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- W2803376356 abstract "The Receptor-interacting protein kinase Homotypic Interaction Motif (RHIM) is an amino acid sequence that mediates multiple protein:protein interactions in the mammalian programmed cell death pathway known as necroptosis. At least one key RHIM-based complex has been shown to have a functional amyloid fibril structure, which provides a stable hetero-oligomeric platform for downstream signaling. RHIMs and related motifs are present in immunity-related proteins across nature, from viruses to fungi to metazoans. Necroptosis is a hallmark feature of cellular clearance of infection. For this reason, numerous pathogens, including viruses and bacteria, have developed varied methods to modulate necroptosis, focusing on inhibiting RHIM:RHIM interactions, and thus their downstream cell death effects. This review will discuss current understanding of RHIM:RHIM interactions in normal cellular activation of necroptosis, from a structural and cell biology perspective. It will compare the mechanisms by which pathogens subvert these interactions in order to maintain their replicative and infective cycles and consider the similarities between RHIMs and other functional amyloid-forming proteins associated with cell death and innate immunity. It will discuss the implications of the heteromeric nature and structure of RHIM-based amyloid complexes in the context of other functional amyloids." @default.
- W2803376356 created "2018-06-01" @default.
- W2803376356 creator A5017915370 @default.
- W2803376356 creator A5023409866 @default.
- W2803376356 creator A5026985599 @default.
- W2803376356 creator A5056963916 @default.
- W2803376356 creator A5069471716 @default.
- W2803376356 creator A5079596222 @default.
- W2803376356 date "2020-03-01" @default.
- W2803376356 modified "2023-10-01" @default.
- W2803376356 title "RHIM-based protein:protein interactions in microbial defence against programmed cell death by necroptosis" @default.
- W2803376356 cites W1489708565 @default.
- W2803376356 cites W1548775239 @default.
- W2803376356 cites W1847069914 @default.
- W2803376356 cites W1850224498 @default.
- W2803376356 cites W1928433221 @default.
- W2803376356 cites W1941515972 @default.
- W2803376356 cites W1969087061 @default.
- W2803376356 cites W1969899825 @default.
- W2803376356 cites W1970462135 @default.
- W2803376356 cites W1973615540 @default.
- W2803376356 cites W1976081960 @default.
- W2803376356 cites W1976201852 @default.
- W2803376356 cites W1977099212 @default.
- W2803376356 cites W1980439269 @default.
- W2803376356 cites W1983151602 @default.
- W2803376356 cites W1985231277 @default.
- W2803376356 cites W1986283558 @default.
- W2803376356 cites W1986978728 @default.
- W2803376356 cites W1987186266 @default.
- W2803376356 cites W1993613360 @default.
- W2803376356 cites W1993823146 @default.
- W2803376356 cites W1994662708 @default.
- W2803376356 cites W1998983498 @default.
- W2803376356 cites W2002507218 @default.
- W2803376356 cites W2005572311 @default.
- W2803376356 cites W2008757142 @default.
- W2803376356 cites W2009414050 @default.
- W2803376356 cites W2009958847 @default.
- W2803376356 cites W2011698659 @default.
- W2803376356 cites W2014795321 @default.
- W2803376356 cites W2017317217 @default.
- W2803376356 cites W2028792773 @default.
- W2803376356 cites W2031208709 @default.
- W2803376356 cites W2034006241 @default.
- W2803376356 cites W2038401000 @default.
- W2803376356 cites W2038482759 @default.
- W2803376356 cites W2044985510 @default.
- W2803376356 cites W2045991166 @default.
- W2803376356 cites W2046093999 @default.
- W2803376356 cites W2051026238 @default.
- W2803376356 cites W2058824573 @default.
- W2803376356 cites W2062835892 @default.
- W2803376356 cites W2064434771 @default.
- W2803376356 cites W2071769633 @default.
- W2803376356 cites W2072179322 @default.
- W2803376356 cites W2074931193 @default.
- W2803376356 cites W2076361525 @default.
- W2803376356 cites W2076658768 @default.
- W2803376356 cites W2077490715 @default.
- W2803376356 cites W2078850432 @default.
- W2803376356 cites W2084414744 @default.
- W2803376356 cites W2088032380 @default.
- W2803376356 cites W2091263717 @default.
- W2803376356 cites W2091802222 @default.
- W2803376356 cites W2093498058 @default.
- W2803376356 cites W2094356159 @default.
- W2803376356 cites W2096939298 @default.
- W2803376356 cites W2108367007 @default.
- W2803376356 cites W2112256325 @default.
- W2803376356 cites W2116428280 @default.
- W2803376356 cites W2118038164 @default.
- W2803376356 cites W2122466812 @default.
- W2803376356 cites W2132025920 @default.
- W2803376356 cites W2132161879 @default.
- W2803376356 cites W2138355969 @default.
- W2803376356 cites W2141738274 @default.
- W2803376356 cites W2142794903 @default.
- W2803376356 cites W2144356753 @default.
- W2803376356 cites W2145165064 @default.
- W2803376356 cites W2150281085 @default.
- W2803376356 cites W2154928488 @default.
- W2803376356 cites W2165186407 @default.
- W2803376356 cites W2169238760 @default.
- W2803376356 cites W2265728551 @default.
- W2803376356 cites W2287080039 @default.
- W2803376356 cites W2328275151 @default.
- W2803376356 cites W2346310044 @default.
- W2803376356 cites W2396676392 @default.
- W2803376356 cites W2547118804 @default.
- W2803376356 cites W2547911415 @default.
- W2803376356 cites W2557727092 @default.
- W2803376356 cites W2573286366 @default.
- W2803376356 cites W2622955470 @default.
- W2803376356 cites W2736148366 @default.
- W2803376356 cites W2765943536 @default.
- W2803376356 cites W2773003990 @default.
- W2803376356 cites W2802914881 @default.