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W2803580518 abstract "We observed that astrocytes, fibroblastoid cells andmicroglia can be enriched from mixed glial cultures. Astrocytes and fibroblastoid cellsexpress Cx43 gap junction protein. These cells upon infection show syncytium formation.The Lucifer dye transfer experiment makes it evident that the gap junction channels arealtered in infected cells. As a result of this the dye transfer is hindered in the syncytiumforming regions. This same observation was seen in case of infected astrocytes. Thus we canconclude that MHV infection brings upon similar effect on fibroblastoid cells like astrocytes.Further investigation at mRNA and protein levels by Quantitative-PCR is required tocomment on regulation at transcriptional or translational level. Confirmation of fibroblastoidtype of cells further by using CD-34 antibody is also required.N9 microglial cell lines have shown a down regulation of Cx43 in MHV infected cellscompared to uninfected ones. Literature reveals an up-regulation of Cx43 in primarymicroglia under wound stab conditions. Whether Cx43 is expressed by N9 is still a topic ofresearch. Effect of MHV infection upon N9 is also not well documented. Thus, from theexperiments we performed, it can be said that Cx43 is expressed in N9 cells. Furtherinvestigation of Cx43 regulation at mRNA levels and gap junction channel formation is yet tobe done.In conclusion, it can be revealed that both astrocytes and fibroblastoids express Cx43.As theyboth express Cx43 they may be physiologically connected through gap junction inmaintaining the homeostasis in CNS and BBB (Blood Brain Barrier). N9 also express Cx43at protein level and altered due to MHV infection which can signify that expression of Cx43may have a role in MHV infection." @default.
W2803580518 created "2018-06-01" @default.
W2803580518 creator A5062277910 @default.
W2803580518 date "2014-01-01" @default.
W2803580518 modified "2023-09-27" @default.
W2803580518 title "Effect of Mouse Hepatitis Virus (MHV) infection in alteration of Connexin 43 in Astrocytes, Meningeal fibroblastoid and Microglia" @default.
W2803580518 hasPublicationYear "2014" @default.
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