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- W2803472772 abstract "Background/aim: Infertility is a main health issue. The human Y chromosome contains essential genes for spermatogenesis, especially those located on four major intervals defined as AZFa, AZFb, AZFc, and AZFd. A partial deletion of the AZFc region is reported as a significant risk factor for oligo-/azoospermia. The main purpose of this study was to investigate the prevalence of partial deletions in the AZFc region (gr/gr, b1/b3, and b2/b3) in Iranian oligozoospermic candidates for intracytoplasmic sperm injection. Materials and methods: Multiplex PCR was used to assess the micro and partial deletions in 60 oligozoospermia infertile and 80 fertile men. Results: Two cases (3.33%) showed AZFb deletion but no microdeletion was detected in the control samples. In the AZFc region, 20% of the patients showed deletions, in which 15% and 5% showed gr/gr and b2/b3 deletions, respectively. However, 10% of the healthy individuals also showed partial deletions, including gr/gr (7.5%) and b2/b3 (2.5%). No significant correlation was detected between the presence of gr/gr microdeletion in patients and controls (P > 0.05). Conclusion: Our study showed that the partial AZFc deletions are not associated with male infertility in Iranian subjects." @default.
- W2803472772 created "2018-06-01" @default.
- W2803472772 date "2018-04-30" @default.
- W2803472772 modified "2023-09-26" @default.
- W2803472772 title "Analysis of Partial AZFc (gr/gr, b1/b3, and b2/b3) Deletions in Iranian Oligozoospermia Male Patients as The Candidates of Intra-Cytoplasmic Sperm Injection (ICSI)" @default.
- W2803472772 doi "https://doi.org/10.3906/sag-1710-71" @default.
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- W2803472772 hasPublicationYear "2018" @default.
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