Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803268510> ?p ?o ?g. }
- W2803268510 endingPage "153" @default.
- W2803268510 startingPage "153" @default.
- W2803268510 abstract "Dysregulated activity of helicase eIF4A drives transformation to and maintenance of cancer cell phenotype by reprogramming cellular translation. Interleukin 24 (IL-24) is a tumor-suppressing protein, which has the ability to inhibit angiogenesis, sensitize cancer cells to chemotherapy, and induce cancer cell-specific apoptosis. In this study, we found that eIF4A is inhibited by IL-24. Consequently, selective reduction of translation was observed for mRNAs harboring strong secondary structures in their 5′-untranslated regions (5′UTRs). These mRNAs encode proteins, which function in cell survival and proliferation. Consistently, overexpression of eIF4A conferred cancer cells with resistance to IL-24-induced cell death. It has been established that inhibition of eIF4A triggers mitochondrial-mediated apoptosis. We showed that IL-24 induces eIF4A-dependent mitochondrial depolarization. We also showed that IL-24 induces Sigma 1 Receptor-dependent eIF4A down-regulation and mitochondrial depolarization. Thus, the progress of apoptosis triggered by IL-24 is characterized by a complex program of changes in regulation of several initiation factors, including the eIF4A." @default.
- W2803268510 created "2018-06-01" @default.
- W2803268510 creator A5001362625 @default.
- W2803268510 creator A5020661635 @default.
- W2803268510 creator A5059781163 @default.
- W2803268510 creator A5063196856 @default.
- W2803268510 creator A5064091905 @default.
- W2803268510 creator A5064666735 @default.
- W2803268510 creator A5073881400 @default.
- W2803268510 date "2018-05-22" @default.
- W2803268510 modified "2023-09-27" @default.
- W2803268510 title "Eukaryotic Translation Initiation Factor 4A Down-Regulation Mediates Interleukin-24-Induced Apoptosis through Inhibition of Translation" @default.
- W2803268510 cites W1551673807 @default.
- W2803268510 cites W1975206317 @default.
- W2803268510 cites W1999381474 @default.
- W2803268510 cites W2004170517 @default.
- W2803268510 cites W2020716652 @default.
- W2803268510 cites W2040885133 @default.
- W2803268510 cites W2043654385 @default.
- W2803268510 cites W2056348907 @default.
- W2803268510 cites W2062972527 @default.
- W2803268510 cites W2077599120 @default.
- W2803268510 cites W2082082706 @default.
- W2803268510 cites W2086079901 @default.
- W2803268510 cites W2089716875 @default.
- W2803268510 cites W2096184369 @default.
- W2803268510 cites W2119549758 @default.
- W2803268510 cites W2145502099 @default.
- W2803268510 cites W2152740213 @default.
- W2803268510 cites W2165341580 @default.
- W2803268510 cites W2165848665 @default.
- W2803268510 cites W2170815810 @default.
- W2803268510 cites W2271406622 @default.
- W2803268510 cites W2299936619 @default.
- W2803268510 cites W2394834163 @default.
- W2803268510 cites W2411243814 @default.
- W2803268510 cites W2419150381 @default.
- W2803268510 cites W2427010553 @default.
- W2803268510 cites W2544544592 @default.
- W2803268510 cites W2562008458 @default.
- W2803268510 cites W2611437687 @default.
- W2803268510 cites W2624383031 @default.
- W2803268510 cites W2743505784 @default.
- W2803268510 cites W2758905589 @default.
- W2803268510 cites W2770000599 @default.
- W2803268510 cites W2770320742 @default.
- W2803268510 cites W2792867092 @default.
- W2803268510 doi "https://doi.org/10.3390/cancers10050153" @default.
- W2803268510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5977126" @default.
- W2803268510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29786657" @default.
- W2803268510 hasPublicationYear "2018" @default.
- W2803268510 type Work @default.
- W2803268510 sameAs 2803268510 @default.
- W2803268510 citedByCount "8" @default.
- W2803268510 countsByYear W28032685102019 @default.
- W2803268510 countsByYear W28032685102020 @default.
- W2803268510 countsByYear W28032685102021 @default.
- W2803268510 countsByYear W28032685102022 @default.
- W2803268510 countsByYear W28032685102023 @default.
- W2803268510 crossrefType "journal-article" @default.
- W2803268510 hasAuthorship W2803268510A5001362625 @default.
- W2803268510 hasAuthorship W2803268510A5020661635 @default.
- W2803268510 hasAuthorship W2803268510A5059781163 @default.
- W2803268510 hasAuthorship W2803268510A5063196856 @default.
- W2803268510 hasAuthorship W2803268510A5064091905 @default.
- W2803268510 hasAuthorship W2803268510A5064666735 @default.
- W2803268510 hasAuthorship W2803268510A5073881400 @default.
- W2803268510 hasBestOaLocation W28032685101 @default.
- W2803268510 hasConcept C104317684 @default.
- W2803268510 hasConcept C105580179 @default.
- W2803268510 hasConcept C149364088 @default.
- W2803268510 hasConcept C153911025 @default.
- W2803268510 hasConcept C161295673 @default.
- W2803268510 hasConcept C190283241 @default.
- W2803268510 hasConcept C31573885 @default.
- W2803268510 hasConcept C4718897 @default.
- W2803268510 hasConcept C502942594 @default.
- W2803268510 hasConcept C54355233 @default.
- W2803268510 hasConcept C62493599 @default.
- W2803268510 hasConcept C86803240 @default.
- W2803268510 hasConcept C95444343 @default.
- W2803268510 hasConcept C99348085 @default.
- W2803268510 hasConceptScore W2803268510C104317684 @default.
- W2803268510 hasConceptScore W2803268510C105580179 @default.
- W2803268510 hasConceptScore W2803268510C149364088 @default.
- W2803268510 hasConceptScore W2803268510C153911025 @default.
- W2803268510 hasConceptScore W2803268510C161295673 @default.
- W2803268510 hasConceptScore W2803268510C190283241 @default.
- W2803268510 hasConceptScore W2803268510C31573885 @default.
- W2803268510 hasConceptScore W2803268510C4718897 @default.
- W2803268510 hasConceptScore W2803268510C502942594 @default.
- W2803268510 hasConceptScore W2803268510C54355233 @default.
- W2803268510 hasConceptScore W2803268510C62493599 @default.
- W2803268510 hasConceptScore W2803268510C86803240 @default.
- W2803268510 hasConceptScore W2803268510C95444343 @default.
- W2803268510 hasConceptScore W2803268510C99348085 @default.
- W2803268510 hasIssue "5" @default.
- W2803268510 hasLocation W28032685101 @default.