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- W2803627583 abstract "Objective : In this study, based on children's medication preferences, Synsepalum dulcificum and Siraitia grosvenorii as raw material were used to develop a flavoring medicine for children. Methods : Synsepalum dulcificum and Siraitia grosvenorii as the raw material were applied to extract the Synsepalum dulcificum powder and Siraitia grosvenorii powder respectively, according to the orthogonal test design; the optimal proportion of flavoring powder was obtained. Low-substituted hydroxypropyl cellulose(L-HPC), polyvinylpolypyrrolidone(PVPP), sodium carboxymethyl starch(CMS-Na), microcrystalline cellulose(MCC) were taken, according to the orthogonal test design the optimum proportion of auxiliary materials, then the flavoring tablets was prepared according to the preparation process. Results : Through orthogonal test design, the optimum ratio of Synsepalum dulcificum: Siraitia grosvenorii was 1:3, and mixing them up in proportion; the optimum ratio of L-HPC: PVPP: CMS-Na: MCC was 10: 8: 3: 6, and mix them up in proportion. Equal amounts of sugar and salt were obtained by mass ratio of 1 to 1. Mixing 1/3 amount of flavoring powder with 3/4 amount of auxiliary materials, using 20% ethanol as a wetting agent, using the remaining sugar as a filler, and granulating. After the granules were dried and whole grain, add the remaining auxiliary materials and magnesium stearate were added, then the flavoring tablets were prepared. Conclusion : The effects of this formula were prominent, which could effectively intervene the taste of children's medicine; solve the practical problems concerning taking medications in children. Keywords : Synsepalum dulcificum; Siraitia grosvenorii; drug use in children; flavoring tablets" @default.
- W2803627583 created "2018-06-01" @default.
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- W2803627583 date "2018-05-15" @default.
- W2803627583 modified "2023-09-22" @default.
- W2803627583 title "DEVELOPMENT OF A KIND OF FLAVORING TABLETS FOR CHILDREN'S USE" @default.
- W2803627583 doi "https://doi.org/10.22270/jddt.v8i3.1755" @default.
- W2803627583 hasPublicationYear "2018" @default.
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