FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803394252> ?p ?o ?g. }

• W2803394252 abstract "ABSTRACT Natural competence allows bacteria to respond to environmental and nutritional cues by taking up free DNA from their surroundings, thus gaining nutrients and genetic information. In the Gram-negative bacterium Haemophilus influenae , the DNA uptake machinery is induced by the CRP and Sxy transcription factors in response to lack of preferred carbon sources and nucleotide precursors. Here we show that HI0659 —which is absolutely required for DNA uptake— encodes the antitoxin of a competence-regulated toxin-antitoxin operon (‘ toxTA’ ), likely acquired by horizontal gene transfer from a Streptococcus species. Deletion of the toxin restores uptake to the antitoxin mutant. In addition to the expected Sxy-and CRP-dependent-competence promoter, transcript analysis using RNA-seq identified an internal antitoxin-repressed promoter whose transcription starts within toxT and will yield nonfunctional protein. We present evidence that the most likely effect of unopposed toxin expression is non-specific cleavage of mRNAs and arrest or death of competent cells in the culture, and we show that the toxin gene has been inactivated by deletion in many H. influenzae strains. We suggest that this competence-regulated toxin-antitoxin system may facilitate downregulation of protein synthesis and recycling of nucleotides under starvation conditions, or alternatively be a simple genetic parasite." @default.
• W2803394252 created "2018-06-01" @default.
• W2803394252 creator A5005325270 @default.
• W2803394252 creator A5015367083 @default.
• W2803394252 creator A5021602288 @default.
• W2803394252 creator A5058264470 @default.
• W2803394252 creator A5069396293 @default.
• W2803394252 creator A5075013024 @default.
• W2803394252 creator A5081059282 @default.
• W2803394252 date "2018-05-25" @default.
• W2803394252 modified "2023-09-24" @default.
• W2803394252 title "A competence-regulated toxin-antitoxin system in Haemophilus influenzae" @default.
• W2803394252 cites W1443898972 @default.
• W2803394252 cites W1520257721 @default.
• W2803394252 cites W1549108890 @default.
• W2803394252 cites W1830177261 @default.
• W2803394252 cites W1964943709 @default.
• W2803394252 cites W1971787896 @default.
• W2803394252 cites W1974735876 @default.
• W2803394252 cites W1975182786 @default.
• W2803394252 cites W1983770726 @default.
• W2803394252 cites W1985934885 @default.
• W2803394252 cites W1988753673 @default.
• W2803394252 cites W2001494166 @default.
• W2803394252 cites W2003439190 @default.
• W2803394252 cites W2015318086 @default.
• W2803394252 cites W2017433972 @default.
• W2803394252 cites W2034302623 @default.
• W2803394252 cites W2041699785 @default.
• W2803394252 cites W2085401806 @default.
• W2803394252 cites W2096093282 @default.
• W2803394252 cites W2096365000 @default.
• W2803394252 cites W2098039761 @default.
• W2803394252 cites W2102976471 @default.
• W2803394252 cites W2108141290 @default.
• W2803394252 cites W2112295728 @default.
• W2803394252 cites W2122492159 @default.
• W2803394252 cites W2122673596 @default.
• W2803394252 cites W2124967403 @default.
• W2803394252 cites W2126573196 @default.
• W2803394252 cites W2126622794 @default.
• W2803394252 cites W2127779871 @default.
• W2803394252 cites W2132417094 @default.
• W2803394252 cites W2137444535 @default.
• W2803394252 cites W2141052558 @default.
• W2803394252 cites W2142654521 @default.
• W2803394252 cites W2158992333 @default.
• W2803394252 cites W2159001707 @default.
• W2803394252 cites W2159105099 @default.
• W2803394252 cites W2160378127 @default.
• W2803394252 cites W2169235657 @default.
• W2803394252 cites W2243973145 @default.
• W2803394252 cites W2298249827 @default.
• W2803394252 cites W2519431925 @default.
• W2803394252 cites W2600605767 @default.
• W2803394252 cites W4236236547 @default.
• W2803394252 doi "https://doi.org/10.1101/330480" @default.
• W2803394252 hasPublicationYear "2018" @default.
• W2803394252 type Work @default.
• W2803394252 sameAs 2803394252 @default.
• W2803394252 citedByCount "0" @default.
• W2803394252 crossrefType "posted-content" @default.
• W2803394252 hasAuthorship W2803394252A5005325270 @default.
• W2803394252 hasAuthorship W2803394252A5015367083 @default.
• W2803394252 hasAuthorship W2803394252A5021602288 @default.
• W2803394252 hasAuthorship W2803394252A5058264470 @default.
• W2803394252 hasAuthorship W2803394252A5069396293 @default.
• W2803394252 hasAuthorship W2803394252A5075013024 @default.
• W2803394252 hasAuthorship W2803394252A5081059282 @default.
• W2803394252 hasBestOaLocation W28033942521 @default.
• W2803394252 hasConcept C104317684 @default.
• W2803394252 hasConcept C138885662 @default.
• W2803394252 hasConcept C143065580 @default.
• W2803394252 hasConcept C179926584 @default.
• W2803394252 hasConcept C203075996 @default.
• W2803394252 hasConcept C2777367657 @default.
• W2803394252 hasConcept C2778973234 @default.
• W2803394252 hasConcept C41895202 @default.
• W2803394252 hasConcept C523546767 @default.
• W2803394252 hasConcept C54355233 @default.
• W2803394252 hasConcept C552990157 @default.
• W2803394252 hasConcept C86803240 @default.
• W2803394252 hasConcept C89423630 @default.
• W2803394252 hasConcept C95444343 @default.
• W2803394252 hasConceptScore W2803394252C104317684 @default.
• W2803394252 hasConceptScore W2803394252C138885662 @default.
• W2803394252 hasConceptScore W2803394252C143065580 @default.
• W2803394252 hasConceptScore W2803394252C179926584 @default.
• W2803394252 hasConceptScore W2803394252C203075996 @default.
• W2803394252 hasConceptScore W2803394252C2777367657 @default.
• W2803394252 hasConceptScore W2803394252C2778973234 @default.
• W2803394252 hasConceptScore W2803394252C41895202 @default.
• W2803394252 hasConceptScore W2803394252C523546767 @default.
• W2803394252 hasConceptScore W2803394252C54355233 @default.
• W2803394252 hasConceptScore W2803394252C552990157 @default.
• W2803394252 hasConceptScore W2803394252C86803240 @default.
• W2803394252 hasConceptScore W2803394252C89423630 @default.
• W2803394252 hasConceptScore W2803394252C95444343 @default.
• W2803394252 hasLocation W28033942521 @default.
• W2803394252 hasLocation W28033942522 @default.

• next