imaging. Cell uptake assays were performed on 2 NSCLC cell lines with different c-Met expressions: H1993 (high expression) and H1299 (no expression). In vivo tumor specificity was assessed by SPECT imaging in tumor-bearing mice at 0.5, 1, 2, and 4 h after injection of the probe. Blocking assays, biodistribution, and autoradiography were also conducted to determine probe specificity. Results:99mTc-HYNIC-cMBP was prepared with high efficiency and showed higher uptake in H1993 cells than in H1299 cells. Biodistribution and autoradiography also showed significantly higher percentages of the injected dose for 99mTc-HYNIC-cMBP in H1993 tumors than in H1299 tumors at 0.5 h (4.74 ± 1.43%/g and 1.00 ± 0.37%/g, respectively; P < 0.05). H1993 tumors were clearly visualized at 0.5 h in SPECT images, whereas H1299 tumors were not observed at any time. The specificity of 99mTc-HYNIC-cMBP for c-Met was demonstrated by a competitive block with an excess of nonradiolabeled peptide. Conclusion: For c-Met-targeted SPECT imaging of NSCLC, we developed 99mTc-HYNIC-cMBP, a tracer that specifically binds to c-Met with favorable pharmacokinetics in vitro and in vivo." @default.
• W2803250545 created "2018-06-01" @default.
• W2803250545 creator A5012123976 @default.
• W2803250545 creator A5013254367 @default.
• W2803250545 creator A5020360851 @default.
• W2803250545 creator A5021462836 @default.
• W2803250545 creator A5025202937 @default.
• W2803250545 creator A5026108587 @default.
• W2803250545 creator A5037085188 @default.
• W2803250545 creator A5043490198 @default.
• W2803250545 creator A5052448080 @default.
• W2803250545 creator A5057369590 @default.
• W2803250545 date "2018-05-18" @default.
• W2803250545 modified "2023-10-16" @default.
• W2803250545 title "Development of a SPECT Tracer to Image c-Met Expression in a Xenograft Model of Non–Small Cell Lung Cancer" @default.
• W2803250545 cites W1980427890 @default.
• W2803250545 cites W1984275251 @default.
• W2803250545 cites W1996489028 @default.
• W2803250545 cites W1997655235 @default.
• W2803250545 cites W1998971866 @default.
• W2803250545 cites W2004882167 @default.
• W2803250545 cites W2012345824 @default.
• W2803250545 cites W2034730058 @default.
• W2803250545 cites W2048502161 @default.
• W2803250545 cites W2055586791 @default.
• W2803250545 cites W2055787036 @default.
• W2803250545 cites W2062110561 @default.
• W2803250545 cites W2069421644 @default.
• W2803250545 cites W2073597573 @default.
• W2803250545 cites W2080917628 @default.
• W2803250545 cites W2087684390 @default.
• W2803250545 cites W2094337993 @default.
• W2803250545 cites W2094921617 @default.
• W2803250545 cites W2120172300 @default.
• W2803250545 cites W2124101088 @default.
• W2803250545 cites W2131619253 @default.
• W2803250545 cites W2136390065 @default.
• W2803250545 cites W2136506851 @default.
• W2803250545 cites W2154349915 @default.
• W2803250545 cites W2161254570 @default.
• W2803250545 cites W2166521422 @default.
• W2803250545 cites W2255650047 @default.
• W2803250545 cites W2316668255 @default.
• W2803250545 cites W2346482118 @default.
• W2803250545 cites W2511958698 @default.
• W2803250545 cites W2530670224 @default.
• W2803250545 cites W2562169753 @default.
• W2803250545 cites W2566863750 @default.
• W2803250545 cites W2621990038 @default.
• W2803250545 cites W2774018970 @default.
• W2803250545 cites W888121792 @default.
• W2803250545 doi "https://doi.org/10.2967/jnumed.117.206730" @default.
• W2803250545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29777004" @default.
• W2803250545 hasPublicationYear "2018" @default.
• W2803250545 type Work @default.
• W2803250545 sameAs 2803250545 @default.
• W2803250545 citedByCount "14" @default.
• W2803250545 countsByYear W28032505452018 @default.
• W2803250545 countsByYear W28032505452019 @default.
• W2803250545 countsByYear W28032505452020 @default.
• W2803250545 countsByYear W28032505452021 @default.
• W2803250545 countsByYear W28032505452022 @default.
• W2803250545 countsByYear W28032505452023 @default.
• W2803250545 crossrefType "journal-article" @default.
• W2803250545 hasAuthorship W2803250545A5012123976 @default.
• W2803250545 hasAuthorship W2803250545A5013254367 @default.
• W2803250545 hasAuthorship W2803250545A5020360851 @default.
• W2803250545 hasAuthorship W2803250545A5021462836 @default.
• W2803250545 hasAuthorship W2803250545A5025202937 @default.
• W2803250545 hasAuthorship W2803250545A5026108587 @default.
• W2803250545 hasAuthorship W2803250545A5037085188 @default.
• W2803250545 hasAuthorship W2803250545A5043490198 @default.
• W2803250545 hasAuthorship W2803250545A5052448080 @default.
• W2803250545 hasAuthorship W2803250545A5057369590 @default.
• W2803250545 hasBestOaLocation W28032505451 @default.
• W2803250545 hasConcept C121608353 @default.
• W2803250545 hasConcept C126322002 @default.
• W2803250545 hasConcept C142724271 @default.
• W2803250545 hasConcept C150903083 @default.
• W2803250545 hasConcept C185592680 @default.
• W2803250545 hasConcept C207001950 @default.
• W2803250545 hasConcept C2776256026 @default.
• W2803250545 hasConcept C2777807558 @default.
• W2803250545 hasConcept C2984398910 @default.
• W2803250545 hasConcept C2989005 @default.
• W2803250545 hasConcept C502942594 @default.
• W2803250545 hasConcept C555283112 @default.
• W2803250545 hasConcept C71924100 @default.
• W2803250545 hasConcept C86803240 @default.
• W2803250545 hasConceptScore W2803250545C121608353 @default.
• W2803250545 hasConceptScore W2803250545C126322002 @default.
• W2803250545 hasConceptScore W2803250545C142724271 @default.
• W2803250545 hasConceptScore W2803250545C150903083 @default.
• W2803250545 hasConceptScore W2803250545C185592680 @default.
• W2803250545 hasConceptScore W2803250545C207001950 @default.
• W2803250545 hasConceptScore W2803250545C2776256026 @default.
• W2803250545 hasConceptScore W2803250545C2777807558 @default.
• W2803250545 hasConceptScore W2803250545C2984398910 @default.

• next