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• W2803553304 abstract "Abstract The innate immunity is critically important in protection against virus infections, and in the case of RNA viral infections, the signaling mechanisms that initiate robust protective innate immunity without triggering autoimmune inflammation remain incompletely defined. In this study, we found the E3 ligase TRIM29 was specifically expressed in poly I:C–stimulated human myeloid dendritic cells. The induced TRIM29 played a negative role in type I IFN production in response to poly I:C or dsRNA virus reovirus infection. Importantly, the challenge of wild-type mice with reovirus led to lethal infection. In contrast, deletion of TRIM29 protected the mice from this developing lethality. Additionally, TRIM29−/− mice have lower titers of reovirus in the heart, intestine, spleen, liver, and brain because of elevated production of type I IFN. Mechanistically, TRIM29 was shown to interact with MAVS and subsequently induce its K11-linked ubiquitination and degradation. Taken together, TRIM29 regulates negatively the host innate immune response to RNA virus, which could be employed by RNA viruses for viral pathogenesis." @default.
• W2803553304 created "2018-06-01" @default.
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• W2803553304 date "2018-07-01" @default.
• W2803553304 modified "2023-10-02" @default.
• W2803553304 title "TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus" @default.
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• W2803553304 doi "https://doi.org/10.4049/jimmunol.1701569" @default.
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• W2803553304 hasPublicationYear "2018" @default.
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