Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803619772> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2803619772 endingPage "2876" @default.
- W2803619772 startingPage "2872" @default.
- W2803619772 abstract "Abstract On a roundtrip to Mars, astronauts are expectedly exposed to an approximate amount of radiation that exceeds the lifetime limits on Earth. This elevated radiation dose is mainly due to Galactic Cosmic Rays and Solar Particle Events. Specific patterns of the N ‐glycosylation of human Igs have already been associated with various ailments such as autoimmune diseases, malignant transformation, chronic inflammation, and ageing. The focus of our work was to investigate the effect of low‐energy proton irradiation on the IgG N ‐glycosylation profile with the goal if disease associated changes could be detected during space travel and not altered by space radiation. Two ionization sources were used during the experiments, a Van de Graaff generator for the irradiation of solidified hIgG samples in vacuum, and a Tandetron accelerator to irradiate hIgG samples in aqueous solution form. Structural carbohydrate analysis was accomplished by CE with laser induced fluorescent detection to determine the effects of simulated space radiation on N ‐glycosylation of hIgG1 samples. Our results revealed that even several thousand times higher radiation doses that of astronauts can suffer during long duration missions beyond the shielding environment of Low Earth Orbit, no changes were observed in hIgG1 N ‐glycosylation. Consequently, changes in N ‐linked carbohydrate profile of IgG1 can be used as molecular diagnostic tools in space." @default.
- W2803619772 created "2018-06-01" @default.
- W2803619772 creator A5030330852 @default.
- W2803619772 creator A5052551196 @default.
- W2803619772 creator A5057698527 @default.
- W2803619772 creator A5066055845 @default.
- W2803619772 creator A5068813928 @default.
- W2803619772 creator A5028617007 @default.
- W2803619772 date "2018-06-14" @default.
- W2803619772 modified "2023-10-14" @default.
- W2803619772 title "The effect of simulated space radiation on the <b> <i>N</i> </b> ‐glycosylation of human immunoglobulin G1" @default.
- W2803619772 cites W1979720809 @default.
- W2803619772 cites W1982381330 @default.
- W2803619772 cites W1985283713 @default.
- W2803619772 cites W2004128344 @default.
- W2803619772 cites W2041736166 @default.
- W2803619772 cites W2065225814 @default.
- W2803619772 cites W2089708720 @default.
- W2803619772 cites W2104342488 @default.
- W2803619772 cites W2147306168 @default.
- W2803619772 cites W2150738279 @default.
- W2803619772 cites W221074985 @default.
- W2803619772 cites W2396533964 @default.
- W2803619772 cites W2408765418 @default.
- W2803619772 cites W2523589472 @default.
- W2803619772 cites W2529882214 @default.
- W2803619772 cites W2581531650 @default.
- W2803619772 cites W2583594052 @default.
- W2803619772 cites W2609844681 @default.
- W2803619772 cites W2793325624 @default.
- W2803619772 cites W40173189 @default.
- W2803619772 doi "https://doi.org/10.1002/elps.201800151" @default.
- W2803619772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29775210" @default.
- W2803619772 hasPublicationYear "2018" @default.
- W2803619772 type Work @default.
- W2803619772 sameAs 2803619772 @default.
- W2803619772 citedByCount "4" @default.
- W2803619772 countsByYear W28036197722019 @default.
- W2803619772 countsByYear W28036197722021 @default.
- W2803619772 countsByYear W28036197722023 @default.
- W2803619772 crossrefType "journal-article" @default.
- W2803619772 hasAuthorship W2803619772A5028617007 @default.
- W2803619772 hasAuthorship W2803619772A5030330852 @default.
- W2803619772 hasAuthorship W2803619772A5052551196 @default.
- W2803619772 hasAuthorship W2803619772A5057698527 @default.
- W2803619772 hasAuthorship W2803619772A5066055845 @default.
- W2803619772 hasAuthorship W2803619772A5068813928 @default.
- W2803619772 hasConcept C111337013 @default.
- W2803619772 hasConcept C120665830 @default.
- W2803619772 hasConcept C121332964 @default.
- W2803619772 hasConcept C12554922 @default.
- W2803619772 hasConcept C153385146 @default.
- W2803619772 hasConcept C185544564 @default.
- W2803619772 hasConcept C185592680 @default.
- W2803619772 hasConcept C192562407 @default.
- W2803619772 hasConcept C2777313579 @default.
- W2803619772 hasConcept C54516573 @default.
- W2803619772 hasConcept C55493867 @default.
- W2803619772 hasConcept C86611320 @default.
- W2803619772 hasConcept C86803240 @default.
- W2803619772 hasConceptScore W2803619772C111337013 @default.
- W2803619772 hasConceptScore W2803619772C120665830 @default.
- W2803619772 hasConceptScore W2803619772C121332964 @default.
- W2803619772 hasConceptScore W2803619772C12554922 @default.
- W2803619772 hasConceptScore W2803619772C153385146 @default.
- W2803619772 hasConceptScore W2803619772C185544564 @default.
- W2803619772 hasConceptScore W2803619772C185592680 @default.
- W2803619772 hasConceptScore W2803619772C192562407 @default.
- W2803619772 hasConceptScore W2803619772C2777313579 @default.
- W2803619772 hasConceptScore W2803619772C54516573 @default.
- W2803619772 hasConceptScore W2803619772C55493867 @default.
- W2803619772 hasConceptScore W2803619772C86611320 @default.
- W2803619772 hasConceptScore W2803619772C86803240 @default.
- W2803619772 hasFunder F4320326762 @default.
- W2803619772 hasIssue "22" @default.
- W2803619772 hasLocation W28036197721 @default.
- W2803619772 hasLocation W28036197722 @default.
- W2803619772 hasOpenAccess W2803619772 @default.
- W2803619772 hasPrimaryLocation W28036197721 @default.
- W2803619772 hasRelatedWork W1985871717 @default.
- W2803619772 hasRelatedWork W2003243363 @default.
- W2803619772 hasRelatedWork W2034034393 @default.
- W2803619772 hasRelatedWork W2047284239 @default.
- W2803619772 hasRelatedWork W2083663337 @default.
- W2803619772 hasRelatedWork W2102050418 @default.
- W2803619772 hasRelatedWork W2899084033 @default.
- W2803619772 hasRelatedWork W2952106524 @default.
- W2803619772 hasRelatedWork W4328046093 @default.
- W2803619772 hasRelatedWork W2092574026 @default.
- W2803619772 hasVolume "39" @default.
- W2803619772 isParatext "false" @default.
- W2803619772 isRetracted "false" @default.
- W2803619772 magId "2803619772" @default.
- W2803619772 workType "article" @default.