FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803578905> ?p ?o ?g. }

• W2803578905 endingPage "58" @default.
• W2803578905 startingPage "49" @default.
• W2803578905 abstract "Age-related neurodegenerative diseases are of critical concern to the general population and research/medical community due to their health impact and socioeconomic consequences. A feature of most, if not all, neurodegenerative disorders is the presence of proteinopathies, in which misfolded or conformationally altered proteins drive disease progression and are often used as a primary neuropathological marker of disease. In particular, Alzheimer’s disease (AD) is characterized by abnormal accumulation of protein aggregates, primarily extracellular plaques composed of the Aβ peptide and intracellular tangles comprised of the tau protein, both of which may indicate a primary defect in protein clearance. Protein degradation is a key cellular mechanism for protein homeostasis and is essential for cell survival but is disrupted in neurodegenerative diseases. Dysregulation in proteolytic pathways – mainly the autophagic-lysosomal system (A-LS) and the ubiquitin-proteasome system (UPS) – has been increasingly associated with proteinopathies in neurodegenerative diseases. Here we review the role of dysfunctional autophagy underlying AD-related proteinopathy and discuss how to model this aspect of disease, as well as summarize recent advances in translational strategies for targeted A-LS dysfunction in AD." @default.
• W2803578905 created "2018-06-01" @default.
• W2803578905 creator A5010802378 @default.
• W2803578905 creator A5024780477 @default.
• W2803578905 creator A5037691077 @default.
• W2803578905 creator A5079535159 @default.
• W2803578905 date "2019-04-01" @default.
• W2803578905 modified "2023-10-01" @default.
• W2803578905 title "Alzheimer’s disease and the autophagic-lysosomal system" @default.
• W2803578905 cites W1408841334 @default.
• W2803578905 cites W1494109356 @default.
• W2803578905 cites W1516940938 @default.
• W2803578905 cites W1527671059 @default.
• W2803578905 cites W1600934558 @default.
• W2803578905 cites W1602771322 @default.
• W2803578905 cites W1784307531 @default.
• W2803578905 cites W1803199265 @default.
• W2803578905 cites W1811346881 @default.
• W2803578905 cites W1839303532 @default.
• W2803578905 cites W1884727057 @default.
• W2803578905 cites W1919353 @default.
• W2803578905 cites W1965050626 @default.
• W2803578905 cites W1966629753 @default.
• W2803578905 cites W1967519462 @default.
• W2803578905 cites W1968322176 @default.
• W2803578905 cites W1971616282 @default.
• W2803578905 cites W1972336737 @default.
• W2803578905 cites W1972522869 @default.
• W2803578905 cites W1975806945 @default.
• W2803578905 cites W1979869432 @default.
• W2803578905 cites W1980520006 @default.
• W2803578905 cites W1981964613 @default.
• W2803578905 cites W1982959887 @default.
• W2803578905 cites W1984544042 @default.
• W2803578905 cites W1987155530 @default.
• W2803578905 cites W1987208492 @default.
• W2803578905 cites W1987489496 @default.
• W2803578905 cites W1988117342 @default.
• W2803578905 cites W1990713427 @default.
• W2803578905 cites W1992532731 @default.
• W2803578905 cites W1993201929 @default.
• W2803578905 cites W1993672496 @default.
• W2803578905 cites W1995042437 @default.
• W2803578905 cites W1997816650 @default.
• W2803578905 cites W1999522052 @default.
• W2803578905 cites W2000158949 @default.
• W2803578905 cites W2002093269 @default.
• W2803578905 cites W2003618511 @default.
• W2803578905 cites W2005678965 @default.
• W2803578905 cites W2007505836 @default.
• W2803578905 cites W2008744347 @default.
• W2803578905 cites W2010846728 @default.
• W2803578905 cites W2011134915 @default.
• W2803578905 cites W2013313629 @default.
• W2803578905 cites W2015020748 @default.
• W2803578905 cites W2017363986 @default.
• W2803578905 cites W2017861337 @default.
• W2803578905 cites W2018342879 @default.
• W2803578905 cites W2020131301 @default.
• W2803578905 cites W2027177575 @default.
• W2803578905 cites W2027619670 @default.
• W2803578905 cites W2027649342 @default.
• W2803578905 cites W2029563076 @default.
• W2803578905 cites W2032419750 @default.
• W2803578905 cites W2032421019 @default.
• W2803578905 cites W2034888251 @default.
• W2803578905 cites W2036878135 @default.
• W2803578905 cites W2037653131 @default.
• W2803578905 cites W2038803241 @default.
• W2803578905 cites W2040912634 @default.
• W2803578905 cites W2046234674 @default.
• W2803578905 cites W2048125278 @default.
• W2803578905 cites W2048210493 @default.
• W2803578905 cites W2049599293 @default.
• W2803578905 cites W2050135092 @default.
• W2803578905 cites W2051035876 @default.
• W2803578905 cites W2055147828 @default.
• W2803578905 cites W2057915818 @default.
• W2803578905 cites W2058880763 @default.
• W2803578905 cites W2064746187 @default.
• W2803578905 cites W2066155243 @default.
• W2803578905 cites W2068288454 @default.
• W2803578905 cites W2070752626 @default.
• W2803578905 cites W2070835061 @default.
• W2803578905 cites W2078941062 @default.
• W2803578905 cites W2079378641 @default.
• W2803578905 cites W2081014274 @default.
• W2803578905 cites W2082229119 @default.
• W2803578905 cites W2086477221 @default.
• W2803578905 cites W2086540565 @default.
• W2803578905 cites W2088698513 @default.
• W2803578905 cites W2089761608 @default.
• W2803578905 cites W2090455820 @default.
• W2803578905 cites W2090739159 @default.
• W2803578905 cites W2091599508 @default.
• W2803578905 cites W2092646825 @default.
• W2803578905 cites W2096223549 @default.
• W2803578905 cites W2096649028 @default.

• next