Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803510059> ?p ?o ?g. }
- W2803510059 endingPage "e1007412" @default.
- W2803510059 startingPage "e1007412" @default.
- W2803510059 abstract "The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3' UTRs. Here we show that the nuclear m6A reader YTHDC1 is essential for embryo viability and germline development in mouse. Specifically, YTHDC1 is required for spermatogonial development in males and for oocyte growth and maturation in females; Ythdc1-deficient oocytes are blocked at the primary follicle stage. Strikingly, loss of YTHDC1 leads to extensive alternative polyadenylation in oocytes, altering 3' UTR length. Furthermore, YTHDC1 deficiency causes massive alternative splicing defects in oocytes. The majority of splicing defects in mutant oocytes are rescued by introducing wild-type, but not m6A-binding-deficient, YTHDC1. YTHDC1 is associated with the pre-mRNA 3' end processing factors CPSF6, SRSF3, and SRSF7. Thus, YTHDC1 plays a critical role in processing of pre-mRNA transcripts in the oocyte nucleus and may have similar non-redundant roles throughout fetal development." @default.
- W2803510059 created "2018-06-01" @default.
- W2803510059 creator A5002886426 @default.
- W2803510059 creator A5025185954 @default.
- W2803510059 creator A5027736631 @default.
- W2803510059 creator A5037447718 @default.
- W2803510059 creator A5060192955 @default.
- W2803510059 creator A5063285107 @default.
- W2803510059 creator A5072081531 @default.
- W2803510059 creator A5088549603 @default.
- W2803510059 date "2018-05-25" @default.
- W2803510059 modified "2023-10-16" @default.
- W2803510059 title "Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development" @default.
- W2803510059 cites W1764846306 @default.
- W2803510059 cites W1774964899 @default.
- W2803510059 cites W1895681508 @default.
- W2803510059 cites W1941339056 @default.
- W2803510059 cites W1970460195 @default.
- W2803510059 cites W1973159925 @default.
- W2803510059 cites W1974124243 @default.
- W2803510059 cites W1978570830 @default.
- W2803510059 cites W1981629946 @default.
- W2803510059 cites W1982675984 @default.
- W2803510059 cites W1982749428 @default.
- W2803510059 cites W1985267020 @default.
- W2803510059 cites W1986988560 @default.
- W2803510059 cites W1991230146 @default.
- W2803510059 cites W1991807334 @default.
- W2803510059 cites W1992739522 @default.
- W2803510059 cites W1995128009 @default.
- W2803510059 cites W2002458471 @default.
- W2803510059 cites W2007429249 @default.
- W2803510059 cites W2009308529 @default.
- W2803510059 cites W2011131953 @default.
- W2803510059 cites W2018831893 @default.
- W2803510059 cites W2022770379 @default.
- W2803510059 cites W2024117723 @default.
- W2803510059 cites W2025425793 @default.
- W2803510059 cites W2035905956 @default.
- W2803510059 cites W2039725641 @default.
- W2803510059 cites W2049409506 @default.
- W2803510059 cites W2050791777 @default.
- W2803510059 cites W2051037155 @default.
- W2803510059 cites W2061027592 @default.
- W2803510059 cites W2062821957 @default.
- W2803510059 cites W2063151549 @default.
- W2803510059 cites W2065847836 @default.
- W2803510059 cites W2071930821 @default.
- W2803510059 cites W2078826636 @default.
- W2803510059 cites W2078964320 @default.
- W2803510059 cites W2083248417 @default.
- W2803510059 cites W2091235283 @default.
- W2803510059 cites W2095528795 @default.
- W2803510059 cites W2098980484 @default.
- W2803510059 cites W2102872651 @default.
- W2803510059 cites W2105420135 @default.
- W2803510059 cites W2108234281 @default.
- W2803510059 cites W2118582028 @default.
- W2803510059 cites W2119429923 @default.
- W2803510059 cites W2124169297 @default.
- W2803510059 cites W2134124858 @default.
- W2803510059 cites W2134526812 @default.
- W2803510059 cites W2144403131 @default.
- W2803510059 cites W2153839236 @default.
- W2803510059 cites W2158217645 @default.
- W2803510059 cites W2158931804 @default.
- W2803510059 cites W2165547003 @default.
- W2803510059 cites W2175514210 @default.
- W2803510059 cites W2179438025 @default.
- W2803510059 cites W2180404227 @default.
- W2803510059 cites W2201760124 @default.
- W2803510059 cites W2210597779 @default.
- W2803510059 cites W2255131131 @default.
- W2803510059 cites W2255613730 @default.
- W2803510059 cites W2269054226 @default.
- W2803510059 cites W2269758801 @default.
- W2803510059 cites W2291938858 @default.
- W2803510059 cites W2509465044 @default.
- W2803510059 cites W2525507785 @default.
- W2803510059 cites W2534208693 @default.
- W2803510059 cites W2558981096 @default.
- W2803510059 cites W2559344646 @default.
- W2803510059 cites W2562211106 @default.
- W2803510059 cites W2586247640 @default.
- W2803510059 cites W2589225545 @default.
- W2803510059 cites W2591699245 @default.
- W2803510059 cites W2604767392 @default.
- W2803510059 cites W2620642044 @default.
- W2803510059 cites W2624979127 @default.
- W2803510059 cites W2632544498 @default.
- W2803510059 cites W2746255049 @default.
- W2803510059 cites W2749219966 @default.
- W2803510059 cites W2752985760 @default.
- W2803510059 cites W2753775066 @default.
- W2803510059 cites W2754391888 @default.
- W2803510059 cites W2762814002 @default.
- W2803510059 cites W2764301500 @default.
- W2803510059 cites W2765787092 @default.