Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803325246> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2803325246 endingPage "2923" @default.
- W2803325246 startingPage "2911" @default.
- W2803325246 abstract "miR-598 acts as a tumor suppressor in human gastric cancer by targeting IGF-1R Na Liu,1 Hua Yang,2 Hong Wang3 1Intensive Care Unit, Shandong Provincial Third Hospital, Shandong, China; 2Intensive Care Unit, Chiping County People’s Hospital, Shandong, China; 3Department of General Surgery, Shandong Provincial Third Hospital, Shandong, China Background: In recent years, the aberrant expression of miR-598 in tumorigenesis has been demonstrated, as well as the fact that the IGF-1R pathway is also involved in the development of human gastric cancer (GC). The present study aimed to investigate the molecular mechanisms underlying miR-598-regulated IGF-1R expression in human GC.Materials and methods: We analyzed the expression of miR-598 and IGF-1R in GC samples and cells, and evaluated the clinical significance of miR-598 and IGF-1R in GC patients. Furthermore, in vitro and in vivo assays were used to investigate the molecular mechanisms of miR-598 and IGF-1R.Results: miR-598 expression was frequently downregulated in GC tissues and cells, and significantly correlated with poor prognosis, vascular invasion, TNM stage, and lymph node metastases as well as IGF-1R expression. The overexpression of miR-598 obviously inhibited cell proliferation, migration, invasion, and induced cell cycle arrest in the G1/S phase, and increased the apoptosis of GC cells. The overexpression of miR-598 also significantly inhibited ERK1/2 and Akt phosphorylation level. In vivo assay validated the inhibitory effect of miR-598 on tumor growth. Further studies showed that miR-598 inhibited IGF-1R protein expression by directly targeting its 3´-UTR. Besides, over-expression of IGF-1R reversed the inhibitory effects of miR-598, while suppression of IGF-1R expression showed inverse effects. Conclusion: miR-598 suppresses GC cell proliferation, migration and invasion by directly targeting IGF-1R expression. Thus, miR-598 may be a useful target for GC patients. Keywords: miR-598, IGF-1R, gastric cancer, proliferation, migration, invasion suppressor" @default.
- W2803325246 created "2018-06-01" @default.
- W2803325246 creator A5012439374 @default.
- W2803325246 creator A5033020983 @default.
- W2803325246 creator A5045545412 @default.
- W2803325246 date "2018-05-01" @default.
- W2803325246 modified "2023-09-27" @default.
- W2803325246 title "miR-598 acts as a tumor suppressor in human gastric cancer by targeting IGF-1R" @default.
- W2803325246 cites W1965983806 @default.
- W2803325246 cites W2124018073 @default.
- W2803325246 cites W2129049675 @default.
- W2803325246 cites W2152317098 @default.
- W2803325246 cites W2524983779 @default.
- W2803325246 cites W2585026947 @default.
- W2803325246 cites W2728408249 @default.
- W2803325246 cites W2741953965 @default.
- W2803325246 cites W2742895647 @default.
- W2803325246 cites W2743116197 @default.
- W2803325246 cites W2743651269 @default.
- W2803325246 cites W2744405493 @default.
- W2803325246 cites W2748662256 @default.
- W2803325246 cites W2751911397 @default.
- W2803325246 cites W2753042008 @default.
- W2803325246 cites W2766076173 @default.
- W2803325246 cites W2767495500 @default.
- W2803325246 cites W2767784638 @default.
- W2803325246 cites W2770957382 @default.
- W2803325246 cites W2778071905 @default.
- W2803325246 cites W2779610575 @default.
- W2803325246 cites W2791968111 @default.
- W2803325246 cites W2912667178 @default.
- W2803325246 cites W2982679874 @default.
- W2803325246 doi "https://doi.org/10.2147/ott.s166597" @default.
- W2803325246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5961641" @default.
- W2803325246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29844688" @default.
- W2803325246 hasPublicationYear "2018" @default.
- W2803325246 type Work @default.
- W2803325246 sameAs 2803325246 @default.
- W2803325246 citedByCount "17" @default.
- W2803325246 countsByYear W28033252462019 @default.
- W2803325246 countsByYear W28033252462020 @default.
- W2803325246 countsByYear W28033252462021 @default.
- W2803325246 countsByYear W28033252462022 @default.
- W2803325246 countsByYear W28033252462023 @default.
- W2803325246 crossrefType "journal-article" @default.
- W2803325246 hasAuthorship W2803325246A5012439374 @default.
- W2803325246 hasAuthorship W2803325246A5033020983 @default.
- W2803325246 hasAuthorship W2803325246A5045545412 @default.
- W2803325246 hasBestOaLocation W28033252461 @default.
- W2803325246 hasConcept C121608353 @default.
- W2803325246 hasConcept C126322002 @default.
- W2803325246 hasConcept C179185449 @default.
- W2803325246 hasConcept C190283241 @default.
- W2803325246 hasConcept C29537977 @default.
- W2803325246 hasConcept C502942594 @default.
- W2803325246 hasConcept C54355233 @default.
- W2803325246 hasConcept C55493867 @default.
- W2803325246 hasConcept C555283112 @default.
- W2803325246 hasConcept C62112901 @default.
- W2803325246 hasConcept C71924100 @default.
- W2803325246 hasConcept C75217442 @default.
- W2803325246 hasConcept C86803240 @default.
- W2803325246 hasConceptScore W2803325246C121608353 @default.
- W2803325246 hasConceptScore W2803325246C126322002 @default.
- W2803325246 hasConceptScore W2803325246C179185449 @default.
- W2803325246 hasConceptScore W2803325246C190283241 @default.
- W2803325246 hasConceptScore W2803325246C29537977 @default.
- W2803325246 hasConceptScore W2803325246C502942594 @default.
- W2803325246 hasConceptScore W2803325246C54355233 @default.
- W2803325246 hasConceptScore W2803325246C55493867 @default.
- W2803325246 hasConceptScore W2803325246C555283112 @default.
- W2803325246 hasConceptScore W2803325246C62112901 @default.
- W2803325246 hasConceptScore W2803325246C71924100 @default.
- W2803325246 hasConceptScore W2803325246C75217442 @default.
- W2803325246 hasConceptScore W2803325246C86803240 @default.
- W2803325246 hasLocation W28033252461 @default.
- W2803325246 hasLocation W28033252462 @default.
- W2803325246 hasLocation W28033252463 @default.
- W2803325246 hasLocation W28033252464 @default.
- W2803325246 hasLocation W28033252465 @default.
- W2803325246 hasOpenAccess W2803325246 @default.
- W2803325246 hasPrimaryLocation W28033252461 @default.
- W2803325246 hasRelatedWork W1991394829 @default.
- W2803325246 hasRelatedWork W2350294409 @default.
- W2803325246 hasRelatedWork W2351136637 @default.
- W2803325246 hasRelatedWork W2376744432 @default.
- W2803325246 hasRelatedWork W2382230817 @default.
- W2803325246 hasRelatedWork W2394129978 @default.
- W2803325246 hasRelatedWork W3022642502 @default.
- W2803325246 hasRelatedWork W3031159451 @default.
- W2803325246 hasRelatedWork W3031579642 @default.
- W2803325246 hasRelatedWork W56583510 @default.
- W2803325246 hasVolume "Volume 11" @default.
- W2803325246 isParatext "false" @default.
- W2803325246 isRetracted "false" @default.
- W2803325246 magId "2803325246" @default.
- W2803325246 workType "article" @default.