FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803399666> ?p ?o ?g. }

• W2803399666 endingPage "18" @default.
• W2803399666 startingPage "7" @default.
• W2803399666 abstract "Numerous modern basic research done undeniable fact that neutrophilic granulocytes (NG) are key effector and regulatory circuits both innate and adaptive immunity, and play a crucial role in the pathogenesis of a wide range of diseases. NG have potent receptor repertoire, providing a connection between them, cells of the immune system, as well as communication with endothelial cells, epithelial and other tissues. NG inducing stimuli activate and promote the translocation of cytoplasmic granules and vesicles surface molecules on the cytoplasmic membrane the secretion of a large spectrum of pro-and anti-inflammatory, immunoregulatory cytokines, colony, angiogenic factors and fibrogenic, TNF superfamily members, chemokines, regulatory protein, etc. Chromatin nuclei NG capable of restructuring under the influence of inducing stimuli, which is associated with the expression of multiple cytokine genes. NG receiving complex cytokine influence not only acquire new features, but also in various stages of activation and differentiation processes involved in intracellular intraphagosomalis degranulation and killing of implementing elimination microorganisms and extracellular neutrophil degranulation in the formation neutrophil extracellular traps (NET), while this dying through NETosis. Features NG phenotype and their functional properties, demonstrate the existence of subpopulations of NG with different capabilities: equipment of different receptor, the ability to restructure chromatin expressing cytokine genes and secrete cytokines to implement the contents of the granular system, produce reactive oxygen species, implement cytotoxicity form NET. In our opinion, there subpopulation NG: regulatory; suppressor; proinflammatory — initiating an inflammatory response; inflammation with a positive potential microbicidal (antibacterial, antiviral, antifungal); inflammatory cytotoxic potential of the negative — «aggressive»; anti-inflammation regulating regression; antitumoral — TAN1; pro-tumoral — TAN2; hybrid, combining the characteristics of NG and dendritic cells. The absence of adequate response, or hyperactivation blockade NG functions leads to the development of low-intensity infectious and inflammatory diseases, do not respond to conventional therapy of autoimmune diseases/chronic immune-dependent processes. Remo deling dysfunctions NG — the key to new immunotherapeutic strategies." @default.
• W2803399666 created "2018-06-01" @default.
• W2803399666 creator A5017985589 @default.
• W2803399666 creator A5022233197 @default.
• W2803399666 creator A5027669058 @default.
• W2803399666 creator A5039650446 @default.
• W2803399666 creator A5042473311 @default.
• W2803399666 creator A5070574731 @default.
• W2803399666 creator A5084041034 @default.
• W2803399666 date "2018-05-17" @default.
• W2803399666 modified "2023-10-02" @default.
• W2803399666 title "THE NEW LOOK AT NEUTROPHILIC GRANULOCYTES: RETHINKING OLD DOGMAS. PART 2" @default.
• W2803399666 cites W1493775316 @default.
• W2803399666 cites W1557337012 @default.
• W2803399666 cites W1970766316 @default.
• W2803399666 cites W1979790110 @default.
• W2803399666 cites W1980734840 @default.
• W2803399666 cites W1984747276 @default.
• W2803399666 cites W1986953583 @default.
• W2803399666 cites W1989111278 @default.
• W2803399666 cites W2002157461 @default.
• W2803399666 cites W2010942909 @default.
• W2803399666 cites W2012949052 @default.
• W2803399666 cites W2017040416 @default.
• W2803399666 cites W2019047698 @default.
• W2803399666 cites W2036965973 @default.
• W2803399666 cites W2066068520 @default.
• W2803399666 cites W2088067478 @default.
• W2803399666 cites W2092729983 @default.
• W2803399666 cites W2111688818 @default.
• W2803399666 cites W2125123324 @default.
• W2803399666 cites W2125894404 @default.
• W2803399666 cites W2126355151 @default.
• W2803399666 cites W2136108844 @default.
