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• W2803357178 endingPage "195" @default.
• W2803357178 startingPage "186" @default.
• W2803357178 abstract "Hotspot mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant IDH proteins acquire a neomorphic enzyme activity to produce the putative oncometabolite D-2-hydroxyglutarate, which is thought to block cellular differentiation by competitively inhibiting α-ketoglutarate-dependent dioxygenases involved in histone and DNA demethylation. Small-molecule inhibitors of mutant IDH1 and IDH2 have been developed and are progressing through pre-clinical and clinical development. In this review, we provide an overview of mutant IDH-targeted therapy and discuss a number of important recent pre-clinical studies using models of IDH-mutant solid tumors." @default.
• W2803357178 created "2018-06-01" @default.
• W2803357178 creator A5003944261 @default.
• W2803357178 creator A5034933958 @default.
• W2803357178 creator A5088890711 @default.
• W2803357178 date "2018-08-01" @default.
• W2803357178 modified "2023-10-15" @default.
• W2803357178 title "Biological Role and Therapeutic Potential of IDH Mutations in Cancer" @default.
• W2803357178 cites W1812256879 @default.
• W2803357178 cites W1824539338 @default.
• W2803357178 cites W1964001245 @default.
• W2803357178 cites W1988756388 @default.
• W2803357178 cites W1988887928 @default.
• W2803357178 cites W1995675594 @default.
• W2803357178 cites W1996492681 @default.
• W2803357178 cites W2000846273 @default.
• W2803357178 cites W2007673878 @default.
• W2803357178 cites W2008777301 @default.
• W2803357178 cites W2011526905 @default.
• W2803357178 cites W2012588998 @default.
• W2803357178 cites W2013020286 @default.
• W2803357178 cites W2015755329 @default.
• W2803357178 cites W2023014046 @default.
• W2803357178 cites W2035409103 @default.
• W2803357178 cites W2039945243 @default.
• W2803357178 cites W2040827479 @default.
• W2803357178 cites W2043720679 @default.
• W2803357178 cites W2046849979 @default.
• W2803357178 cites W2047867594 @default.
• W2803357178 cites W2058562945 @default.
• W2803357178 cites W2058947771 @default.
• W2803357178 cites W2061122794 @default.
• W2803357178 cites W2067537818 @default.
• W2803357178 cites W2074448607 @default.
• W2803357178 cites W2078972833 @default.
• W2803357178 cites W2080452140 @default.
• W2803357178 cites W2085293170 @default.
• W2803357178 cites W2092527265 @default.
• W2803357178 cites W2094851085 @default.
• W2803357178 cites W2096796171 @default.
• W2803357178 cites W2105528101 @default.
• W2803357178 cites W2109378990 @default.
• W2803357178 cites W2111988427 @default.
• W2803357178 cites W2114064258 @default.
• W2803357178 cites W2116134519 @default.
• W2803357178 cites W2116562310 @default.
• W2803357178 cites W2117036448 @default.
• W2803357178 cites W2120566462 @default.
• W2803357178 cites W2126817554 @default.
• W2803357178 cites W2128083719 @default.
• W2803357178 cites W2131860315 @default.
• W2803357178 cites W2132555177 @default.
• W2803357178 cites W2134061682 @default.
• W2803357178 cites W2137361994 @default.
• W2803357178 cites W2138472595 @default.
• W2803357178 cites W2142898716 @default.
• W2803357178 cites W2152496375 @default.
• W2803357178 cites W2154313451 @default.
• W2803357178 cites W2158900087 @default.
• W2803357178 cites W2159842626 @default.
• W2803357178 cites W2164277652 @default.
• W2803357178 cites W2165307233 @default.
• W2803357178 cites W2166138133 @default.
• W2803357178 cites W2184483246 @default.
• W2803357178 cites W2192221936 @default.
• W2803357178 cites W2196531476 @default.
• W2803357178 cites W2346815884 @default.
• W2803357178 cites W2411032707 @default.
• W2803357178 cites W2411898462 @default.
• W2803357178 cites W2419775710 @default.
• W2803357178 cites W2475161005 @default.
• W2803357178 cites W2496785181 @default.
• W2803357178 cites W2520340383 @default.
• W2803357178 cites W2526865897 @default.
• W2803357178 cites W2530614832 @default.
• W2803357178 cites W2532104363 @default.
• W2803357178 cites W2537440061 @default.
• W2803357178 cites W2556519788 @default.
• W2803357178 cites W2582446241 @default.
• W2803357178 cites W2584285792 @default.
• W2803357178 cites W2585000600 @default.
• W2803357178 cites W2585230893 @default.
• W2803357178 cites W2588385654 @default.
• W2803357178 cites W2596261790 @default.
• W2803357178 cites W2611222875 @default.
• W2803357178 cites W2615603032 @default.
• W2803357178 cites W2623089849 @default.
• W2803357178 cites W2624245118 @default.
• W2803357178 cites W2625310957 @default.
• W2803357178 cites W2750794123 @default.
• W2803357178 cites W2755660258 @default.
• W2803357178 cites W2760885207 @default.
• W2803357178 cites W2765825833 @default.
• W2803357178 cites W2766297389 @default.
• W2803357178 cites W2766649068 @default.
• W2803357178 cites W2767704967 @default.
• W2803357178 cites W4238448376 @default.
• W2803357178 doi "https://doi.org/10.1016/j.ccell.2018.04.011" @default.

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