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- W2803340220 abstract "CRISPR/Cas9 pooled screening permits parallel evaluation of comprehensive guide RNA libraries to systematically perturb protein coding sequences in situ and correlate with functional readouts. For the analysis and visualization of the resulting datasets, we develop CRISPRO, a computational pipeline that maps functional scores associated with guide RNAs to genomes, transcripts, and protein coordinates and structures. No currently available tool has similar functionality. The ensuing genotype-phenotype linear and three-dimensional maps raise hypotheses about structure-function relationships at discrete protein regions. Machine learning based on CRISPRO features improves prediction of guide RNA efficacy. The CRISPRO tool is freely available at gitlab.com/bauerlab/crispro ." @default.
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- W2803340220 date "2018-10-19" @default.
- W2803340220 modified "2023-10-14" @default.
- W2803340220 title "CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis" @default.
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- W2803340220 doi "https://doi.org/10.1186/s13059-018-1563-5" @default.
- W2803340220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6195731" @default.
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