• W2803399666 cites W2138694950 @default.
• W2803399666 cites W2147286476 @default.
• W2803399666 cites W2152221103 @default.
• W2803399666 cites W2308695447 @default.
• W2803399666 cites W2405920214 @default.
• W2803399666 cites W2574678992 @default.
• W2803399666 doi "https://doi.org/10.15789/2220-7619-2018-1-7-18" @default.
• W2803399666 hasPublicationYear "2018" @default.
• W2803399666 type Work @default.
• W2803399666 sameAs 2803399666 @default.
• W2803399666 citedByCount "9" @default.
• W2803399666 countsByYear W28033996662018 @default.
• W2803399666 countsByYear W28033996662020 @default.
• W2803399666 countsByYear W28033996662021 @default.
• W2803399666 countsByYear W28033996662022 @default.
• W2803399666 crossrefType "journal-article" @default.
• W2803399666 hasAuthorship W2803399666A5017985589 @default.
• W2803399666 hasAuthorship W2803399666A5022233197 @default.
• W2803399666 hasAuthorship W2803399666A5027669058 @default.
• W2803399666 hasAuthorship W2803399666A5039650446 @default.
• W2803399666 hasAuthorship W2803399666A5042473311 @default.
• W2803399666 hasAuthorship W2803399666A5070574731 @default.
• W2803399666 hasAuthorship W2803399666A5084041034 @default.
• W2803399666 hasBestOaLocation W28033996661 @default.
• W2803399666 hasConcept C104317684 @default.
• W2803399666 hasConcept C13373296 @default.
• W2803399666 hasConcept C134897094 @default.
• W2803399666 hasConcept C136449434 @default.
• W2803399666 hasConcept C154317977 @default.
• W2803399666 hasConcept C164027704 @default.
• W2803399666 hasConcept C170493617 @default.
• W2803399666 hasConcept C193419808 @default.
• W2803399666 hasConcept C202751555 @default.
• W2803399666 hasConcept C203014093 @default.
• W2803399666 hasConcept C2776914184 @default.
• W2803399666 hasConcept C2778690821 @default.
• W2803399666 hasConcept C49039625 @default.
• W2803399666 hasConcept C49802076 @default.
• W2803399666 hasConcept C51785407 @default.
• W2803399666 hasConcept C54355233 @default.
• W2803399666 hasConcept C55493867 @default.
• W2803399666 hasConcept C83640560 @default.
• W2803399666 hasConcept C86803240 @default.
• W2803399666 hasConcept C8891405 @default.
• W2803399666 hasConcept C95444343 @default.
• W2803399666 hasConceptScore W2803399666C104317684 @default.
• W2803399666 hasConceptScore W2803399666C13373296 @default.
• W2803399666 hasConceptScore W2803399666C134897094 @default.
• W2803399666 hasConceptScore W2803399666C136449434 @default.
• W2803399666 hasConceptScore W2803399666C154317977 @default.
• W2803399666 hasConceptScore W2803399666C164027704 @default.
• W2803399666 hasConceptScore W2803399666C170493617 @default.
• W2803399666 hasConceptScore W2803399666C193419808 @default.
• W2803399666 hasConceptScore W2803399666C202751555 @default.
• W2803399666 hasConceptScore W2803399666C203014093 @default.
• W2803399666 hasConceptScore W2803399666C2776914184 @default.
• W2803399666 hasConceptScore W2803399666C2778690821 @default.
• W2803399666 hasConceptScore W2803399666C49039625 @default.
• W2803399666 hasConceptScore W2803399666C49802076 @default.
• W2803399666 hasConceptScore W2803399666C51785407 @default.
• W2803399666 hasConceptScore W2803399666C54355233 @default.
• W2803399666 hasConceptScore W2803399666C55493867 @default.
• W2803399666 hasConceptScore W2803399666C83640560 @default.
• W2803399666 hasConceptScore W2803399666C86803240 @default.

• next