FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803572561> ?p ?o ?g. }

• W2803572561 endingPage "212" @default.
• W2803572561 startingPage "205" @default.
• W2803572561 abstract "Structural studies related to Middle East Respiratory Syndrome Coronavirus (MERS CoV) infection process are so limited. In this study, molecular dynamics (MD) simulations were carried out to unravel changes in the MERS CoV heptad repeat domains (HRs) and factors affecting fusion state HR stability. Results indicated that HR trimer is more rapidly stabilized, having stable system energy and lower root mean square deviations (RMSDs). While trimers were the predominant active form of CoVs HRs, monomers were also discovered in both of viral and cellular membranes. In order to find the differences between S2 monomer and trimer molecular dynamics, S2 monomer was modelled and subjected to MD simulation. In contrast to S2 trimer, S2 monomer was unstable, having high RMSDs with major drifts above 8 Å. Fluctuation of HR residue positions revealed major changes in the C-terminal of HR2 and the linker coil between HR1 and HR2 in both monomer and trimer. Hydrophobic residues at the a and d positions of HR helices stabilize the whole system, with minimal changes in RMSD. The global distance test and contact area difference scores support instability of MERS CoV S2 monomer. Analysis of HR1-HR2 inter-residue contacts and interaction energy revealed three energy scales along HR helices. Two strong interaction energies were identified at the start of the HR2 helix and at the C-terminal of HR2. The identified critical residues by MD simulation and residues at the a and d positions of HR helix were strong stabilizers of HR recognition." @default.
• W2803572561 created "2018-06-01" @default.
• W2803572561 creator A5001126459 @default.
• W2803572561 creator A5008872173 @default.
• W2803572561 creator A5043847017 @default.
• W2803572561 creator A5048639910 @default.
• W2803572561 creator A5077595521 @default.
• W2803572561 date "2018-08-01" @default.
• W2803572561 modified "2023-10-17" @default.
• W2803572561 title "Molecular dynamics of Middle East Respiratory Syndrome Coronavirus (MERS CoV) fusion heptad repeat trimers" @default.
• W2803572561 cites W1482971402 @default.
• W2803572561 cites W1505815416 @default.
• W2803572561 cites W1993374993 @default.
• W2803572561 cites W2013090907 @default.
• W2803572561 cites W2016292399 @default.
• W2803572561 cites W2017847190 @default.
• W2803572561 cites W2022810422 @default.
• W2803572561 cites W2027408247 @default.
• W2803572561 cites W2027887784 @default.
• W2803572561 cites W2050000134 @default.
• W2803572561 cites W2052312932 @default.
• W2803572561 cites W2052583752 @default.
• W2803572561 cites W2068999747 @default.
• W2803572561 cites W2086731797 @default.
• W2803572561 cites W2092685402 @default.
• W2803572561 cites W2097188280 @default.
• W2803572561 cites W2098055048 @default.
• W2803572561 cites W2098870916 @default.
• W2803572561 cites W2103815459 @default.
• W2803572561 cites W2106140689 @default.
• W2803572561 cites W2106967530 @default.
• W2803572561 cites W2111005311 @default.
• W2803572561 cites W2112147913 @default.
• W2803572561 cites W2113267464 @default.
• W2803572561 cites W2153074293 @default.
• W2803572561 cites W2158707944 @default.
• W2803572561 cites W2166133396 @default.
• W2803572561 cites W2166867592 @default.
• W2803572561 cites W2170024189 @default.
• W2803572561 cites W2284517327 @default.
• W2803572561 cites W2292700442 @default.
• W2803572561 cites W2332276476 @default.
• W2803572561 cites W2332532573 @default.
• W2803572561 cites W2395574273 @default.
• W2803572561 cites W2538979123 @default.
• W2803572561 cites W2592477520 @default.
• W2803572561 cites W2606148195 @default.
• W2803572561 cites W2606636069 @default.
• W2803572561 cites W2612594162 @default.
• W2803572561 cites W2739532038 @default.
• W2803572561 cites W2766605105 @default.
• W2803572561 cites W2782680193 @default.
• W2803572561 doi "https://doi.org/10.1016/j.compbiolchem.2018.05.020" @default.
• W2803572561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7106505" @default.
• W2803572561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29803965" @default.
• W2803572561 hasPublicationYear "2018" @default.
• W2803572561 type Work @default.
• W2803572561 sameAs 2803572561 @default.
• W2803572561 citedByCount "14" @default.
• W2803572561 countsByYear W28035725612020 @default.
• W2803572561 countsByYear W28035725612021 @default.
• W2803572561 countsByYear W28035725612022 @default.
• W2803572561 countsByYear W28035725612023 @default.
• W2803572561 crossrefType "journal-article" @default.
• W2803572561 hasAuthorship W2803572561A5001126459 @default.
• W2803572561 hasAuthorship W2803572561A5008872173 @default.
• W2803572561 hasAuthorship W2803572561A5043847017 @default.
• W2803572561 hasAuthorship W2803572561A5048639910 @default.
• W2803572561 hasAuthorship W2803572561A5077595521 @default.
• W2803572561 hasBestOaLocation W28035725611 @default.
• W2803572561 hasConcept C104317684 @default.
• W2803572561 hasConcept C122146531 @default.
• W2803572561 hasConcept C12554922 @default.
• W2803572561 hasConcept C142724271 @default.
• W2803572561 hasConcept C147597530 @default.
• W2803572561 hasConcept C166940927 @default.
• W2803572561 hasConcept C167625842 @default.
• W2803572561 hasConcept C178790620 @default.
• W2803572561 hasConcept C185592680 @default.
• W2803572561 hasConcept C18903297 @default.
• W2803572561 hasConcept C2776403692 @default.
• W2803572561 hasConcept C2777691041 @default.
• W2803572561 hasConcept C2778530040 @default.
• W2803572561 hasConcept C2779134260 @default.
• W2803572561 hasConcept C2779546866 @default.
• W2803572561 hasConcept C2779965526 @default.
• W2803572561 hasConcept C3008058167 @default.
• W2803572561 hasConcept C47701112 @default.
• W2803572561 hasConcept C521977710 @default.
• W2803572561 hasConcept C524204448 @default.
• W2803572561 hasConcept C55493867 @default.
• W2803572561 hasConcept C55988834 @default.
• W2803572561 hasConcept C59593255 @default.
• W2803572561 hasConcept C71924100 @default.
• W2803572561 hasConcept C8010536 @default.
• W2803572561 hasConcept C86803240 @default.
• W2803572561 hasConceptScore W2803572561C104317684 @default.
• W2803572561 hasConceptScore W2803572561C122146531 @default.

• next