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- W2803414199 abstract "The purpose of the present study was to investigate whether ɑ-tocopherol exhibited neuro-protective effects in chronic unpredictable mild stress (CUMS) mice through the regulation of autophagy. Deficits in behavioural tests, including a sucrose preference test, open field test, forced swim test, and tail suspension test, were ameliorated following ɑ-tocopherol administration. To study the potential mechanism, western blots were performed on both prefrontal cortex and hippocampus samples. Similar to the degree of autophagy, the activities of adenosine monophosphate-activated protein kinase (AMPK) and Unci-51 like autophagy activating kinase-1 (ULK1) were decreased after CUMS stimulation. In addition, we also found increased activity of the mammalian target of rapamycin (mTOR), which was significantly affected following administration of ɑ-tocopherol, as well as its three downstream pathways. Taken together, our study found that ɑ-tocopherol might potentially promote autophagy to induce anti-depressive responses in CUMS mice though the AMPK/mTOR pathway." @default.
- W2803414199 created "2018-06-01" @default.
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- W2803414199 date "2018-08-01" @default.
- W2803414199 modified "2023-09-24" @default.
- W2803414199 title "The antidepressant effects of ɑ-tocopherol are related to activation of autophagy via the AMPK/mTOR pathway" @default.
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- W2803414199 doi "https://doi.org/10.1016/j.ejphar.2018.05.020" @default.
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