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- W2803381566 abstract "Protein-coding genes expressed in sperm evolve at different rates. To gain deeper insight into the factors underlying this heterogeneity we examined the relative importance of a diverse set of previously described rate correlates in determining the evolution of murine sperm proteins.Using partial rank correlations we detected several major rate indicators: Phyletic gene age, numbers of protein-protein interactions, and survival essentiality emerged as particularly important rate correlates in murine sperm proteins. Tissue specificity, numbers of paralogs, and untranslated region lengths also correlate significantly with sperm genes' evolutionary rates, albeit to a lesser extent. Multifunctionality, coding sequence or average intron lengths, and mean expression level have insignificant or virtually no independent effects on evolutionary rates in murine sperm genes. Gene ontology enrichment analyses of three equally sized murine sperm protein groups classified based on their evolutionary rates indicate strongest sperm-specific functional specialization in the most quickly evolving gene class.We propose a model according to which slowly evolving murine sperm proteins tend to be constrained by factors such as survival essentiality, network connectivity, and/or broad expression. In contrast, evolutionary change may arise especially in less constrained sperm proteins, which might, moreover, be prone to specialize to reproduction-related functions. Our results should be taken into account in future studies on rate variations of reproductive genes." @default.
- W2803381566 created "2018-06-01" @default.
- W2803381566 creator A5011246758 @default.
- W2803381566 creator A5020502269 @default.
- W2803381566 date "2018-03-27" @default.
- W2803381566 modified "2023-10-01" @default.
- W2803381566 title "Correlates of evolutionary rates in the murine sperm proteome" @default.
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- W2803381566 doi "https://doi.org/10.1186/s12862-018-1157-6" @default.
- W2803381566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5870804" @default.
- W2803381566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29580206" @default.
- W2803381566 hasPublicationYear "2018" @default.
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