Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803516105> ?p ?o ?g. }
- W2803516105 endingPage "3728" @default.
- W2803516105 startingPage "3719" @default.
- W2803516105 abstract "Abstract Cancer stem cells ( CSC s) are a small subset of heterogeneous cells existed in tumour tissues or cancer cell lines with self‐renewal and differentiation potentials. CSC s were considered to be responsible for the failure of conventional therapy and tumour recurrence. However, CSC s are not a static cell population, CSC s and non‐ CSC s are maintained in dynamic interconversion state by their self‐differentiation and dedifferentiation. Therefore, targeting CSC s for cancer therapy is still not enough,exploring the mechanism of dynamic interconversion between CSC s and non‐ CSC s and blocking the interconversion seems to be imperative. Exosomes are 30‐100 nm size in diameter extracellular vesicles ( EV s) secreted by multiple living cells into the extracellular space. They contain cell‐state‐specific bioactive materials, including DNA , mRNA , nc RNA , proteins, lipids, etc. with their specific surface markers, such as, CD 63, CD 81, Alix, Tsg101, etc. Exosomes have been considered as information carriers in cell communication between cancer cells and non‐cancer cells, which affect gene expressions and cellular signalling pathways of recipient cells by delivering their contents. Now that exosomes acted as information carriers, whether they played role in maintaining dynamic equilibrium state between CSC s and non‐ CSC s and their mechanism of activity are unknown. This review summarized the current research advance of exosomes’ role in maintaining CSC dynamic interconversion state and their possible mechanism of action, which will provide a better understanding the contribution of exosomes to dedifferentiation and stemness acquisition of non‐ CSC s, and highlight that exosomes might be taken as the attractive target approaches for cancer therapeutics." @default.
- W2803516105 created "2018-06-01" @default.
- W2803516105 creator A5012278873 @default.
- W2803516105 creator A5014027635 @default.
- W2803516105 creator A5014070201 @default.
- W2803516105 creator A5043252828 @default.
- W2803516105 date "2018-05-25" @default.
- W2803516105 modified "2023-10-05" @default.
- W2803516105 title "Emerging role of exosome signalling in maintaining cancer stem cell dynamic equilibrium" @default.
- W2803516105 cites W1507070939 @default.
- W2803516105 cites W1525870544 @default.
- W2803516105 cites W1736155067 @default.
- W2803516105 cites W1846631206 @default.
- W2803516105 cites W1879553156 @default.
- W2803516105 cites W1897820977 @default.
- W2803516105 cites W1899078684 @default.
- W2803516105 cites W1922364744 @default.
- W2803516105 cites W1969607893 @default.
- W2803516105 cites W1970413727 @default.
- W2803516105 cites W1971392922 @default.
- W2803516105 cites W1984618065 @default.
- W2803516105 cites W1985844219 @default.
- W2803516105 cites W1988214015 @default.
- W2803516105 cites W1991918456 @default.
- W2803516105 cites W1993140699 @default.
- W2803516105 cites W1999306007 @default.
- W2803516105 cites W2000799034 @default.
- W2803516105 cites W2003343932 @default.
- W2803516105 cites W2004878973 @default.
- W2803516105 cites W2005993715 @default.
- W2803516105 cites W2008627178 @default.
- W2803516105 cites W2009886857 @default.
- W2803516105 cites W2010107779 @default.
- W2803516105 cites W2015189241 @default.
- W2803516105 cites W2015256188 @default.
- W2803516105 cites W2023427658 @default.
- W2803516105 cites W2027230549 @default.
- W2803516105 cites W2033541023 @default.
- W2803516105 cites W2037535775 @default.
- W2803516105 cites W2038236600 @default.
- W2803516105 cites W2040140079 @default.
- W2803516105 cites W2051761998 @default.
- W2803516105 cites W2060133690 @default.
- W2803516105 cites W2061687333 @default.
- W2803516105 cites W2062984171 @default.
- W2803516105 cites W2066991609 @default.
- W2803516105 cites W2071123870 @default.
- W2803516105 cites W2071188263 @default.
- W2803516105 cites W2076798976 @default.
- W2803516105 cites W2086158594 @default.
- W2803516105 cites W2087688974 @default.
- W2803516105 cites W2089713288 @default.
- W2803516105 cites W2089946359 @default.
- W2803516105 cites W2094402715 @default.
- W2803516105 cites W2094727649 @default.
- W2803516105 cites W2098259366 @default.
- W2803516105 cites W2099676867 @default.
- W2803516105 cites W2104005622 @default.
- W2803516105 cites W2104926154 @default.
- W2803516105 cites W2109978756 @default.
- W2803516105 cites W2112519528 @default.
- W2803516105 cites W2114775469 @default.
- W2803516105 cites W2116178187 @default.
- W2803516105 cites W2119043140 @default.
- W2803516105 cites W2119764013 @default.
- W2803516105 cites W2129680066 @default.
- W2803516105 cites W2135943905 @default.
- W2803516105 cites W2138959855 @default.
- W2803516105 cites W2143729276 @default.
- W2803516105 cites W2148430424 @default.
- W2803516105 cites W2155441983 @default.
- W2803516105 cites W2159114297 @default.
- W2803516105 cites W2164762873 @default.
- W2803516105 cites W2166595775 @default.
- W2803516105 cites W2166846320 @default.
- W2803516105 cites W2169729679 @default.
- W2803516105 cites W2170883762 @default.
- W2803516105 cites W2176694530 @default.
- W2803516105 cites W2182766266 @default.
- W2803516105 cites W2190836196 @default.
- W2803516105 cites W2213440919 @default.
- W2803516105 cites W2297677101 @default.
- W2803516105 cites W2302712410 @default.
- W2803516105 cites W2323793261 @default.
- W2803516105 cites W2329768139 @default.
- W2803516105 cites W2330004628 @default.
- W2803516105 cites W2340119325 @default.
- W2803516105 cites W2343063345 @default.
- W2803516105 cites W2441633445 @default.
- W2803516105 cites W2464918474 @default.
- W2803516105 cites W2509039608 @default.
- W2803516105 cites W2559922077 @default.
- W2803516105 cites W2560161873 @default.
- W2803516105 cites W2574789425 @default.
- W2803516105 cites W2577912340 @default.
- W2803516105 cites W2586119928 @default.
- W2803516105 cites W2587972368 @default.
- W2803516105 cites W2590743929 @default.