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- W2803550898 abstract "Single-stranded DNA structures play a significant role in biological systems, in particular during replication, translation, and DNA repair. Tracts of simple repetitive DNA are associated with slipped-strand mispairing, which can lead to genetic diseases. Recent NMR studies of TTTA and CCTG repeats have shown that these sequences form mini-dumbbells (MDBs), leading to frameshift mutations. Here we explore the energy landscapes of (CCTG)2 and (TTTA)2, which are currently the smallest known molecules to form MDBs. While (CCTG)2 MDBs are stable, (TTTA)2 exhibits numerous other structures with lower energies. A key factor identified in the stabilization of MDB structures is the bonding strength between residues 1 and 4, and 5 and 8." @default.
- W2803550898 created "2018-06-01" @default.
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- W2803550898 date "2018-05-24" @default.
- W2803550898 modified "2023-09-26" @default.
- W2803550898 title "Energy Landscapes of Mini-Dumbbell DNA Octanucleotides" @default.
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- W2803550898 doi "https://doi.org/10.1021/acs.jctc.8b00262" @default.
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