FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803413466> ?p ?o ?g. }

• W2803413466 endingPage "1435" @default.
• W2803413466 startingPage "1428" @default.
• W2803413466 abstract "Background Diuretic treatment is the mainstay for management of congestive heart failure in horses, and its use has been restricted to injectable medications because no currently data supports the use of PO administered loop diuretics. Objectives To determine the pharmacokinetic and pharmacodynamic properties of PO administered torsemide and, determine if PO administered torsemide, could be used as an alternative to injectable diuretics in the horse. Animals Six healthy adult mares. Methods A 2-phase, prospective study, that consisted of pharmacokinetic profiling of a single dose (6 mg/kg PO) and pharmacodynamic effects of long-term torsemide administration (2 mg/kg PO q12h) for 6 days in healthy horses. Results Pharmacokinetic analysis identified a peak concentration (Cmax) of 10.14 µg/mL (range, 6.79–14.69 µg/mL) and elimination half-life (T1/2) 9.2 hours (range, 8.4–10.4 hours). The area under the plasma drug concentration over time curve (AUC) was 80.7 µg × h/mL (range, 56.5–117.2 µg × h/mL). A statistically significant increase in urine volume and decrease in urine specific gravity were found from day 0 (baseline) to day 6 (P < .0001). Significant alterations in biochemical variables included hyponatremia, hypokalemia, hypochloremia, and increased serum creatinine concentration. Mean arterial blood pressure significantly decreased on day 6 (57.7 ± 8.8 mm Hg, P = .001) as compared with baseline (78 ± 6.1 mm Hg). Serum aldosterone concentrations significantly increased after 6 days of torsemide administration (P = .0006). Conclusions and Clinical Importance PO administered torsemide (4 mg/kg/day) successfully reached therapeutic concentrations in blood, induced clinically relevant diuresis, and resulted in moderate pre-renal azotemia and electrolyte disturbances." @default.
• W2803413466 created "2018-06-01" @default.
• W2803413466 creator A5028812716 @default.
• W2803413466 creator A5050181200 @default.
• W2803413466 creator A5062364054 @default.
• W2803413466 creator A5066572816 @default.
• W2803413466 creator A5072480165 @default.
• W2803413466 creator A5076054401 @default.
• W2803413466 date "2018-05-17" @default.
• W2803413466 modified "2023-09-23" @default.
• W2803413466 title "Pharmacokinetic and pharmacodynamic properties of orally administered torsemide in healthy horses" @default.
• W2803413466 cites W1484750057 @default.
• W2803413466 cites W1548090064 @default.
• W2803413466 cites W1599771798 @default.
• W2803413466 cites W1852552079 @default.
• W2803413466 cites W1968576264 @default.
• W2803413466 cites W1970675020 @default.
• W2803413466 cites W1978882295 @default.
• W2803413466 cites W1984909365 @default.
• W2803413466 cites W1992857605 @default.
• W2803413466 cites W2003238231 @default.
• W2803413466 cites W2015054945 @default.
• W2803413466 cites W2017220337 @default.
• W2803413466 cites W2018603271 @default.
• W2803413466 cites W2019830470 @default.
• W2803413466 cites W2025169561 @default.
• W2803413466 cites W2025717721 @default.
• W2803413466 cites W2028338937 @default.
• W2803413466 cites W2041877337 @default.
• W2803413466 cites W2044997338 @default.
• W2803413466 cites W2046071402 @default.
• W2803413466 cites W2047234939 @default.
• W2803413466 cites W2065350647 @default.
• W2803413466 cites W2076655202 @default.
• W2803413466 cites W2079691477 @default.
• W2803413466 cites W2086793695 @default.
• W2803413466 cites W2091872000 @default.
• W2803413466 cites W2133353561 @default.
• W2803413466 cites W2144011663 @default.
• W2803413466 cites W2158559891 @default.
• W2803413466 cites W2171986914 @default.
• W2803413466 cites W2285649618 @default.
• W2803413466 cites W2313484929 @default.
• W2803413466 cites W2407361089 @default.
• W2803413466 cites W2599978118 @default.
• W2803413466 cites W4238008463 @default.
• W2803413466 cites W4240026494 @default.
• W2803413466 cites W4245085815 @default.
• W2803413466 doi "https://doi.org/10.1111/jvim.15213" @default.
• W2803413466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6060311" @default.
• W2803413466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29770976" @default.
• W2803413466 hasPublicationYear "2018" @default.
• W2803413466 type Work @default.
• W2803413466 sameAs 2803413466 @default.
• W2803413466 citedByCount "1" @default.
• W2803413466 countsByYear W28034134662020 @default.
• W2803413466 crossrefType "journal-article" @default.
• W2803413466 hasAuthorship W2803413466A5028812716 @default.
• W2803413466 hasAuthorship W2803413466A5050181200 @default.
• W2803413466 hasAuthorship W2803413466A5062364054 @default.
• W2803413466 hasAuthorship W2803413466A5066572816 @default.
• W2803413466 hasAuthorship W2803413466A5072480165 @default.
• W2803413466 hasAuthorship W2803413466A5076054401 @default.
• W2803413466 hasBestOaLocation W28034134661 @default.
• W2803413466 hasConcept C111113717 @default.
• W2803413466 hasConcept C112705442 @default.
• W2803413466 hasConcept C126322002 @default.
• W2803413466 hasConcept C22979827 @default.
• W2803413466 hasConcept C2777462456 @default.
• W2803413466 hasConcept C2777955127 @default.
• W2803413466 hasConcept C2778242168 @default.
• W2803413466 hasConcept C2779918671 @default.
• W2803413466 hasConcept C71924100 @default.
• W2803413466 hasConcept C98274493 @default.
• W2803413466 hasConceptScore W2803413466C111113717 @default.
• W2803413466 hasConceptScore W2803413466C112705442 @default.
• W2803413466 hasConceptScore W2803413466C126322002 @default.
• W2803413466 hasConceptScore W2803413466C22979827 @default.
• W2803413466 hasConceptScore W2803413466C2777462456 @default.
• W2803413466 hasConceptScore W2803413466C2777955127 @default.
• W2803413466 hasConceptScore W2803413466C2778242168 @default.
• W2803413466 hasConceptScore W2803413466C2779918671 @default.
• W2803413466 hasConceptScore W2803413466C71924100 @default.
• W2803413466 hasConceptScore W2803413466C98274493 @default.
• W2803413466 hasIssue "4" @default.
• W2803413466 hasLocation W28034134661 @default.
• W2803413466 hasLocation W28034134662 @default.
• W2803413466 hasLocation W28034134663 @default.
• W2803413466 hasOpenAccess W2803413466 @default.
• W2803413466 hasPrimaryLocation W28034134661 @default.
• W2803413466 hasRelatedWork W1997101420 @default.
• W2803413466 hasRelatedWork W2070170242 @default.
• W2803413466 hasRelatedWork W2074499292 @default.
• W2803413466 hasRelatedWork W2158380752 @default.
• W2803413466 hasRelatedWork W2324881136 @default.
• W2803413466 hasRelatedWork W2371272957 @default.
• W2803413466 hasRelatedWork W2477866235 @default.
• W2803413466 hasRelatedWork W2803413466 @default.

• next