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- W2803562912 abstract "Objective: To evaluate the utility of measures which have been used to assess bulbar function in ALS. Background: Historically, clinical trials in ALS have emphasized survival. When symptomatic benefit has been assessed, this has been determined by use of the revised ALS functional rating scale (ALSFRS-R) or quality of life (QOL) measures. Otherwise, bulbar function has not been emphasized of clinical trials. Design/Methods: Bulbar function was assessed in 120 ALS patients. A clinical observer made a diagnosis of impaired speech, swallowing, or salivation through direct observation of the subjects. Subjects completed the self-report Center for Neurologic Study-Bulbar Function Scale (CNS-BFS) and visual analog scales (VASs) for speech, swallowing and salivation. An evaluator scored the various items comprising the ALSFRS-R. Speech rate and time to swallow both liquids and solids were recorded. Correlations were made between clinician diagnosis and each of the evaluated measures. Results: The self-report CNS-BFS total score was highly correlated with the bulbar subscale of the ALSFRS-R (r= −0.90, p Conclusions: The CNS-BFS and the bulbar domain of the ALSFRS-R accurately predict impaired bulbar function in ALS patients, comparing favorably to clinician diagnosis. The recently developed CNS-BFS outperforms both the bulbar component of the ALSFRS-R and bulbar VASs when correlations are made between these scales and timed reading and swallowing. Based on these findings and its ease of administration, the CNS-BFS is a useful metric for assessing bulbar function in ALS patients in a research or clinical setting. Study Supported by: ALS Association Disclosure: Dr. Smith has nothing to disclose. Dr. Pioro has nothing to disclose. Dr. Pattee has nothing to disclose. Dr. Goslin has nothing to disclose. Dr. Meekins has nothing to disclose. Dr. Green has nothing to disclose. Dr. Macklin has received personal compensation for activities with Acorda Therapeutics, Lantheus Medical Imaging, and Shire Human Genetic Therapies. Dr. Macklin has received research support from Biotie Therapies, ALSA, ALSTDI, ALS Therapy Alliance, MJ Fox Foundation, A Coors Foundation, Autism Speaks, NIH, and HRSA." @default.
- W2803562912 created "2018-06-01" @default.
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- W2803562912 date "2017-04-18" @default.
- W2803562912 modified "2023-09-26" @default.
- W2803562912 title "Assessment of Bulbar Function in ALS (P3.134)" @default.
- W2803562912 hasPublicationYear "2017" @default.
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