FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803612204> ?p ?o ?g. }

• W2803612204 abstract "Early cancer diagnosis is one of the most important challenges of cancer research, since in many cancers it can lead to cure for patients with early stage diseases. For epithelial ovarian cancer (which is the leading cause of death among gynaecologic malignancies) the classical detection approach is based on measurements of CA-125 biomarker. However, the poor sensitivity and specificity of this biomarker impacts the detection of early-stage cancers. Here we use a computational approach to investigate the effect of combining multiple biomarkers for ovarian cancer (e.g., CA-125 and IL-7), to improve early cancer detection. We show that this combined biomarkers approach could lead indeed to earlier cancer detection. However, the immune response (which influences the level of secreted IL-7 biomarker) plays an important role in improving and/or delaying cancer detection. Moreover, the detection level of IL-7 immune biomarker could be in a range that would not allow to distinguish between a healthy state and a cancerous state. In this case, the construction of solution diagrams in the space generated by the IL-7 and CA-125 biomarkers could allow us predict the long-term evolution of cancer biomarkers, thus allowing us to make predictions on cancer detection times. Combining cancer and immune biomarkers could improve cancer detection times, and any predictions that could be made (at least through the use of CA-125/IL-7 biomarkers) are patient specific." @default.
• W2803612204 created "2018-06-01" @default.
• W2803612204 creator A5006689072 @default.
• W2803612204 creator A5022841113 @default.
• W2803612204 date "2018-03-20" @default.
• W2803612204 modified "2023-09-30" @default.
• W2803612204 title "Improving cancer detection through combinations of cancer and immune biomarkers: a modelling approach" @default.
• W2803612204 cites W1507160172 @default.
• W2803612204 cites W1544307647 @default.
• W2803612204 cites W1595607998 @default.
• W2803612204 cites W1761790947 @default.
• W2803612204 cites W1821140461 @default.
• W2803612204 cites W1965069792 @default.
• W2803612204 cites W1969111307 @default.
• W2803612204 cites W1970080794 @default.
• W2803612204 cites W1976876000 @default.
• W2803612204 cites W1979253118 @default.
• W2803612204 cites W1984507431 @default.
• W2803612204 cites W1988880705 @default.
• W2803612204 cites W1997632704 @default.
• W2803612204 cites W2017455926 @default.
• W2803612204 cites W2019090872 @default.
• W2803612204 cites W2025498302 @default.
• W2803612204 cites W2031384603 @default.
• W2803612204 cites W2048752013 @default.
• W2803612204 cites W2049113945 @default.
• W2803612204 cites W2052116378 @default.
• W2803612204 cites W2052328580 @default.
• W2803612204 cites W2056731892 @default.
• W2803612204 cites W2065117328 @default.
• W2803612204 cites W2072120276 @default.
• W2803612204 cites W2072347219 @default.
• W2803612204 cites W2087137877 @default.
• W2803612204 cites W2094550799 @default.
• W2803612204 cites W2102306754 @default.
• W2803612204 cites W2106353254 @default.
• W2803612204 cites W2114474071 @default.
• W2803612204 cites W2117529508 @default.
• W2803612204 cites W2117845602 @default.
• W2803612204 cites W2121686307 @default.
• W2803612204 cites W2123456079 @default.
• W2803612204 cites W2129239355 @default.
• W2803612204 cites W2133586877 @default.
• W2803612204 cites W2135866806 @default.
• W2803612204 cites W2135932885 @default.
• W2803612204 cites W2142059159 @default.
• W2803612204 cites W2144024213 @default.
• W2803612204 cites W2145711849 @default.
• W2803612204 cites W2149034648 @default.
• W2803612204 cites W2155464942 @default.
• W2803612204 cites W2161098560 @default.
• W2803612204 cites W2162290846 @default.
• W2803612204 cites W2164890175 @default.
• W2803612204 cites W2167006237 @default.
• W2803612204 cites W2171283491 @default.
• W2803612204 cites W2250013023 @default.
• W2803612204 cites W2339025832 @default.
• W2803612204 cites W2481718545 @default.
• W2803612204 cites W2527772066 @default.
• W2803612204 cites W2557243447 @default.
• W2803612204 cites W2591773109 @default.
• W2803612204 cites W2604627240 @default.
• W2803612204 cites W2606379057 @default.
• W2803612204 cites W2612327959 @default.
• W2803612204 cites W4232699937 @default.
• W2803612204 doi "https://doi.org/10.1186/s12967-018-1432-8" @default.
• W2803612204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5859525" @default.
• W2803612204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29554938" @default.
• W2803612204 hasPublicationYear "2018" @default.
• W2803612204 type Work @default.
• W2803612204 sameAs 2803612204 @default.
• W2803612204 citedByCount "17" @default.
• W2803612204 countsByYear W28036122042019 @default.
• W2803612204 countsByYear W28036122042020 @default.
• W2803612204 countsByYear W28036122042021 @default.
• W2803612204 countsByYear W28036122042022 @default.
• W2803612204 countsByYear W28036122042023 @default.
• W2803612204 crossrefType "journal-article" @default.
• W2803612204 hasAuthorship W2803612204A5006689072 @default.
• W2803612204 hasAuthorship W2803612204A5022841113 @default.
• W2803612204 hasBestOaLocation W28036122041 @default.
• W2803612204 hasConcept C104317684 @default.
• W2803612204 hasConcept C121608353 @default.
• W2803612204 hasConcept C124535831 @default.
• W2803612204 hasConcept C126322002 @default.
• W2803612204 hasConcept C143998085 @default.
• W2803612204 hasConcept C146357865 @default.
• W2803612204 hasConcept C151730666 @default.
• W2803612204 hasConcept C203014093 @default.
• W2803612204 hasConcept C2777002142 @default.
• W2803612204 hasConcept C2780427987 @default.
• W2803612204 hasConcept C2781197716 @default.
• W2803612204 hasConcept C2985322473 @default.
• W2803612204 hasConcept C46111723 @default.
• W2803612204 hasConcept C55493867 @default.
• W2803612204 hasConcept C71924100 @default.
• W2803612204 hasConcept C86803240 @default.
• W2803612204 hasConcept C8891405 @default.
• W2803612204 hasConceptScore W2803612204C104317684 @default.
• W2803612204 hasConceptScore W2803612204C121608353 @default.

• next