FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803338329> ?p ?o ?g. }

• W2803338329 abstract "Trueperella pyogenes is a commensal and opportunistic pathogen that normally causes mastitis, liver abscesses and pneumonia of economically important livestock. To develop efficacious and potent vaccine against T. pyogenes, chimeric gene DNA vaccines were constructed and encapsulated in chitosan nanoparticles (pPCFN-CpG-CS-NPs).The pPCFN-CpG-CS-NPs consists of the plo, cbpA, fimA, and nanH gene of T. pyogenes and CpG ODN1826. It was produced with good morphology, high stability, a mean diameter of 93.58 nm, and a zeta potential of + 5.27 mV. Additionally, chitosan encapsulation was confirmed to protect the DNA plasmid from DNase I digestion. The immunofluorescence assay indicated that the four-chimeric gene could synchronously express in HEK293T cells and maintain good bioactivity. Compared to the mice immunized with the control plasmid, in vivo immunization showed that mice immunized with the pPCFN-CpG-CS-NPs had better immune responses, and release of the plasmid DNA was prolonged. Importantly, immunization with pPCFN-CpG-CS-NPs could significantly protect mice from highly virulent T. pyogenes TP7 infection.This study indicates that chitosan-DNA nanoparticles are potent immunization candidates against T. pyogenes infection and provides strategies for the further development of novel vaccines encapsulated in chitosan nanoparticles." @default.
• W2803338329 created "2018-06-01" @default.
• W2803338329 creator A5004347770 @default.
• W2803338329 creator A5005330674 @default.
• W2803338329 creator A5014556886 @default.
• W2803338329 creator A5017589286 @default.
• W2803338329 creator A5020499334 @default.
• W2803338329 creator A5024242005 @default.
• W2803338329 creator A5074492756 @default.
• W2803338329 date "2018-01-29" @default.
• W2803338329 modified "2023-10-18" @default.
• W2803338329 title "Chitosan-DNA nanoparticles enhanced the immunogenicity of multivalent DNA vaccination on mice against Trueperella pyogenes infection" @default.
• W2803338329 cites W105463312 @default.
• W2803338329 cites W1917892434 @default.
• W2803338329 cites W1977018877 @default.
• W2803338329 cites W1980047627 @default.
• W2803338329 cites W1984389788 @default.
• W2803338329 cites W1984792232 @default.
• W2803338329 cites W1988455299 @default.
• W2803338329 cites W1989804804 @default.
• W2803338329 cites W1991087184 @default.
• W2803338329 cites W1992022076 @default.
• W2803338329 cites W2010992031 @default.
• W2803338329 cites W2012778617 @default.
• W2803338329 cites W2013168158 @default.
• W2803338329 cites W2020719323 @default.
• W2803338329 cites W2023687860 @default.
• W2803338329 cites W2033530261 @default.
• W2803338329 cites W2037187942 @default.
• W2803338329 cites W2044945345 @default.
• W2803338329 cites W2054531793 @default.
• W2803338329 cites W2056933125 @default.
• W2803338329 cites W2079648669 @default.
• W2803338329 cites W2084118479 @default.
• W2803338329 cites W2085166735 @default.
• W2803338329 cites W2110573136 @default.
• W2803338329 cites W2111409165 @default.
• W2803338329 cites W2126686694 @default.
• W2803338329 cites W2127163054 @default.
• W2803338329 cites W2128182400 @default.
• W2803338329 cites W2128432942 @default.
• W2803338329 cites W2132286842 @default.
• W2803338329 cites W2133207525 @default.
• W2803338329 cites W2139668415 @default.
• W2803338329 cites W2143504935 @default.
• W2803338329 cites W2147477933 @default.
• W2803338329 cites W2149412525 @default.
• W2803338329 cites W2149984099 @default.
• W2803338329 cites W2150652968 @default.
• W2803338329 cites W2151966541 @default.
• W2803338329 cites W2157307099 @default.
• W2803338329 cites W2160397907 @default.
• W2803338329 cites W2162343763 @default.
• W2803338329 cites W2167028666 @default.
• W2803338329 cites W2171976853 @default.
• W2803338329 cites W2288338987 @default.
• W2803338329 cites W2292286849 @default.
• W2803338329 cites W2337632165 @default.
• W2803338329 cites W2347019618 @default.
• W2803338329 doi "https://doi.org/10.1186/s12951-018-0337-2" @default.
• W2803338329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5787914" @default.
• W2803338329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29378591" @default.
• W2803338329 hasPublicationYear "2018" @default.
• W2803338329 type Work @default.
• W2803338329 sameAs 2803338329 @default.
• W2803338329 citedByCount "41" @default.
• W2803338329 countsByYear W28033383292018 @default.
• W2803338329 countsByYear W28033383292019 @default.
• W2803338329 countsByYear W28033383292020 @default.
• W2803338329 countsByYear W28033383292021 @default.
• W2803338329 countsByYear W28033383292022 @default.
• W2803338329 countsByYear W28033383292023 @default.
• W2803338329 crossrefType "journal-article" @default.
• W2803338329 hasAuthorship W2803338329A5004347770 @default.
• W2803338329 hasAuthorship W2803338329A5005330674 @default.
• W2803338329 hasAuthorship W2803338329A5014556886 @default.
• W2803338329 hasAuthorship W2803338329A5017589286 @default.
• W2803338329 hasAuthorship W2803338329A5020499334 @default.
• W2803338329 hasAuthorship W2803338329A5024242005 @default.
• W2803338329 hasAuthorship W2803338329A5074492756 @default.
• W2803338329 hasBestOaLocation W28033383291 @default.
• W2803338329 hasConcept C104317684 @default.
• W2803338329 hasConcept C150194340 @default.
• W2803338329 hasConcept C159047783 @default.
• W2803338329 hasConcept C167508917 @default.
• W2803338329 hasConcept C185592680 @default.
• W2803338329 hasConcept C190727270 @default.
• W2803338329 hasConcept C203014093 @default.
• W2803338329 hasConcept C22070199 @default.
• W2803338329 hasConcept C22801619 @default.
• W2803338329 hasConcept C2777863537 @default.
• W2803338329 hasConcept C2779732960 @default.
• W2803338329 hasConcept C2780801004 @default.
• W2803338329 hasConcept C2780868878 @default.
• W2803338329 hasConcept C55493867 @default.
• W2803338329 hasConcept C86803240 @default.
• W2803338329 hasConcept C8891405 @default.
• W2803338329 hasConcept C89423630 @default.
• W2803338329 hasConceptScore W2803338329C104317684 @default.
• W2803338329 hasConceptScore W2803338329C150194340 @default.

• next