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- W2803284911 abstract "Background: Fracture repair is a complex process. Currently, about 5-10% of all 7.9 million fractures in the U.S. show complications in terms of impaired healing or non-union. This implies a reduction of quality of life for any affected patient and results in a massive economic burden for the society. At present, no pharmacological treatment is available and treatment generally implies a surgical procedure. Intermittent administration of parathyroid hormone (PTH) has been demonstrated to improve bone mass and to increase bone formation. Question/purposes: We examined the effect of PTH on different regimes of the fracture healing process of healthy rats. Methods: 36 healthy female Sprage Dawley rats were divided into 3 groups. After bilateral transverse metaphyseal tibial osteotomy one group was treated with placebo. The other two groups were treated with 40μg/kg PTH from day one or day seven after osteotomy. Rats were treated 5x/week over a period of five weeks. Four fluorescence dyes were injected according to a predefined scheme. After decapitation specimens were harvested. One tibia was used for biomechanical testing, the other one for histological analysis. Results: Biomechanical properties of bone improved significantly in both treatment groups but did not defer significantly among them. Both treatment groups showed a significant increase in average trabecular thickness and areal bone density of the distal trabecular area whereas dorsal cortical thickness decreased significantly when compared to control group. Callus area increased significantly during early fracture repair for the group which received PTH from day 7. Conculsions: The significant increase of trabecular thickness and areal bone density at trabecular bone for both PTH-treated groups resulted in superior biomechanical properties when compared to placebo group. In addition, callus area increased for the group receiving PTH from the 7. post-operative day showing a positive effect of PTH on early callus formation. A higher load bearing capacity may result in earlier mobilization after fracture and therefore a reduction of costs due to longer hospitalization." @default.
- W2803284911 created "2018-06-01" @default.
- W2803284911 creator A5054678422 @default.
- W2803284911 date "2022-02-20" @default.
- W2803284911 modified "2023-09-30" @default.
- W2803284911 title "Einfluss von Parathormon auf die Frakturheilung der proximalen metaphysären Tibia im Rattentiermodell" @default.
- W2803284911 doi "https://doi.org/10.53846/goediss-1604" @default.
- W2803284911 hasPublicationYear "2022" @default.
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