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- W2803376239 abstract "The production of veritable in-vitro models of bone tissue is essential to understand the biology of bone and its surrounding environment, to analyze the pathogenesis of bone diseases (e.g., osteoporosis, osteoarthritis, osteomyelitis, etc.), to develop effective therapeutic drug screening, and to test potential therapeutic strategies. Dysregulated interactions between vasculature and bone cells are often related to the aforementioned pathologies, underscoring the need for a bone model that contains engineered vasculature. Due to ethical restraints and limited prediction power of animal models, human stem cell-based tissue engineering has gained increasing relevance as a candidate approach to overcome the limitations of animals and to serve as preclinical models for drug testing. Since bone is a highly vascularized tissue, the concomitant development of vasculature and mineralized matrix requires a synergistic interaction between osteogenic and endothelial precursors. A number of experimental approaches have been used to achieve this goal, such as the combination of angiogenic factors and three-dimensional scaffolds, prevascularization strategies, and coculture systems. In this review, we present an overview of the current models and approaches to generate in-vitro stem cell-based vascularized bone, with emphasis on the main challenges of vasculature engineering. These challenges are related to the choice of biomaterials, scaffold fabrication techniques, and cells, as well as the type of culturing conditions required, and specifically the application of dynamic culture systems using bioreactors." @default.
- W2803376239 created "2018-06-01" @default.
- W2803376239 creator A5038295992 @default.
- W2803376239 creator A5050735414 @default.
- W2803376239 creator A5057499766 @default.
- W2803376239 creator A5083864939 @default.
- W2803376239 date "2018-04-20" @default.
- W2803376239 modified "2023-10-09" @default.
- W2803376239 title "Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology" @default.
- W2803376239 cites W1132096098 @default.
- W2803376239 cites W1482530281 @default.
- W2803376239 cites W1502960530 @default.
- W2803376239 cites W1504133802 @default.
- W2803376239 cites W151385306 @default.
- W2803376239 cites W1525037997 @default.
- W2803376239 cites W1528273659 @default.
- W2803376239 cites W1581509026 @default.
- W2803376239 cites W1606867770 @default.
- W2803376239 cites W1778992935 @default.
- W2803376239 cites W1783015899 @default.
- W2803376239 cites W1829163856 @default.
- W2803376239 cites W1844685923 @default.
- W2803376239 cites W1868158647 @default.
- W2803376239 cites W1890811286 @default.
- W2803376239 cites W1900466502 @default.
- W2803376239 cites W1911686885 @default.
- W2803376239 cites W1925689366 @default.
- W2803376239 cites W1948888524 @default.
- W2803376239 cites W1964383077 @default.
- W2803376239 cites W1964439844 @default.
- W2803376239 cites W1965299016 @default.
- W2803376239 cites W1965511151 @default.
- W2803376239 cites W1965535050 @default.
- W2803376239 cites W1969273272 @default.
- W2803376239 cites W1970224514 @default.
- W2803376239 cites W1970563277 @default.
- W2803376239 cites W1972628738 @default.
- W2803376239 cites W1973054754 @default.
- W2803376239 cites W1973626130 @default.
- W2803376239 cites W1974953332 @default.
- W2803376239 cites W1975254455 @default.
- W2803376239 cites W1976842528 @default.
- W2803376239 cites W1977611420 @default.
- W2803376239 cites W1978937938 @default.
- W2803376239 cites W1979139586 @default.
- W2803376239 cites W1979320290 @default.
- W2803376239 cites W1980751943 @default.
- W2803376239 cites W1980773309 @default.
- W2803376239 cites W1981030985 @default.
- W2803376239 cites W1983084875 @default.
- W2803376239 cites W1984758838 @default.
- W2803376239 cites W1984985208 @default.
- W2803376239 cites W1985301413 @default.
- W2803376239 cites W1985597509 @default.
- W2803376239 cites W1986247883 @default.
- W2803376239 cites W1986335724 @default.
- W2803376239 cites W1987254959 @default.
- W2803376239 cites W1987813151 @default.
- W2803376239 cites W1988553710 @default.
- W2803376239 cites W1991226167 @default.
- W2803376239 cites W1991891816 @default.
- W2803376239 cites W1991907993 @default.
- W2803376239 cites W1992284507 @default.
- W2803376239 cites W1993037781 @default.
- W2803376239 cites W1993765543 @default.
- W2803376239 cites W1996499787 @default.
- W2803376239 cites W1996626693 @default.
- W2803376239 cites W1998695273 @default.
- W2803376239 cites W1999589417 @default.
- W2803376239 cites W1999761575 @default.
- W2803376239 cites W1999928739 @default.
- W2803376239 cites W2000292756 @default.
- W2803376239 cites W2000398434 @default.
- W2803376239 cites W2000896602 @default.
- W2803376239 cites W2001534912 @default.
- W2803376239 cites W2002187143 @default.
- W2803376239 cites W2002702688 @default.
- W2803376239 cites W2003757462 @default.
- W2803376239 cites W2005424476 @default.
- W2803376239 cites W2005582543 @default.
- W2803376239 cites W2007055685 @default.
- W2803376239 cites W2007310752 @default.
- W2803376239 cites W2007438347 @default.
- W2803376239 cites W2007496674 @default.
- W2803376239 cites W2008565536 @default.
- W2803376239 cites W2009035128 @default.
- W2803376239 cites W2009251691 @default.
- W2803376239 cites W2010061535 @default.
- W2803376239 cites W2010343663 @default.
- W2803376239 cites W2010359869 @default.
- W2803376239 cites W2010361875 @default.
- W2803376239 cites W2011339778 @default.
- W2803376239 cites W2013054641 @default.
- W2803376239 cites W2014673628 @default.
- W2803376239 cites W2015905988 @default.
- W2803376239 cites W2017101002 @default.
- W2803376239 cites W2017394391 @default.
- W2803376239 cites W2017545194 @default.
- W2803376239 cites W2021513676 @default.
- W2803376239 cites W2022056770 @default.