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- W2803305487 endingPage "84" @default.
- W2803305487 startingPage "73" @default.
- W2803305487 abstract "With 4 mg folic acid daily, it may take 20 weeks to reach red-blood-cell folate levels between 1050 and 1340 nmol/L, optimal for reduction of the neural tube defect risk. Therefore, folic acid supplementation should be started 5–6 months before conception. The residual risk with optimal red-blood-cell folate levels is reportedly 4.5 per 10,000 total births. The residual risk in pooled data from countries with mandatory folic acid fortification is 7.5 per 10,000 pregnancies, regardless of pre-fortification rates. European monitoring of folate intake with questionnaires should be replaced by periodic measurements of red-blood-cell folate. The risk of folate intake >1 mg/day does not outweigh the benefits of folic acid fortification, provided un-metabolized folic acid, RBC folate and vitamin B12 are monitored periodically. A European monitoring system, based on U.S. National Health and Nutrition Examination Surveys, should reside with the European Centre for Disease Prevention and Control." @default.
- W2803305487 created "2018-06-01" @default.
- W2803305487 creator A5003388574 @default.
- W2803305487 creator A5010489194 @default.
- W2803305487 creator A5048171680 @default.
- W2803305487 creator A5049749872 @default.
- W2803305487 date "2018-09-01" @default.
- W2803305487 modified "2023-10-16" @default.
- W2803305487 title "Folic acid and primary prevention of neural tube defects: A review" @default.
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