FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803314053> ?p ?o ?g. }

• W2803314053 abstract "Abstract One-step nucleic acid amplification (OSNA) is an established method for intraoperative diagnosis of breast cancer metastasis in sentinel lymph nodes, based on quantification of CK19 mRNA, specific to breast epithelial cells. Inhibitors interfere with the PCR amplification process of PCR. Thus, OSNA, based on gene amplification without RNA purification, might be impacted by numerous factors persisting in a sample, and thereby potentially acting as PCR inhibitors. However, neither the characteristics of breast cancers showing inhibitory effects during OSNA, nor any of the possible inhibitors, have as yet been identified. Inhibitory effects detected during OSNA in 72 metastatic lymph nodes and the patients’ clinicopathological features were examined. Left-over OSNA samples were analyzed with mass spectrometry to identify proteins possibly acting as inhibitors. Most tumors showed inhibitory effects, though to varying degrees. Large tumor, young age and high tumor-infiltrating lymphocyte counts were related to stronger inhibitory effects. Proteome analysis revealed elevations in RPB9 protein and EIF2 signaling upregulation in samples showing strong inhibitory effects. Tumors showing strong inhibitory effects had clinically relevant characteristics, including large size and extensive tumor-infiltrating lymphocyte involvement. Identifying inhibitors in OSNA might provide new insights into breast cancer biology as well as advancing the current technology." @default.
• W2803314053 created "2018-06-01" @default.
• W2803314053 creator A5012276632 @default.
• W2803314053 creator A5025267123 @default.
• W2803314053 creator A5025940379 @default.
• W2803314053 creator A5035374394 @default.
• W2803314053 creator A5036684310 @default.
• W2803314053 creator A5040976310 @default.
• W2803314053 creator A5069151475 @default.
• W2803314053 creator A5074134444 @default.
• W2803314053 creator A5087541425 @default.
• W2803314053 creator A5089768126 @default.
• W2803314053 date "2018-05-15" @default.
• W2803314053 modified "2023-10-18" @default.
• W2803314053 title "Elucidation of inhibitory effects on metastatic sentinel lymph nodes of breast cancer during One-Step Nucleic Acid Amplification" @default.
• W2803314053 cites W1487259648 @default.
• W2803314053 cites W1685023024 @default.
• W2803314053 cites W1973207608 @default.
• W2803314053 cites W2009191617 @default.
• W2803314053 cites W2044216826 @default.
• W2803314053 cites W2044454351 @default.
• W2803314053 cites W2047127733 @default.
• W2803314053 cites W2047289426 @default.
• W2803314053 cites W2054884958 @default.
• W2803314053 cites W2059354316 @default.
• W2803314053 cites W2065842063 @default.
• W2803314053 cites W2086451007 @default.
• W2803314053 cites W2088071966 @default.
• W2803314053 cites W2095989309 @default.
• W2803314053 cites W2105275554 @default.
• W2803314053 cites W2111956221 @default.
• W2803314053 cites W2115825530 @default.
• W2803314053 cites W2120431466 @default.
• W2803314053 cites W2146512944 @default.
• W2803314053 cites W2160376378 @default.
• W2803314053 cites W2738088519 @default.
• W2803314053 cites W2755363290 @default.
• W2803314053 doi "https://doi.org/10.1038/s41598-018-25911-w" @default.
• W2803314053 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5954024" @default.
• W2803314053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29765119" @default.
• W2803314053 hasPublicationYear "2018" @default.
• W2803314053 type Work @default.
• W2803314053 sameAs 2803314053 @default.
• W2803314053 citedByCount "2" @default.
• W2803314053 countsByYear W28033140532021 @default.
• W2803314053 countsByYear W28033140532022 @default.
• W2803314053 crossrefType "journal-article" @default.
• W2803314053 hasAuthorship W2803314053A5012276632 @default.
• W2803314053 hasAuthorship W2803314053A5025267123 @default.
• W2803314053 hasAuthorship W2803314053A5025940379 @default.
• W2803314053 hasAuthorship W2803314053A5035374394 @default.
• W2803314053 hasAuthorship W2803314053A5036684310 @default.
• W2803314053 hasAuthorship W2803314053A5040976310 @default.
• W2803314053 hasAuthorship W2803314053A5069151475 @default.
• W2803314053 hasAuthorship W2803314053A5074134444 @default.
• W2803314053 hasAuthorship W2803314053A5087541425 @default.
• W2803314053 hasAuthorship W2803314053A5089768126 @default.
• W2803314053 hasBestOaLocation W28033140531 @default.
• W2803314053 hasConcept C104317684 @default.
• W2803314053 hasConcept C104397665 @default.
• W2803314053 hasConcept C121608353 @default.
• W2803314053 hasConcept C126322002 @default.
• W2803314053 hasConcept C127561419 @default.
• W2803314053 hasConcept C142724271 @default.
• W2803314053 hasConcept C17077164 @default.
• W2803314053 hasConcept C24107716 @default.
• W2803314053 hasConcept C2779013556 @default.
• W2803314053 hasConcept C2779720271 @default.
• W2803314053 hasConcept C502942594 @default.
• W2803314053 hasConcept C530470458 @default.
• W2803314053 hasConcept C55493867 @default.
• W2803314053 hasConcept C60644358 @default.
• W2803314053 hasConcept C71924100 @default.
• W2803314053 hasConcept C86803240 @default.
• W2803314053 hasConceptScore W2803314053C104317684 @default.
• W2803314053 hasConceptScore W2803314053C104397665 @default.
• W2803314053 hasConceptScore W2803314053C121608353 @default.
• W2803314053 hasConceptScore W2803314053C126322002 @default.
• W2803314053 hasConceptScore W2803314053C127561419 @default.
• W2803314053 hasConceptScore W2803314053C142724271 @default.
• W2803314053 hasConceptScore W2803314053C17077164 @default.
• W2803314053 hasConceptScore W2803314053C24107716 @default.
• W2803314053 hasConceptScore W2803314053C2779013556 @default.
• W2803314053 hasConceptScore W2803314053C2779720271 @default.
• W2803314053 hasConceptScore W2803314053C502942594 @default.
• W2803314053 hasConceptScore W2803314053C530470458 @default.
• W2803314053 hasConceptScore W2803314053C55493867 @default.
• W2803314053 hasConceptScore W2803314053C60644358 @default.
• W2803314053 hasConceptScore W2803314053C71924100 @default.
• W2803314053 hasConceptScore W2803314053C86803240 @default.
• W2803314053 hasIssue "1" @default.
• W2803314053 hasLocation W28033140531 @default.
• W2803314053 hasLocation W28033140532 @default.
• W2803314053 hasLocation W28033140533 @default.
• W2803314053 hasLocation W28033140534 @default.
• W2803314053 hasLocation W28033140535 @default.
• W2803314053 hasOpenAccess W2803314053 @default.
• W2803314053 hasPrimaryLocation W28033140531 @default.
• W2803314053 hasRelatedWork W2054174996 @default.
• W2803314053 hasRelatedWork W2086968193 @default.

• next