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- W2803457126 abstract "Abstract Lomaiviticin A and difluostatin A are benzofluorene-containing aromatic polyketides in the atypical angucycline family. Although these dimeric compounds are potent antitumor agents, how nature constructs their complex structures remains poorly understood. Herein, we report the discovery of a number of fluostatin type dimeric aromatic polyketides with varied C−C and C−N coupling patterns. We also demonstrate that these dimers are not true secondary metabolites, but are instead derived from non-enzymatic deacylation of biosynthetic acyl fluostatins. The non-enzymatic deacylation proceeds via a transient quinone methide like intermediate which facilitates the subsequent C–C/C−N coupled dimerization. Characterization of this unusual property of acyl fluostatins explains how dimerization takes place, and suggests a strategy for the assembly of C–C and C–N coupled aromatic polyketide dimers. Additionally, a deacylase FlsH was identified which may help to prevent accumulation of toxic quinone methides by catalyzing hydrolysis of the acyl group." @default.
- W2803457126 created "2018-06-01" @default.
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- W2803457126 date "2018-05-25" @default.
- W2803457126 modified "2023-10-13" @default.
- W2803457126 title "Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines" @default.
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- W2803457126 doi "https://doi.org/10.1038/s41467-018-04487-z" @default.
- W2803457126 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5970136" @default.
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