FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803301327> ?p ?o ?g. }

• W2803301327 abstract "Although there are available therapies as surgery, chemotherapy and radiation, glioblastoma (GBM) still has been considered as the most common and overwhelming primary tumor of brain. In GBM, the brain glioma stem cells (BGSCs) were identified and played a crucial role in resistance of GBM to conventional therapies described above. PAX3 was previously identified by our group as a diagnostic/prognostic marker and a therapeutic regulator in the therapy of GBM. Here, we hypothesized PAX3/p53 axis promoted the process of differentiation, regulating to the cancer stem cell properties, such as proliferation and migration. The correlation between PAX3 and p53 in GBM were firstly clarified. Immunofluorescence of p53 was shown activated following BGSCs differentiation. We further identified that PAX3 might specifically bind to the promoter of p53 gene, and transcriptionally repressed p53 expression. ChIP assay further confirmed that PAX3/p53 axis regulated the differentiation process of BGSCs. Then, the function of PAX3 in BGSCs were sequentially investigated in vitro and in vivo. Ectopic PAX3 expression promoted BGSCs growth and migration while PAX3 knockdown suppresses BGSCs growth, migration in vitro and in vivo. Similar to PAX3 overexpression, p53 inhibition also showed increase in growth and migration of differentiated BGSCs. Regarding the functional interaction between PAX3 and p53, PAX3 knockdown-mediated decrease in proliferation was partially rescued by p53 inhibition. Hypoxia significantly promoted the migration potential of BGSCs. In addition, HIF-1α might be a potential upstream regulator of PAX3 in differentiated BGSCs under hypoxia. Our work may provide a supplementary mechanism in regulation of the BGSCs differentiation and their functions, which should provide novel therapeutic targets for GBM in future." @default.
• W2803301327 created "2018-06-01" @default.
• W2803301327 creator A5001376866 @default.
• W2803301327 creator A5016483091 @default.
• W2803301327 creator A5028433300 @default.
• W2803301327 creator A5054380620 @default.
• W2803301327 creator A5062499295 @default.
• W2803301327 creator A5072795022 @default.
• W2803301327 creator A5083576555 @default.
• W2803301327 creator A5083729859 @default.
• W2803301327 creator A5086371835 @default.
• W2803301327 date "2018-06-08" @default.
• W2803301327 modified "2023-09-25" @default.
• W2803301327 title "Transcriptional Repression of p53 by PAX3 Contributes to Gliomagenesis and Differentiation of Glioma Stem Cells" @default.
• W2803301327 cites W1487355433 @default.
• W2803301327 cites W1793758766 @default.
• W2803301327 cites W1884616035 @default.
• W2803301327 cites W1966546969 @default.
• W2803301327 cites W1969043956 @default.
• W2803301327 cites W1970240256 @default.
• W2803301327 cites W1976840830 @default.
• W2803301327 cites W1977888767 @default.
• W2803301327 cites W1985293431 @default.
• W2803301327 cites W1992781718 @default.
• W2803301327 cites W1992947462 @default.
• W2803301327 cites W1994901446 @default.
• W2803301327 cites W1999782260 @default.
• W2803301327 cites W2012450328 @default.
• W2803301327 cites W2017654880 @default.
• W2803301327 cites W2030533809 @default.
• W2803301327 cites W2032349293 @default.
• W2803301327 cites W2037911497 @default.
• W2803301327 cites W2039075677 @default.
• W2803301327 cites W2039994380 @default.
• W2803301327 cites W2040915596 @default.
• W2803301327 cites W2046103294 @default.
• W2803301327 cites W2063602990 @default.
• W2803301327 cites W2066379425 @default.
• W2803301327 cites W2073237741 @default.
• W2803301327 cites W2080838269 @default.
• W2803301327 cites W2083081144 @default.
• W2803301327 cites W2083098015 @default.
• W2803301327 cites W2092695767 @default.
• W2803301327 cites W2092835558 @default.
• W2803301327 cites W2108491406 @default.
• W2803301327 cites W2109610561 @default.
• W2803301327 cites W2112659914 @default.
• W2803301327 cites W2119593356 @default.
• W2803301327 cites W2123509170 @default.
• W2803301327 cites W2128450583 @default.
• W2803301327 cites W2133460396 @default.
• W2803301327 cites W2144328367 @default.
• W2803301327 cites W2147673571 @default.
• W2803301327 cites W2154312278 @default.
• W2803301327 cites W2170321459 @default.
• W2803301327 cites W2224717864 @default.
• W2803301327 cites W2283995306 @default.
• W2803301327 cites W2308789672 @default.
• W2803301327 cites W2366536035 @default.
• W2803301327 cites W2460346852 @default.
• W2803301327 cites W2514490172 @default.
• W2803301327 cites W2551376961 @default.
• W2803301327 cites W2559423762 @default.
• W2803301327 cites W2589879570 @default.
• W2803301327 cites W2593998504 @default.
• W2803301327 cites W2594788664 @default.
• W2803301327 cites W2601374730 @default.
• W2803301327 cites W2605179166 @default.
• W2803301327 cites W2752942423 @default.
• W2803301327 cites W2761941966 @default.
• W2803301327 cites W29398439 @default.
• W2803301327 doi "https://doi.org/10.3389/fnmol.2018.00187" @default.
• W2803301327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6003214" @default.
• W2803301327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29937714" @default.
• W2803301327 hasPublicationYear "2018" @default.
• W2803301327 type Work @default.
• W2803301327 sameAs 2803301327 @default.
• W2803301327 citedByCount "12" @default.
• W2803301327 countsByYear W28033013272019 @default.
• W2803301327 countsByYear W28033013272020 @default.
• W2803301327 countsByYear W28033013272021 @default.
• W2803301327 countsByYear W28033013272022 @default.
• W2803301327 countsByYear W28033013272023 @default.
• W2803301327 crossrefType "journal-article" @default.
• W2803301327 hasAuthorship W2803301327A5001376866 @default.
• W2803301327 hasAuthorship W2803301327A5016483091 @default.
• W2803301327 hasAuthorship W2803301327A5028433300 @default.
• W2803301327 hasAuthorship W2803301327A5054380620 @default.
• W2803301327 hasAuthorship W2803301327A5062499295 @default.
• W2803301327 hasAuthorship W2803301327A5072795022 @default.
• W2803301327 hasAuthorship W2803301327A5083576555 @default.
• W2803301327 hasAuthorship W2803301327A5083729859 @default.
• W2803301327 hasAuthorship W2803301327A5086371835 @default.
• W2803301327 hasBestOaLocation W28033013271 @default.
• W2803301327 hasConcept C104317684 @default.
• W2803301327 hasConcept C148738053 @default.
• W2803301327 hasConcept C150194340 @default.
• W2803301327 hasConcept C168609215 @default.
• W2803301327 hasConcept C173396325 @default.
• W2803301327 hasConcept C186310378 @default.

• next